In a study reported in the journal The Prostate researchers found that a high fat diet resulted in activation of NF-kB in the abdominal cavity, thymus, spleen, and prostate in mice studies and concluded “Our studies provide evidence that a high-fat diet increases the activation of NF-kB along with elevated levels of NADPH oxidase components which might lead to intraprostatic inflammation” and this strengthens the link between a high-fat diet and possible prostatic disease including BPH and prostate cancer. In the study non-obese
NF-kB reporter mice were provided a high fat diet for 4, 8 and 12 weeks and a second group were fed a regular diet. The high fat diet group had a significant increase in prostate weight, and prostate expression of markers of oxidative stress and increased inflammation. This provided evidence that a high fat diet causes proliferation, inflammation, and oxidative stress that can lead to benign prostatic hypertrophy (BPH), prostatitis, and cancer of the prostate.