Posts Tagged ‘BPA’

BPA/Inflammatory Breast Cancer Connection.

Wednesday, April 12th, 2017

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The chemical bisphenol A (BPA) seems to aid the survival of inflammatory breast cancer cells that reveals a possible mechanism for how the disease grows according to new research in the journal Carcinogenesis. They found that BPA increases the cell signaling pathways known as mitogen-activated protein kinases (MAPK) in inflammatory breast cancer cells. Researchers said “the study is the first to show that BPA increases signaling thorough receptors that communicate with the MAPK pathway and that the presence of BPA may lead to resistance to cancer drugs targetinmg this pathweay. In our cell model, more signaling led to increased growth of the cancer cells”

Researchers started by treating Inflammatory Breast Cancer cells with six endocrine-disrupting chemicals commonly found in the everyday environment found in food, medicine and agricultural products. The found that BPA, in addition to chemicals trichloroethane (HPTE) and methoxychlor, caused an increase in signaling to epidermal growth factor receptors (EGFR), that lie on the cell surface. When cells were treated with low doses of BPA, there was nearly a doubling of EGER and signaling to the MAPK pathway also increased. This weas accompanied with a rise in indicators of cancer cell growth. They also found that BPA exposure inhibited the effectiveness of drugs that work to kill cancer cells by inhibiting EGFR signaling.  Research is ongoing.

Can Chemical Exposure Affect Your Vitamin D Level?

Friday, September 23rd, 2016

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Recent research published in the Journal of Clinical Endocrinology and Metabolism concluded that exposure to bisphenol A (BPA) and other endocrine-disrupting chemicals (EDC’s) may reduce levels of vitamin D in the bloodstream. EDC’s are chemicals that interfere with hormones in the body and can have adverse health effects.

The review included over 1,300 studies that found links between chemical exposure and health problems including infertility, obesity, diabetes, neurological problems and hormone-related cancers. In the study 4.667 adults previously in a national survey between 2005 and 2010 in which participants provided blood samples so their vitamin D level could be measured, and urine samples to evaluate EDC exposure or specifically substances left behind after the body metabolized BPA and phthalates. Results showed that people exposed to larger amounts of phthalates were more likely to have low levels of vitamin D in the bloodstream that subjects who were exposed to smaller amounts of EDC’s and this was stronger in women., The researchers also found an association between exposure to higher levels of BPA and reduced vitamin D levels in women but the relationship was not statistically significant in men. Researchers acknowledged that more research was needed. EDC’s are found in everyday products and throughout the environment and vitamin D levels have been implicated in outcomes of numerous conditions such as cardiovascular disease, diabetes, and cancer.

BPS plastic more harmful than BPA plastic.

Wednesday, August 17th, 2016

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Recent research reported on CNN news from UCLA concluded BPS that replaced BPA  because of concerns about its harmful effect on the reproductive system in women and may be more harmful than BPA.  BPS replaced the discontinued BPA in plastic bottles and other products and now is found to damage a woman’s eggs at a lower dose that BPA.

Consumer demands have led companies to replace BPA with other related compounds found in many “BPA-free” products. However, the safety of these new products were unknown and that led to this new study. Researchers asked specifically whether BPS could impart detrimental effects on reproduction similar to BPA. A common lab model, the round worm, was exposed to several concentrations of BPA and/or BPS  that approximate the levels of BPA and/or BPS found in humans,. The then followed the worms through the duration of their reproductuve periods and measured their fertility.

Findings showed that compared with controls, worms exposed to either BPA or BPS, or combinations of the two, had decreased fertility. They were surprised to find that these effects were seen at lower doses of BPS than of BPA suggesting that BPS may be more damaging to the reproductive system. The study is of concern because the same reproductive processes that are disruptive in roundworms are found in mammals and BPS is currently found in many consumer products. Researchers concluded that “There is a great need for the coordinated safety assessment of multiple substitutes and mixtures of chemicals before their use in product replacement. But the good news is that a number of governmental programs and academic labs are now moving in that direction.”

Is BPA Linked to Breast Cancer Tumor Growth?

Friday, March 14th, 2014

logo1267406_mdA new study published online in the Journal of Steroid Biochemistry and Molecular Biology concluded that their research results could not say that bisphenol-A (BPA) causes breast cancer but it could contribute to its growth because it disrupts the genes that defend against that growth., BPA is a synthetic compound that has been widely used in plastics, such as food storage containers, the lining of canned food containers, and until recently baby bottles.

Researchers found that when breast cancer and mammary gland cells were exposed to BPA in lab tests, the BPA worked together with naturally present molecules such as estrogen to create abnormal amounts of HOTAIR expression. HOTAIR is a part of long, non-coding RNA,that does not produce a protein on its own but, when it is being expressed or functioning, it can suppress genes that would normally slow tumor growth or cause cancer cells to die and has been linked to breast tumors, and others. Researchers said “We weresuprised to find that BPA not only increased HOTAIR in tumor cells but also in normal breast tissue.”