Posts Tagged ‘DNA’

Can Gene Inactivation Prevent Aging and Cancer?

Wednesday, March 8th, 2017

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A new study published in the journal Nature concluded that every body cell contains the complete DNA library and the so called methyl groups regulate the DNA library in tissues so that only the genetic information needed in that tissue is expressed. Now for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, subsequently may lead to the emergence of cancer.

Each body cell contains the entire building plan of the whole organism written in the DNA and comprises single genes that determine the specific attributes of the individual.  Gene expression builds tissue cells with tissue-specific attributes. Thus, genes information is activated that forms cells identified as intestinal cells or lung cells etc. In this regulated process methyl groups play an important role. If they are enzymatically bound to a gene’s starting point, known as the promoter, the respective gene is inactivated and the DNA is methylated. As we age and develop age-related diseases such as cancer the activation of genetic information is increasingly defective. However, until now, the detailed processes of these errors and the role of  DNA methylation  in these processes has been poorly understood.

Researchers have known for some time that DNA methylation at the promoter of a gene functions as an on/off switch. However, it was unknown in epigenetics why DNA within the gene body housing the important genetic information is methylated also which was answered in this research. This research showed that genes also aberrant activated if–beyond promoters–DNA methylation is missing within the gene body. Subsequently aberrant proteins are produced that impinge on the cell structure that result in massive disruption of the function and identity of a cell and cell degradation occurs and cancer may emerge.  Researchers concluded “this new knowledge that a lack of DNA methylation at the gene body  may lead to the production of aberrant proteins, might offer a target for cancer therapy. If we succeed to find a way to traffic methyl groups to non-methylated DNA sequences of cancer cells, we could possibly stop proliferation of these cells.”

Can High Risk Breast Cancer Recurrence Patients be Identified?

Friday, September 25th, 2015

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A new study published in the journal Clinical Epigenetics concluded that a new simple blood test might be able to determine the risk of recurrence, or the cancer invading other organs such as the lungs, bone or brain for women successfully treated for breast cancer. Researchers identified 21 DNA hypermethylation hotspots–gene locations along the 3 billion chemical bases of DNA–with increased levels of methylation that could indicate the existence of metastatic cancer.  They said “These findings could lead to a highly sensitive blood-based test panel–a type of liquid biopsy–which could help improve the care of women with breast cancer.” They said further “This 21-gene signature is a potential biomarker that could indicate patients who are at high risk of cancer recurrence, either in the breast or elsewhere in the body, and who might benefit from additional therapy to eliminate the potential of recurrence.” In this study the 21 genes that were differentially methylated were consistently higher in patients with metastatic breast cancer when compared with levels in healthy individuals and cancer free survivors.

 

Can a Blood Test Detect All Types of Cancer?

Wednesday, August 6th, 2014

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New research published online in FASEB Journal, The U.S.Journal of American Societies for Experimental Biology, concluded that a revolutionary blood test that could detect any type off cancer was developed by British scientists. The test6 has been shown to diagnose cancer and pre-cancerous conditions from blood of patients with melanoma, colon cancer and lung cancer with a high degree of accuracy. Researchers assessed white blood cells and measured the damage caused to their DNA when subjected to different intensities of ultraviolet light that is known to damage DNA. They found a clear distinction between the damage to the white blood cells from patients with cancer, with precancerous conditions, and from healthy patients. They also found that  people with cancer have DNA that is more easily damaged by untraviolet light than other people.

Results were based upon blood samples of 206 people of which 94 were healthy and 114 were patients  in specialist clinics prior to diagnosis and treatment. Ultra violet damage was observed in the form of pieces of DNA being pulled in an electric field toward the positive end of the field, causing a comet like tail. The longer the tail the more the DNA damage and this correlated with patients who were ultimately diagnosed with cancer(58) and precancerous conditions (58) and those who were healthy (94). Further clinical research is evaluating the tests accuracy.

Improve Your future with Information From JZ Knight Interview.

Sunday, March 4th, 2012

J Z Knight was interviewed yesterday by Dr Carl O Helvie, Host, the Holistic Health Show.  J Z Knight is  the renowned channel and star of the acclaimed film What the Bleep Do We Know? She is the channel for Ramtha and founder of the Ramtha School of Enlightenment. More information was presented earlier on this blog and can be found at: http://www.ramtha.com and http://www.JZKnight.com Listen to the interview below.