Posts Tagged ‘enzyme’

New Treatment that Effects Lung Cancer Cell Cycles But Does Not Effect Normal Cells.

Friday, May 29th, 2015


A new lung cancer treatment reported in a recent issue of EMBO Molecular Medicine has been in development for 6 years and involves a molecule, RK-33, that interrupts¬† the cell cycle of lung cancer cells without harming normal cells and is effective by itself or in combination with radiation therapy. The researchers designed the RK-33 to bind to DDX3, an enzyme that helps in RNA unwinding and translating RNA into proteins. They also found that RK-33 is involved in DNA repair.¬† Normal cells have many such enzymes, but some cancer cells, including over 90 percent of lung cancer samples studied by the researchers, over expressed DDX3. Binding DDX3 with RK-33 reduces the amount of DDX3 available causing thge cancer cells to die and making radiation therapy, that damages DNA, more effective. The researchers say “We can lowe the dose of radiation significantly but actually get more bank for your buck” by pretreating lung cancer cells with RK-33. Further research is ongoing in multiple cancer types, including breast cancer, prostate, sarcoma and colorectal cancer.

Vitamin D and Lung Cancer Survival

Friday, March 25th, 2011


Recent research in Clinical Cancer Research reports finding an enzyme that plays a role in vitamin D metabolism and can predict lung cancer survival. Comparing the enzyme in subjects with lung adenocarcinoma with those with normal lungs the levels of the enzyme, CYP24A1, was as much as 50 times higher in the lung cancer patients. In addition, the higher the levels of the enzyme, the more likely the tumors were aggressive.
In their sample, about one third of the lung cancer patients had high levels of the enzyme and after 5 years this group had about half the survival rate as the subjects with low levels of the enzyme.
They found that the enzyme, CYP24A1. interacts with calcitrol, the active form of vitamin D, by breaking down calcitrol that has an active role in cancer protection when the enzyme is kept in check, but when levels of the enzyme climbs, it hinders the positive anticancer effect of vitamin D.
Because half of all lung cancers recur following surgery researchers are interested in finding ways to prevent or delay this recurrence. Finding drugs to block the action of the enzyme might allow the positive anticancer effect of the vitamin D to prevent recurrence.

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