Posts Tagged ‘genes’

Can Gene Inactivation Prevent Aging and Cancer?

Wednesday, March 8th, 2017

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A new study published in the journal Nature concluded that every body cell contains the complete DNA library and the so called methyl groups regulate the DNA library in tissues so that only the genetic information needed in that tissue is expressed. Now for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, subsequently may lead to the emergence of cancer.

Each body cell contains the entire building plan of the whole organism written in the DNA and comprises single genes that determine the specific attributes of the individual.  Gene expression builds tissue cells with tissue-specific attributes. Thus, genes information is activated that forms cells identified as intestinal cells or lung cells etc. In this regulated process methyl groups play an important role. If they are enzymatically bound to a gene’s starting point, known as the promoter, the respective gene is inactivated and the DNA is methylated. As we age and develop age-related diseases such as cancer the activation of genetic information is increasingly defective. However, until now, the detailed processes of these errors and the role of  DNA methylation  in these processes has been poorly understood.

Researchers have known for some time that DNA methylation at the promoter of a gene functions as an on/off switch. However, it was unknown in epigenetics why DNA within the gene body housing the important genetic information is methylated also which was answered in this research. This research showed that genes also aberrant activated if–beyond promoters–DNA methylation is missing within the gene body. Subsequently aberrant proteins are produced that impinge on the cell structure that result in massive disruption of the function and identity of a cell and cell degradation occurs and cancer may emerge.  Researchers concluded “this new knowledge that a lack of DNA methylation at the gene body  may lead to the production of aberrant proteins, might offer a target for cancer therapy. If we succeed to find a way to traffic methyl groups to non-methylated DNA sequences of cancer cells, we could possibly stop proliferation of these cells.”

Interviews with Dr Friedemann Schaub (fear and anxiety) and Terri Jay (energy medicine) Now Available.

Sunday, March 29th, 2015

Dr Friedemann SchaubDr Friedemann Schaub is a physician specializing in cardiology and molecular biology who has helped thousands of people with his personal breakthrough and empowerment program that combines his medical training with NLP, time line therapy, clinical hypnotherapy, and more.  His book is Fear and Anxiety Solution: A breakthrough process for healing and empowerment with your subconscious mind. More information at: http://www.cellularwisdom.com

 

Terri Jay

My second guest is Terri Jay, an internationally acclaimed medical intuitive, pet psychic, horse whisperer, energy healer, and more. She has appeared on radio,,, television, and in magazines. More information was presented rearlier on this site and at http://www.terrijay.com

 

Enjoy the Interview below:

 

 

Is a Non-Invasive Method of Early Detection of Colon Cancer Possible?

Friday, September 13th, 2013

logo1267406_mdA new study published in Cancer Prevention Research reports on a new highly sensitive method to detect genetic variations that initiate colon cancer that could readily be used for noninvasive screening for colon cancer. The researcher said “Tumor cells are released into stool from the surface of precancers and early-state colon cancer, but detecting a cancer-intitating genetic mutation among a large quantity of normal ;DNA from a patient’s stool is like looking for a needle in a haystack>” “By combining for the first time locked nucleic acid based, wild-type blocking polymerase chain reactions and high resolution melting, we were able to achieve the desired sensitivity, The extremely high sensitivity of this technique allows us to find very low amounts of different types  of the cancer-indicating mutations in patient ‘ stool samples.”  she continued “Colon precancer cells carrying these genetic variations are routinely shed in stool samples, but these cells can be detected in blood only after the cancer has advanced, so stool is better than blood if we are to catch these cancer cells at a very early stage.”

The method discussed in this study can detect a single cancer-specific gene variation among 10,000 times the amount of normal DNA, and is up toi 5,000-fold more sensitive than other noninvasive screening methods. Sixty human colon tissue samples representing cancers and precancers were used to detect genetic variations using a combination of two techniques. The first locked nucleic acid (LNA) -based, wild type blocking (STB) polymerase chain reaction-suppressed normal DNA present iun large quantities in the sample, and the second technique-high-resolution melting (HRM)-enhanced the detection of genetic variations. They were able to detect APC variations in 41  of the 80 samples and also detected previously unknown variations, In contrast, the routinely used direct sequencing technique detected APC variations in 28 of the  of the 80 samples.

Researchers also analyzed 22 stool specimens from patients whose colon tissue had APC variations, and nine stool specimens from patients without APC in the colon tissue. They were able to detect APC variations in 21 of the 22 samples. “By using our technique for examining a selection of genes that become mutated during the process of colon cancer formation, it is possible to detect the very first stage of colon cancer and even precancers in a stool sample” the research stated. They warned however, that a multicenter study is needed to validate the sensitivity and specificity of this new method in comparison with standard screening methods. (more…)

Can Cancer Virulence Be Predicted”

Wednesday, June 5th, 2013

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Research reported in Science Transitional Medicine concluded that identifying the genes that are abnormally activated in a cancer makes it possible to determine its virulence with great accuracy. Although all cells in the body have the same genes. specialization leads to activation of some and the repression of others. In a cell with cancer the mechanism that allow a cell to activate or repress genes are damaged and there is a sort of identity crisis.  Focusing on genes that are awakened in tumors the researchers found that in almost all cancers, tens of specific genes in the germ line are abhorrently activated. To explore the implications of these aberrant activations the researchers focused on lung cancer. and discovered 26 genes whose activation is associated with particularly aggressive cancers and when these genes are expressed the cancer is very virulent. This allows those cancers that have a high risk of recurrence and a fatal prognosis at diagnosis. Further research should be done on other cancer sites.

Social Isolation and it’s Effect on Breast Cancer

Friday, November 13th, 2009

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Research at the University of Chicago reported in Cancer Prevention Research in October that a ” socially isolated, stressful environment can speed up the growth of breast cancer” in animal models and can actually change the expression of genes involved in the growth of mammary gland tumors Their study followed other studies showing that stress can adversely affect cancer. In their study the researchers randomly assigned mice genetically suceptible for breast cancer to live in social isolation or with groups shortly after weaning. Three and a half weeks later they measured the gene expression in the mammary glands and found reproducible changes in the mice in isolation. These genes that were turned on and off by metabolism are known to contribute to increased breast cancer growth. The mice in isolation developed larger and more cancers than the mice living in groups and had a higher corticosterone stress hormone response than the group living mice. The researcher believes the findings may suggest molecular biomarkers that can be used in prevention in breast cancer and that perceived or actual environmental stressor can affect which genes get turned on or off. If this is proven in further research it may be possible to to find tumors in their formative stage and suppress them before they become tumors.