Posts Tagged ‘metastasis’

Dr Leigh Erin Connealy’s Cancer Revolution Interview

Sunday, March 12th, 2017

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My Guest, Dr Leigh Erin Connealy. M.D. will discuss her new book: The Cancer Revolution A Groundbreaking Program to Reverse and Prevent Cancer

Every year, over 1.5 million people in the US are diagnosed with cancer. Nearly everyone has been touched by this disease—be it their own diagnosis or that of a family member or friend. When faced with the news they have cancer, people start searching for safe and effective treatments. In The Cancer Revolution: A Groundbreaking Program to Reverse and Prevent Cancer, Dr. Leigh Erin Connealy shares integrative medicine techniques, lifestyle approaches, and wellness plans for cancer patients.

Dr. Connealy suggests that it’s not enough to undergo traditional treatments alone. Drawing upon the homeopathic, nutritional, bioenergetics, regenerative, and antiaging disciplines, The Cancer Revolution offers six “Revolutionary Cancer Strategies” to provide better management of cancer, including:

        Let  Food Be Your Medicine ·       Get Moving to Get Well
        Remove Toxins to Boost Your Health ·       Reduce Stress and Reclaim Your Life
·       Harness the Power of Supplements ·       Strengthen Your Immune System with Sleep

By detoxifying, protecting, and providing nutrients to our bodies, Dr. Connealy suggests that we can all lead longer, higher quality lives—even when faced with this formidable disease. She also highlights how these practices can reduce your risk of getting cancer in the first place.

Leigh Erin Connealy, MD, attended the University of Texas School of Public Health and graduated from the University of Health Sciences Chicago Medical School. Her post-graduate training was completed at the Harbor/UCLA Medical Center in Los Angeles. She is the founder and medical director of the Center for New Medicine and the Cancer Center for Healing in Irvine, California. One of the foremost integrative medical doctors in the country, she has been treating patients for nearly thirty years.

Enjoy the Interview Below:

 

 

 

New Method for Killing Metastatic Breast Cancer Cells.

Wednesday, August 31st, 2016

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A new study to be published in Clinical Cancer Research discusses a new way to kill breast cancer cells that are metastasizing  and these cells that spread to the brain, lungs, and bones are the leading cause of death for most cancer patients.  The research discovered how the cells moving to other areas of the body are killed by peptide CT20 that she discovered in 2012.  The peptide CT20 kills the cells by disrupting the folding mechanism inside cancer cells mediated by chaperonin and if the folding mechanism into 3D units is disrupted the cell dies.  Metastatic breast cancer cells have high levels of the chaperonin and the higher the levels the sicker the patient. Multiple strategies can be developed for fighting metastatic cancer cells because of the discovery of how the peptide inhibits the chaperonins folding ability and subsequently  kill cancer cells.  The amount of the peptide that kill cancer cells do not kill normal healthy, non-cancer cells so there will be less traumatic side effects compared to most chemo therapies. A nanoparticle was developed to transport the peptide specifically to metastatic cancer cells.

SEVA Therapeutics, a Massachusetts-based pre-clinical biotechnology company, has licensed the nanoparticle-peptide technology and plans future research to ultimately lead to new therapies. The combo now called SEVA-108, is expected to undergo a comprehensive safety evaluation by the end of this year and clinical trials in patients could start as early as the fourth quarter of 2017.

Epigenetic Regulation of Metastatic Breast Cancer Progression Gene Identified

Wednesday, January 20th, 2016

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A new study published in the journal Proceedings of the National Academy of Science concluded that a gene playing a role in the development of breast cancer metastasis has been identified and may help to predict disease progression and serve as a target for development of future breast cancer therapies.

The gene called serum deprivation response (SDPR) was identified and the mechanism by which it is down-regulated, or silenced, in breast cancer cells promoting tumor spread were discovered. Using a breast cancer progression model, they found that aggressive, metastatic breast cancer cells have little or no genetic expression of SDPR and furthermore when it is over-expressed (turned on) this gene in models of breast cancer cells with propensity to metastasis show a significant reduction in metastatic disease. This study shows the importance of gene regulation by epigenetics instead of genetic mechanisms enabling cancer cells to readily adapt to new micro environments of various organs in the human body at sites away from the initial sites at which the cancer cells formed. Researchers report this work is crucial because the spread of cancer is the major cause of death. They say “It is of utmost importance to understand the underlying molecular mechanisms that facilitate/prevent cancer metastasis.” They continue “While this is a significant advance in deciphering the molecular bassis of metastatic disease and may help to predict progression to metastatic cancer, its potential importance in the development of future precision cancer therapies have yet to be worked out from the identification  of druggable targets regulated by SDPR.”

Can Imaging Techniques Identify Early Metastasis in Lymph Nodes?

Wednesday, May 27th, 2015

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A study published in Cancer Research concluded that a highly sensitive imaging technique for non-invasive screening of lymph nodes for metastatic cancer has been developed that offers a rapid tool for noninvasive identifying cancer spread at its earliest stages based upon testing in mice. The technique uses an imaging approach known as ultrasound-guided photoacoustics combined with nonosensors designed to target and identify metastatic cells in lymph nodes.

Over 90% of cancer deaths can be attributed to metastases directly or indirectly. Currently an invasive surgical procedure called sentinel lymph node (SLN) biopsy is used to identify the region and spread of tumors but the procedure has adverse side effects including pain, numbness and risk of infection. Noninvasive imaging modalities have been tested in animals and patients in order to improve the accuracy and safety of lymph node biopsies. Some imaging techniques such as position emission tomography (PET) and magnetic resonance imaging (MRI) have shown some potential but lack the specificity and sensitivity to be effective. The new technique seems to be more accurate and have improved  sensitivity. Overall, the testing in mice showed a sensitivity of 100% and a specificity of 87% for detection of lymph nodes micrometases as small as 50 micrometers, which corresponds to about 30 metastatic cells. Detection of cells in small numbers in lymph nodes offers a system having the ability to identify metastasis very early in the process, which would allow early treatment. Although these are early studies in mice, the researchers are optimistic about translating the technology for use in humans and expanding the use of the system. More research is planned.

Can a Protein Marker Predict the Spread of Malignant Melanoma?

Friday, April 17th, 2015

Malignant Melanoma and Protein MarkerMalignant Melanoma: A  new study published in Pigment Cell & Melanoma Research concluded that a new protein, megalin, has been found in aggressive malignant cells and might be useful to predict whether and how the cancer will spread and how spread can be prevented. Currently it is not possible to predict which malignant melanomas will spread and it is difficult to eliminate because traditional treatments such as chemotherapy and radiotherapy are mostly ineffective with only 10 percent of patients surviving after reaching an advanced stage with distant metastases. The researchers said “Our studies have shown that the protein megalin is almost always detectable in malignant melanomas, while it is rarely found in the benign counterparts. We see a clear trend that the more megalin is present, the faster the cells divide and the better they are at surviving. This therefore indicates that a high level of megalin in a malignant melanoma should be seen as a warning of particular aggressive cancer cells with extremely good conditions for spreading.” They further said “It is a new and interesting marker that no-one has thought of before……….In a best case scenario, this discovery can pinpoint those patients who will experience a relapsse, and identify which treatment will benefit which patient the most.”

Regarding treatment the researchers say “In general, protein is present at the surface of cells and can absorb many things from the surroundings such as nutrients.  So it is therefore well suited for targeted treatment, either medicine affecting the protein and its functioning thereby inhibiting the proliferation of the cancer cells and their survival, or for transporting lethal drugs into the cancer cells. Since the protein is not found in all of the cells in our body, but in a limited number of places in a healthy individual. this tyoe of treatment can be expected to have less side-effects than the treatment  regime we can offer today.”  More research is ongoing.

 

 

Can the Metastasis of Cancer Cells Be Prevented?

Friday, August 1st, 2014

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In a recent study published in the journal Cell Reports  researchers reported that they successfully performed the first ever block of tumor cells migrating to other sites. They were able to pinpoint a family of pharmaceutical compounds whose action prevents the appearance of tumor metastasis by studying the mitochondria in tumor cells. These organelles are considered to be the cells power station. But when their functioning is altered in tumor cells  the researchers observed that the mitrochondria can promote cell migration that leads to the formation of metastasis.

The researchers examined the molecular mechanism responsible for the mitrochondria ‘s ability to promote metastasis and succeeded in showing that under certain conditions, the mitrochondria produce more free radicals known as superoxide ions and this overpopulation of superoxides  leads to the formation of metastasis and consequently, the growth of a tumor. The production of superoxides by the mitrochondria can be blocked by very specific antioxidants such as MitoTEMPO. When used in models of marine and human tumors, these compounds turned out to be very effective at blocking the migration of tumor cells and preventing spontaneous formation of human tumor metastasis in mice. A clinical study is planned to validate these findings.

Can peaches inhibit breast cancer metastasis?

Wednesday, April 2nd, 2014

logo1267406_mdResearchers in a new study published in the Journal of Nutritional Biochemistry concluded that phenolic compounds in the extract of peaches are responsible for inhibition of metastasis. They said” Cancer cells were implanted under the skin of micewith an aggressive type of breast cancer cells, the MDA-MB-435, and what we saw was an inhibition of a marker gene in the lungs after a few weeks indicating an inhibition of metastasis when the mice were consuming the peach extract.” In addition, they said “After determining the dose necessary to see the effect in mice, it was calculated that for humans it would be equivalent to consuming two or three peaches per day.”

Building upon previous research that showed peaches and plum poly phenols selectively killed aggressive breast cancer cells and not the normal ones, the researchers used a peach variety rich Lady and showed it inhibited metastasis by targeting and modulating the gene expression of metalloproteinases.More research is planned to confirm these results in humans.

 

 

Presence of SPDEF Protein May Prevent Metastasis of Prostate Cancer Cells

Friday, July 13th, 2012

Research published recently in the Journal of Biological Chemistry concluded that prostate cancer cells containing the protein SPDEF  continue to grow at the same pace as their SPDEF- cousins, but these SPDEF+ cells are unable to survive  at possible sites of metastasis.  “It’s as if these cancer cells with SPDEF can’t chew into distant tissue and so are unable to make new homes.”

Researchers studied the homesteading power of cancer cells that have lost SPDEF by introducing a gene into cells that make them glow in the presence of dye and introducing them into the bloodstream of animal models. These cells without SPDEF traveled through the bloodstream and successfully attached to tissue, survived, and fluoresced many weeks later when dye was introduced.  However, those cells with SPDEF flowed through the bloodstream but were unable to attach and successfully establish new colonies and subsequently soon died out.

With future research the researchers hopes to  help doctors recognize prostate cancers that do not require treatment, and to regulate the expression of this protein to remove prostate cancers ability to metastasis. –

Is it Possible to Stop Metastases of Cancer Cells Without Side Effects?

Wednesday, January 18th, 2012

In a new study published in the online edition of Nature researchers conclude that it may be possible to block the formation of secondary cancers in the body. These cancers that have metastasized are often the main cause of complications and death. Instead of focusing on the primary cancer the researchers looked at the development of the metastasized cancers and found a protein that plays a major role in their development. They also found that the secondary cancers could be prevented by blocking the protein.

They found a protein, periostin, in niches where metastases develop and without this protein the cancer stem cells cannot initiate the metastasis but instead, disappear or remain dormant. Periostin, that exists naturally as part of the extracellular matrix is only active in certain organs in adults including the mammary glands, bones, skin and intestine. It seems to play a role in the environment needed by cancer stem cells to develop metastasis because mice that were bred to lack the protein were resistant to metastasis. Researchers said “We developed an antibody that adheres to this protein, making it inoperative, and we are hoping it this way to be able to block the process of metastasis formation.” The researchers found few side effects from blocking the periostin in mice but caution that the results, although encouraging, cannot be assured to be effective in humans without further research.