Posts Tagged ‘research’

Cognitive Behavioral Therapy Effective for Chronic Back Pain

Wednesday, March 10th, 2010

logo1267406_md

In a study published in Lancet 26 February 2010 researchers reported that a type of psychotherapy known as cognitive behavioral therapy (CBT) significantly improves subacute and chronic back pain both short term and for up to 1 year compared to medical advice alone. Seven hundred patients with low back pain were in the study and 468 were treated with up to 6 sessions of group cognitive behavioral therapy and 233 received a 15 minute session of medical management advice that included information on staying active and the appropriate use of pain medications. After 12 months, 59% of those in the cognitive behavioral group reported recovery from their low back pain compared to 31% in the other group. In addition, 65% of those in the CBT group reported satisfaction with their treatment compared to 28% in the other group. The researchers concluded that CBT is a cost effective treatment for low back pin when compared to the cost of chiropractic care, and acupuncture.

Combining MRI and Mammography Screening May Reduce Breast Cancer Deaths for High Risk Women

Friday, March 5th, 2010

logo1267406_md

A new study in the March issue of Radiology reported that combining mammography and magnetic resonance imaging (MRI) may be a cost effective way to reduce the chances of dying for high risk breast cancer women. An increased lifetime risk of developing breast cancer occurs in women with mutations of the BRCA1 gene and using mammography for screening this group (the usual method) detects less than half of the breast cancers.

The researchers compared the cost and benefits of mammography and of MRI’s separately and in combination in a hypothetical group of 25 year old women with BRCA1 mutations. Using a statistical modeling technique to estimate the number of quality adjusted years added by screening and the lifetime costs they concluded that an annual combined screening was best at detecting early stage cancer and at providing the best relative reduction in deaths. Using the combination was most cost effective as the risk of breast cancer increased and least cost effective as it decreased. These findings support the current screening recommendations of the American Cancer Assn.

Miinimally Invasive Procedure May Ease Back Pain

Wednesday, March 3rd, 2010

logo1267406_md

A recent study presented at the annual meeting in Texas of the American Academy of Pain Medicine reported that patients with a variety of back pain conditions could benefit from a minimally invasive procedure called facet arthrodesis. In a prospective study the procedure was used with 102 spine joints in patients who had suffered from recurrent joint mediated low back pain. All subjects had previously had relief following a procedure where heat was used to cut off the nerve supply to the site of the back pain but this relief lasted only about 10 months.
The minimally invasive procedure included a small incision and placing pins by the joints in the affected areas. A bone graft was then placed into the joint and designed to grow into the joint and relieve pain.

a year after the procedure most patients reported a reduction in pain on a visual analogue scale from 79 to 23, and their functions improved on a separate disability index from 33.46 to 8.32. Ninety two percent also reported no longer taking narcotic drugs for pain. The researchers believe this has the potential to be a long term solution for back pain resulting from joint disease.

Aspirin May Reduce Deaths after Treatment for Breast Cancer

Friday, February 26th, 2010

logo1267406_md

A study in the Journal of Clinical Oncology reported that “aspirin can significantly reduce the risk of cancer spread and death in women who have been treated for early breast cancer.” Researchers at Harvard Medical School studied 4,164 female registered nurses taking part in the Nurses’ Health Study. Starting in 1976 they looked at who took aspirin, who developed breast cancer and all causes of death up until 2006. During this time 341 nurses died of breast cancer. Of this group women who took aspirin two to five days a week had a 60% reduced risk of their cancer spreading and a 71% lower risk of breast cancer death. Other non-steroidal inflammatory drugs (NSAID’s) in the same class as aspirin had the same effect and included ibuprofen and naproxen but not acetaminophen. This relationship was not as clear because of limited data. Although aspirin is relatively benign compared with chemotherapy drugs it can cause bleeding and should not be taken without medical supervision. It also should not be taken while undergoing chemotherapy or radiation therapy because of the possible side effects.

Study finds Spinal Adjustment Most Effective Intervention for Chronic Low Back Pain

Wednesday, February 24th, 2010

logo1267406_md

A recent study published in Clinical Rehabilitation compared three treatment interventions with patients having non-specific low back pain. Four hundred forty three patients who reported having non-specific low back pain often or always over a 6 month period were evaluated for the study. Baseline data on pain related disability, pain-related use of medications, and demographic information was collected. Those who had any of the following were excluded: complicating factors such as neurological signs or symptoms, rheumatoid arthritis and other conditions, previous fractures, psychiatric disease, cognitive impairment, or pain-related litigation. The experimental group comprised 210 patients who met all of the eligibility requirements.

Patients were randomly assigned to one of three groups with 70 in each. The groups were: back school, individual physical therapy, and spinal manipulation. The back school group were given 15 hours of group education and exercises for one hour a day on 5 days a week spread over 3 weeks. Classes included training in back physiology and pathology, ergonomics and group exercises.

The physical therapy group received 15 hours of passive and active mobilization, active exercise, massage/treatment of soft tissue and proprioceptive neuromuscular facilitation. The emphasis was on education and active treatment by a physical therapist with the same amount of education and experience as the back school therapists.

The spinal manipulation group attended four to six weekly sessions of 20 minutes each for a total of 80 to 120 minutes of treatment. Treatment was aimed at restoring movement in the vertebral segments by direct and indirect mobilization and manipulation by chiropractors with at least 9 to 12 years of practice.

Two hundred five patients completed the study including 68 in the back school group, 68 in physical therapy, and 69 in spinal manipulation. All three groups reported a significantly lower rate of pain-related disability, subjective experience of pain, and low-back pain related use of medications at the end of the treatment period and after 12 months. Results were most striking for those assigned to the spinal manipulation group. Spinal manipulation provided more functional improvement than the other interventions at the end of the study program and at follow-up one year later as measured by lower scores on the Roland Morris Disability Scale. Their average score was 1.6 compared with 5.9 for the back school group and 5.3 for the physical therapy group. There was also less need for medications among this group than the others as measured by a 49% reduction in the need for pain medications in this group compared to a 23% drop in the back school group, and a 14% drop in the physical therapy group.

Diet May Protect Against Lung Cancer in Current and Former Smokers

Friday, February 19th, 2010

logo1267406_md

A new study reported online January 12, 2010 in Cancer Research concluded that leafy green vegetables, folate, and some multivitamins may serve as a protective factor against lung cancer in current and former smokers. This first step in understanding a complex association was funded by the National Cancer Institute.

Researchers studied more than 1,100 current and former smokers who submitted sputum specimens and completed questionaires about their dietary intake. Most of the sample (75%) were women. Sputum samples were examined for the methylation status of eight genes that are linked to the increased risk of lung cancer in previous studies. Gene Methylation is believed to be a major mechanism for lung cancer development and progression and also a potential marker for the early detection of lung cancer.

The researchers investigated the association between 21 dietary variables and methylation and found that higher intakes of leafy vegetables and folate were significantly associated with a reduced probability of high methylation. Additional research is needed to validate these findings.

Cognitive Therapy Useful in Chronic Pain

Wednesday, February 17th, 2010

logo1267406_md

Current research published in the journal Sleep Medicine concluded that cognitive therapy can significantly improve sleep for patients with chronic neck and back pain and relieve pain so they can perform more normal daily activities. This included patients who were on medications but did not want to take more for an sleep disturbances.

A nurse therapist delivered eight weeks of cognitive -behavioral therapy including sleep restrictions, stimulus control, sleep hygiene, and a discussion of catastropic thoughts about the consequence of insomnia. They talked about habits such as the use of caffeine or alcohol, and the use of the bed only for sleeping or sex. A user-friendly manual describing each step was developed that can be used to train other therapists.

Twenty- eight patients participated in the study. They kept sleep diaries, reported on pain and mood standardized tests, and were followed for 6 months after the in intervention. Further research is ongoing to determine the duration of the effects of treatment.

Reduce Lung Cancer Risks With Soy Products

Friday, February 12th, 2010

logo1267406_md

A new study published in the American Journal of Clinical Nutrition reported that along with stopping smoking a diet rich in soy lowers the risk of lung cancer in men. In addition to previously know soy isoflavones having anticancer properties in breast and prostate cancer the research now extends soy to lung cancer. The researches believe that men who use soy products may also participate in other activities that lower the risk of lung cancer. Although more studies are needed to comfirm these results their results show that non-smoking men who use soy products are less likely to develop lung cancer.

New Approach May Halt or Reverse Rheumatoid Arthritis

Wednesday, February 10th, 2010

MVC-890S

New research to be published in the February issue of Arthritis & Rheumatism discussed a novel way to halt or reverse rheumatoid arthritis by using am imitation of a suicide molecule that floats undetected into immune cells that are responsible for this type of arthritis. Using this approach the researchers were able to stop the disease in 75% of the study mice without any observed toxic effects as is the case with current drugs. The mechanism is that healthy immune cells usually die after attacking an invading virus or bacteria. However, in rheumatoid arthritis the immune cells do not die but live on and go rogue proliferating in the blood, building up in the joints and invading cartilage and bone.

Researchers discovered that immune cells in rheumatoid arthritis are low in a critical molecule (Bim) that cause the immune cells to self- destruct. To correct this fault they developed an imitation of this molecule (called BH2) that was injected into study mice with rheumatoid arthritis that caused the immune cells to destruct, joint swelling was reduced and bone destruction decreased. Thus, they concluded that the molecule could prevent the disease and trigger a remission in those who have it. Further research is planned to develop a more precise method of delivering the drug.

Strength Training, Self-Management Programs or a Combination are Equally Effective for Osteoarthritis

Wednesday, February 3rd, 2010

logo1267406_md

A 24 month unblinded, random intervention study to compare the effects of strength training programs, self-management programs, and a combination of both carried out at the University of Arizona Arthritis Center found that physically inactive, middle aged people with symptomatic osteoarthritis benefited equally from strength training regimes, self-management programs, or a combination of the two. In this study, known as the Knee Study the researchers hypothesized that combining the two treatments might enhance the outcome.
Two hundred seventy three study participants between the ages of 35 and 65 who had reported pain and disability due to knee pain on most days in one or both knees for a period of not more than five years, and had a Kellgren/Lawrence classification grade 2 radiographic evidence of knee osteoarthritis in one or both knees were included.
Study participants were randomly assigned to 1 of 3 treatment groups-strength training, self management program, and the combination group. The strength training group spent the first 9 months improving the core areas of stretching and balance, range of motion and flexibility, and isotonic muscle strength. This was followed by 15 months of developing independent, long-term exercise habits. The second group participated in a 2-phase self-management program to educate participants and provide one on one treatment advice. The combined group participated in both the complete training and self-management program. Two hundred one of the original 273 participants completed the two year program with the self management group having the highest compliance rate.

Despite the lack of differences in finding in the three groups, all groups demonstrated improvements in physical function tests and decreased self-reported pain and disability. The researchers stated that because the self management group demonstrated higher compliance and there was no differences found in the outcome of the three groups, self-management might be a less intrusive and equally effective early treatment for knee osteoarthritis. More information is available in the January 2010 issue of Arthritis Care & Research.