Research presented at the annual meeting of the American Society of Clinical Oncology in Chicago on June 4 concluded that metastatic prostate cancer patients who received a vaccine made from their own frozen immune cells lived up to 10 months longer than those who did not receive this intervention. In this exploratory study immune cells (APC8015F) are taken from prostate cancer patients before the disease progresses and frozen. Results showed that following progression, those treated with APC8015F had a median survival rate of 20 months compared to 9.8 months for those not treated with APC8015F. Further research is planned.
Posts Tagged ‘survival’
Experimental Study Shows Increased Survival of Prostate Cancer Patients Using Frozen Immune Cells
Friday, June 10th, 2011Shorter Head and Neck Cancer Patient’s Survival Associated with Stress and Depression
Friday, May 6th, 2011In a study presented at the 32nd Annual Meeting and Scientific Sessions of the Society of Behavioral Medicine last month, researchers found an association between survival in early stage cancer patients and psychosocial function. Following upon research that shows that stress can affect the immune system and weaken the cancer patient’s defenses and also affect the tumors ability to grow and spread the researchers found that poor psychological functioning was associated with greater vascular endothelial growth factor (VEGF) expression. This signaling protein stimulates tumor growth and is associated with shorter disease-free survival in head and neck cancer patients.
In their study, 37 newly diagnosed, pre-surgical head and neck cancer patients were evaluated to see if psychological functioning (perceived stress, social support and depression) was associated with VEGF. Subjects were mostly male (70.3%). average of 57 years of age, and with a primary tumor site in the oral cavity (65.9%), larynx (19.9%). and oropharynx (13.5%), and early-stage disease (over 40%).
Subjects were given a psychological questionaire prior to treatment that measured psychological functioning. In addition, VEGF expression in tumor tissue was obtained during surgery and evaluated using a process that helps detect the presence of specific proteins. Results showed that higher levels of perceived stress and depression symptoms were associated with greater VEGF expression in the tumor tissue of these patients and the association between psychological functioning and VEGF were stronger among early-stage subjects. Researchers concluded that “In patients with advanced cancers, psychosocial interventions may have less of an impact since these cancers are inherently more aggressive.”
More research is planned.
Outcome of Physical Limitations on Long Term Survival of Breast Cancer Survivors
Friday, October 1st, 2010
In a new study published in the online Journal of the National Cancer Institute researchers concluded that basic physical limitations after breast cancer treatment may affect the individuals length of survival. They found that breast cancer survivors who had functional limitations defined as an inability to perform normal daily activities as a result of their disease or its treatment were more likely to die of overall poorer health despite having the same risk of dying as other breast cancer survivors without limitations. Functional limitations that affected up to 39% of the survivors in this study were more often seen in obese breast cancer patients or older women. With changes in habits that allowed more physical activity their health and length of survival might be improved.
Impairments studied were motion, strength and dexterity and included activities such as an inability to kneel, lift items heavier than 10 pounds, handle small objects, stand in place, sit for long periods, walk up and down stairs or walk two or more city blocks. The researchers believe that developing interventions to improve physical functions such as walking around the block, carrying a heavy bag of grocery or rising easily from a chair might reduce the harmful outcomes.
In this study 2,202 women with breast cancer were questioned about endurance, strength, muscular range of motion, and small muscle dexterity after having treatment with chemotherapy, radiation, hormone replacement or other therapy. They were followed for up to 11 years. Outcomes differed depending upon the disease stage and those with localized cancer had higher rates of non-breast cancer deaths due to functional limitations than those with more advanced disease. Researchers believed the sample may have been biased to include more older and obese women in the localize group who tolerate treatment less well accounting for these findings. However, they conclude “women with functional limitations ……..would likely benefit from interventions to reduce their limitations and increase physical activities.”
Shark Cartilage and Lung Cancer
Friday, June 4th, 2010A study published in the Journal of the National Cancer Institute on May 26 concluded that shark cartilage showed no benefit for advanced non-small cell lung cancer when combined with chemotherapy and radiation. In this Phase III study 379 newly diagnosed untreated Stage III non-small cell lung cancer patients from 53 sites in the United States and Canada were enrolled between June 2000 and February 2006. Using a randomized design patients were given either shark cartilage or a placebo, both in the form of a liquid. Subjects drank 4 ounces of the extract twice daily during and following standard treatment. With a median 3.7 years follow up, researchers did not find a significant difference between those receiving the shark cartilage (14.4 months) and those receiving a placebo (15.6 months). The lead researcher concluded ” these results demonstrate that AE-941 is not an effective therapeutic agent for lung cancer.”




