DNA and Key Enzymes Damaged by Smokeless Tobacco

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In a report in the journal Chemical Research in Toxicology researchers concluded that smokeless tobacco not only has adverse affects on the mouth but also affects the normal functioning of a key family of enzymes found in most organs of the body and DNA. Functions of these enzymes include production of hormones including estrogen and testosterone, production of cholesterol and vitamin D, assisting with breakdown of prescription drugs and potentially toxic substances. The smokeless tobacco also damages genetic material in the liver, kidney and lungs. These conclusions were a result of changes observed in enzymes and genetic material in laboratory rats using extracts of smokeless tobacco.

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