Vitamin D and Allergy Prevention and Treatment to Common Mold

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In a report published early online that will appear in the September issue of the Journal of Clinical Investigation researchers concluded that vitamin D may be an effective treatment for preventing or treating allergy to a common mold, Aspergillus Fumigatus, that can complicate asthma. Although this fungus is one of the most prevalent it usually is not associated with diseases but in asthmatics and patients with Cystic Fibrosis it may cause significant symptoms. Focusing on patients with Cystic Fibrosis who more often develop severe allergic reactions Studying two groups of patients with cystic fibrosis they found that when colonized with A. Fumigatus only one had the severe allergic response. The difference was in the level of vitamin D in the blood. By adding vitamin D they were able to substantially reduce the production of proteins driving an allergic response and also increased the protein that promoted tolerance. A clinical trial is planned to see if vitamin D can be used to treat or prevent the allergic complications of asthma and Cystic Fibrosis.

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