Risk of Triple-Negative Breast Cancer May Be Increased by Obesity

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Research published in Cancer Epidemiology: Biomarkers & Prevention confirmed that obesity and lack of physical activity increase the risk of triple-negative breast cancer among women. Triple-negative breast cancer accounts for about 10 to 20 percent of all breast cancers, has a poor prognosis. and is a subtype of breast cancer characterized by a lack of estrogen, progesterone and HER2 expression.

The researchers analyzed data from over 155,700 women enrolled in the Women’s Health Initiative. Assessing levels of baseline body mass index (BMI) and recreational activities among 307 women with triple-negative breast cancer and 2,610 women with estrogen receptor-positive breast cancer they found that women with the highest BMI had a 35% increase risk of triple-negative breast cancer and a 39% increased risk of estrogen receptor-positive breast cancer. While evaluating the role of exercise they found that those who reported
high rates of physical activity had a 23 percent decrease risk of triple-negative breast cancer and a 15% decrease risk of estrogen receptor-positive breast cancer.

More information is available at:

http://www.sciencedaily.com/releases/2011/03/110301142011.htm

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