Is there an Association between a High-Fat, High Caloric Diet and Pancreatic Cancer?

logo1267406_mdA new study published in the journal Cancer Prevention Research concluded that mice made obese by being given , high-fat, high-calorie diets (HFCD) developed abnormally high numbers of lesions known as pancreatic intraepithelial neoplasies (PaniNs) that are known to be precursors to pancreatic cancer. Thus, being the first study to show a link bewtween obesity and the tisk of pancreatic cancer (one of the most deadly forms of cancer) in an animal model.

Researchers studied diet-induced obesity and the development of pancrea cancer in a set of mice and then compared them to another set of mice that were genetically identical but not given the high-fat, high calorie diet. They also assessed the impact of the effects of the high-fat, high calorie diet on mouse pancrea tissue, such as an increased inflammation and other signs of pancreatic problems. TheseĀ  indicators were measured to creaste an overall score (pancreatitis-score) to indicate negative effects on the pancreas. They also studied pancreatic tissue to determine how many PaniN precursor leisions had developed.

Mice eating the normal diet gained approximately 7.2 grams over 14 momths whereas those who ate the high fat/high calorie diet gained an average of 15.9 grams and mice fed the normal diet had mainly normal pancreas with very few scattered PaniN lesions but the mice fed the high fat.high calorie diet had significantly more PaniN leisions and fewer overall healthy pancreas. The study showed mice on the high fat/high calorie diet gained significantly more weight, had abnrmalities of their metabolism and increased insulin levels, and had marked pasncreatic tissue inflammation and development of PaniN leisions. ThisĀ  strongly suggest that a diet high in fat and calores leads to weight gain, metabolic disturbances, can cause pancreatic inflammation, and promotes pancreatic leisions that are precursors to cancer according to the researchers.

 

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