Some Heart Problems May be Related to A Commonly Used Antibiotics

A new study published in the Journal of the American College of Cardiology  concluded that current users of fluoroquinolone antibiotics, such as Ciprofloxacin or Cipro, have a 2.4 times greater risk of developing aortic or mitral regurgitation compared to patients taking amoxicillin, a different type of  antibiotic. This greater risk occurs within 30 days of use.  Recent studies have also liked the same class of antibiotics to other heart problems. Some physicians prefer tis class of antibiotics over others bewcvause of their broad spectrum of antibacterial activities and high oral absorption, which is as effective as intravenous treatment.

For the study researchers analyzed data from the U S Food  and Drug Administration’s adverse reporting system and a massive private insurance health data claims database in the U S that collects demographics, drug identification, dose prescribed, and treatment duration.  Researchers identified 12,505 cases of valvular regurgitation with 125,020 case-controlled subjects of move than nine million patients in a random sample.  They defined current floroquinolone exposure as an active prescription or 30 days prior to ther adsverse event, recent exposure as within 31 to 60 days, and past exposure as within 61 to 365 days prior to an incident. Flouroquinolone was compared with amoxicillin and azithromycin.  Results shjowed that the risk of aortic and mityral regurgitation, blood backflow into the heart, is highest with current use, followed by recent use. The found no increased risk aortic or mitral regurgitation with past use.

 

Tags: , , ,

Comments are closed.