Archive for the ‘immune system’ Category

Alzheimers-Here today. Gone tomorrow. Good News.

Sunday, November 19th, 2017

 

 

 

 

 

 

Dr. Dale Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO.  Dr Bredesen has mentored many, many physicians and PhD learners in his lab, presented over 300 papers, written over 200 peer reviewed papers written numerous book chapters and abstracts,, written several books including his recent the End of Alzheimer’s: The first program to prevent and reverse cognitive decline, received numerous patents and honors. In addition, recently he has been interviewed on many television  and radio shows including Dr Oz. You can see his curriculum vitae at: https://docs.wixstatic.com/ugd/1a2e49_f0a51bffa9a341dca2ab7af9b6fd0c3d.pdf

The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain — promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials.

Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age.

Listen to the Interview below:

 

 

Inflammation-Dr David Seaman and Cellular Expansion-Patti McNulty

Sunday, February 12th, 2017

DrDSeaman

My next show on Saturday at 12 noon PST will include the following guests.

Dr. David Seaman was the first person to author a scientific paper that specifically hypothesized that diets can be pro-inflammatory or anti-inflammatory. Since that paper was published in 2002, thousands of papers and numerous books have been published on the topic of diet and inflammation, which is now accepted as mainstream.

Dr. Seaman is a Professor of Clinical Sciences in the Chiropractic Medicine program at National University of Health Sciences in Pinellas Park, Fl. He has a BS from Rutgers University in 1982; a Doctor of Chiropractic from New York Chiropractic College in 1986; and a MS in Bio/nutrition from the University of Bridgeport in 1991

While in clinical practice in the late 1980’s, he became aware of the developing research that linked nutrition to the inflammatory process and noticed that appropriate dietary changes could significantly improve various musculoskeletal and visceral conditions. Based on this experience, he began to focus on nutritional approaches for inflammation/pain control and has followed the related scientific literature ever since. This led to the publication of the first book on nutrition for pain and inflammation, which was followed by many articles and book chapters devoted to this topic. His educational efforts resulted in being awarded the 2006 Academician of the Year by the American Chiropractic Association.

P McNulty

Patti McNulty began her education with four years of intensive training in a combined mental health/addictions and family counseling program. Subsequently, she spent twelve years providing both inpatient and outpatient addiction services to a range of psychiatric hospitals. She was then the primary Employee Assistance Program counselor for JFK and LaGuardia Airports in New York, where employees could receive counseling and addictions treatment on-site.

In 1996, she was awarded a New York State citation for her work with the survivors and employees involved in the Flight 800 plane crash that same year. Her work experience pulled her in the direction of not only further addictions treatment work, but also in trauma work in addicted populations.

In 2005, she became a holistic studies practitioner, completed two graduate programs at the School of Vanati in Pittsburgh, and is presently involved in the extension graduate program.

Patti started working at Serenity Acres Treatment Center in January of 2013, as a licensed Certified Associate Counselor for Alcohol and Drugs (CAC-AD), and provides addictions counseling, family education, and holistic therapy services to her clients. She also runs her own business, Healing Branches, in Severna Park, Md. At Healing Branches, Patti practices Cellular Expansion and Healing Energy Medicine—a form of hands on bodywork that heals through the cells for optimal health and wellness.

Enjoy the interview below:

 

 

Does your Place of Residence influence your Immune System?

Friday, October 7th, 2016

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In a recent issue of Trends in Immunology researchers concluded where and with whom we live account for 60 to 80 per cent of the differences between individual immune systems, while genetics account for the rest. Like fingerprints, immune systems vary from person to person and despite our unique set of genes that help us respond to infections our diet, quality of air, food, stress levels, sleep patterns and lifestyle choices have a stronger effect on our immune system. The researchers said “Just like it took a while to crack the genetic code, we’re finally starting to crack the immune code, and we’re shifting away from the simplistic idea that there is only one type of immune system. diversity isn’t just programmed into our genes–it emerges from how our genes respond to their environment.”

They say that long-term infections are responsible for most of the differences between individual immune systems and use the example of herpes or shingles. In these processes the virus has more opportunity to interact with the immune system and these interactions slowly change the cellular makeup of the immune system and make it more sensitive to that specific virus but also easier for other infections to move past its defenses. People who do not have these infections don’t experience cellular changes, and even with the occasional cold or fever, their immune system stays relatively stable over time.

The exception is an elderly person when our immune system reacts differently to threats. This is related partially to the thymus organ that gradually stops producing T cells, which are made to fight infections. Without these cells, older people are more likely to get sick and less likely to respond to vaccines. In addition, to the lack of T cells there seems to be other changes in the way the immune system reacts. For example, the researchers say “A lot of diseases we associate with aging have an inflammatory component, which suggests there is likely immune involvement.”  The further say differences can be overcome and studies of people living together show that air-quality, fod, stress level, sleep patterns, and lifestyle choices had a strrong combined effect on immune responses and couples who cohabitate had more similar immune systems compared with the general public.  Researchers now plan to study how changing the envorinbment could purposefully shape our immune system and potentially effect our health.