Archive for the ‘prostate cancer’ Category

Metastatic Prostate Cancer predicted with new Biomarker in Lab. .

Wednesday, November 22nd, 2017

Many.prostate cancers that are usually diagnosed in older men are slow growing and not considered fatal.  But some become aggressive and spread beyond the prostate, making them difficult to treat and life-threatening. With current knowledge doctors are unable to determine which will be slow growing and which will spread to other sites. In this study published recently in Clinical Cancer Research  report discovering a genetic signature .within prostate cancer that can predict which tumors are likely to metastasize.

Using several data sets of prostate cancer patients and outcomes researchers found that a high number expressed two genes:  TOP2A and EZH2 were associated with early recurrence of prostate cancer and metastatic spread leading to an increased risk of death. Strong metastatic tendencies were only expressed if both genes were found in the tumor. Researchers said: “Altogether we found that high levels of TOP2A and EZH2 expression consistently associated in the progression to a metastatic and lethal disease. ”

Using mouse prostate cancer cells in the lab, researchers found that cells containing overexposed  TOP2A and EZH2  genes were highly sensitive to attack with a combination of 2 drugs. However, clinical trials are necessary to make a definitive statement. It is hoped that attacking these genes with drugs may prevent aggressive cells from p metastasizing. . 

Can Therapy for Prostate Cancer Increase Risk of Alzheimers

Wednesday, December 9th, 2015

Logos 005A new study published in the Journal of Clinical Oncology concluded  that men taking androgen deprivation therapy (ADT) for prostate cancer were almost twice as likely to be diagnosed with Alzheimer’s later in life than those who did not use the therapy based on the analysis of medical records. In addition, men with the longest duration of using ADT were even more likely to suffer Alzheimer’s. Researchers said this does not prove that ADT increases the risk of Alzheimer’s but point to that possibility and are consistent to other evidence that low levels of testosterone may weaken the brain of aging individuals resistance to Alzheimer’s.  The researchers said “We wanted to contribute to the discussion regarding the relative risk and benefits of ADT. and no one had yet looked at the association between ADT and alzheimer’s disease.” “Based on the results of our study, an increase risk of Alzheimer’s disease is a potential adverse effect of ADT, but further research is needed befre considering changes to clinical practice.”

For this study, the researchers evaluated large sets of medical records from two hospitals on the east and west coasts.  In total, there were about 5 million patients. of whom 16,888 had a diagnoses of prostate cancer and met the other criteria of the study. Of the 16,888 prostate cancer patients about 2,400 had received ADT and had the necessary follow up records. This group was compared with a control group of prostate cancer patients who did not receive ADT that were matched by age and other factors.

Using two different statistical analysis methods, the researchers  showed that the ADT group , xompared to the control group, had significantly more Alzheimer’s diagnoses in later years and showed that the ADT group were about 88 percent more likely to develop Alzheimer’s during the follow up period. Further studies are planned  to determine whether ADT does increase Alzheimer’s risk using data from large cancer registries.

Does Soccer Strengthen Bones of Men with Prostate Cancer?

Wednesday, December 2nd, 2015

Logos 005A new study published in Osteoporosis International and European Journal of Applied Physiology concluded that men with prostate cancer run the risk of brittle bones as a result of their treatment but football training a few times a week counters many of the effects of the treatment. They say that being challenged by an opponent, changing direction, kicking and blocking the ball provides a wide range of stimuli to the bone tissue making them stronger. They add that soccer training is  not just good for the heart and muscles but also strengthens the bones because of the running around the pitch, jumping, accelerating, braking and kicking the ball.

In the study 57 men aged between 43 and 75, with an average age of 67 participated. All were receiving treatment for prostate cancer. After drawing lots the participants were divided into a soccer training group and a control group. The soccer group trained 2 to 3 times a week for 12 weeks, 45 to 60 minutes at a time. Before starting and after 12 and 32 weeks’ training both groups were tested with functional tests, blood sampling, and DXA scanning.

During training the players movements were tracked precisely with GPS. Measurements showed an average low speed for the players but they performed 300 deceleration’s, 200 accelerations, and 100 running bouts per hour of soccer training session which is believed to be the reason that soccer is better for the bones than jumping on and off a step bench, for example.

Researchers said “The change in bone mass in the legs of the soccer group showed a significant correlation with the number of times they accelerate and brake. This gives an indication that the effect is linked to the specific activity that we see in soccer, where there is interval running with a lot of accelerating and braking which place great stress on the bone tissue, and that is what makes them strong.” A small umber sustained injury from the football and the gains should be weighed against this loss.

Can Yoga Lessen the Side Effects of Traditional Cancer Treatment?

Wednesday, November 25th, 2015

logo1267406_mdA new study presented at the Society of Integrative Oncology’ International Conference in Boston concluded that yoga may benefit men who are undergoing radiation therapy for prostate cancer. Side effects often experience include fatigue, erectile dysfunction, urinary incontinence and a decline in quality of life.

In this small study of 27 men who attended 75 minute yoga classes twice a week expressed no decline in quality of life or experienced any side effects through the radiation therapy. Researchers said “Data have consistently shown declines in these important measures among prostate cancer patients undergoing cancer therapy without any structured fitness interventions so the stable sc0res seen with our yoga program are really good news.” The researchers believe the yoga may help the fatigue and may strengthen the pelvic muscles and increase blood flow that may improve erectile dysfunction and urinary incontinence. They also thought the group participation might provide a psychosocial benefit. Previous studies have shown that yoga was beneficial for breast cancer patients.

Better Assessment of Treatment Options for Prostate Cancer Patients.

Tuesday, November 24th, 2015

Better Assessment of Treatment Options for Prostate Cancer Patients

Prostate Cancer Treatment Options: Research reported in JAMA Oncology reported that regardless of aggressiveness of the tumor, risk to the patient, and overall patient prognosis, radiation therapy was the most common treatment for men with prostate cancer. This finding was based upon an analysis of claims data of over 37,000 patients over a three year period between 2004 and 2007. Radiation therapy was used for 58 percent of the patients. followed by 19 percent for radical prostatectomy (a surgical procedure to remove the prostate) and 10 percent for oi=ther treatments including watchful waiting and active surveillance. Researcher said patients must consider recommendations of the physician, the aggressiveness of their cancer, whether active surveillance is preferred over treatment, and the health care costs. They found that the main predictor of a man receiving radiation was a referral to a radiation oncologist. On the other hand, urologists and surgeons significantly recommended surgery only after incorporating the patients age, health and the aggressiveness of the cancer.

Researchers said “Doctors and patients view radiation as safe. There’s  no anesthesia or hospitalization, the patient comes in for 15 or 20 minutes for the daily radiation treatment, it’s localized to a specific area, then they get to go home.  They often don’t notice any immediate effects upfront.” But by two years after  treatment, men often begin to suffer from side effects including urinary incontinence and leakage of urine, anal leakage and bowel dysfunction, erectile dysfunction, blood in the urine, and radiation cystitis.  These may vary from mid to serious.

New Tool for Predicting Survival and Staging of Prostate Cancer.

Friday, October 16th, 2015

Improved Diagnostic Test for Prostate Cancer.

Wednesday, May 20th, 2015

Improved Diagnostic Test for Prostate Cancer

A new study reported in Science digest concluded that a new urine-based test for prostate cancer improves detection when compared to prostate serum antigen (PSA) levels. This test also improved detection of the more aggressive forms of prostate cancer. The new test is called Mi-Prostate Score (MiPS)  and combines the PSA with two prostate cancer markers-T2:ERG and PCA3 both of which can be detected through a urine test.  The test was indicated because about 50% of all men having biopsies will not have cancer.

In the study 1,977 men having the prostate biopsy because of elevated PSA levels were evaluated. Researchers used urine samples to conduct MiPS testing and compared with various combinations of PSA, PBA3, T2:ERG and other PSA-based calculations. The testing evaluated how well individual biomarkers and combinations predicted the likelihood of cancer and high-risk cancer.  Although there is no one cut-off score  for a positive result, they found that using one MiPS cutoff score to decide whether or not to biopsy patients would reduce the number of biopsies by one-third, while delaying the diagnosis of only about 1 percent of high-risk prostate cancers. More research is ongoing.

One dollar blood test using gold nanoparticles more effective than PSA test in prostate cancer detection.

Wednesday, April 8th, 2015

Prostate Cancer Detection with gold nanoparticles

A new study published in ACS Applied Materials & Interfaces concluded that a test using gold nanoparticles to detect early stage prostate cancer costs less that $1, has results in minutes and is more accurate than standard PSA screening. The gold particles attract cancer bio markers. The researchers test detects the immune response that the body produces in response to the development of a tumor. The gold nanoparticles are about 10,000 times smaller than a freckle.  When blood from a finger prick is mixed with the gold nanoparticles, certain cancer biomarkers cling to the surface of the tiny particles. increases their size and causes them to clump together. In the test they are able to measure the size of the particles by analyzing the light thrown off and the size reveals whether or not the patient has prostate cancer and how advanced it may be. Researchers said “Whats different and unique about our technique is it’s a very simple process, and the material required for the test is less than $1. And because it’s low cost, we’re hopinf most people can have this test in their doctor’s office. If we can catch this cancer in its early stages, the impact is going to be big.”

Evaluation of the test determined at 90 to 95 percent that it is not false positive, and with 50% confidence that it is not false negative which is higher than the PSA confidence in false positive at 20%. More research is planned with the eventual goal of hqving a simple, cheap test for various cancer types.

A common Prostate Cancer Treatment Reduces Survival in Older Men.

Wednesday, December 10th, 2014

logo1267406_md

A new study published in European Urology concluded that a common prostate cancer therapy known as ADT should not be used in men whose cancer has not spread beyond the prostate  Researchers found that the therapy exposed them to more adverse side effects and was associat3d with increased risk of death and deprived the men of the opportunity for a cure by other methods.

ADT or androgen deprivation therapy involves injecting or implanting medication that disrupts the bodies ability to make testosterone and has significant side effects such as heart disease, diabetes, increased weight gain and impotence and potential earlier death.

According to the authors  the treatment has become a mainstay for prostate cancer that has metastasized or spread beyond the prostate gland. and others used it with radiation therapy. However, the authors say there is no evidence for use of ADT for low risk or localized prostate cancer despite its use in these patients. This misuse of ADT therapy lead to changes in Medicare reimbursement policires for ADT in 2004 with a resulting 40 per cent drop in reimkbursement and a reduction in inappraopriate uise of ADT from 38.7 percent to 25.7 percentfor newly diagnosed localized prostate cancers. The current study  study ” hypothesuized that adverse effects of ADT might be more pronounced in men with longer life expectencies since they would likely be treated with ADT for a longer period and be exposed to more treatment-related side effects. ” Of a  population of 46,376 men diagnosed with localized prostate cancer who did not undergo radical prostectomy or radiation therapy for prostate cancer diagnosed between 1992 and 2009 thirty eight and a half percent were treated with ADT and the hypothesis was confirmed. Findings showed that primary ADT was associated with decreased survival in men with localized prostate cancer relative to men who received noa ctive treatment. Thus, ADT should not be used as a primary treatment for men with prosatate cancer that has not spread beyond the prostate or men with moderate or high disease undergoing radiation therapy.

New Diagnostic Test for Prostate Cancer.

Friday, October 31st, 2014

logo1267406_md

After 30 years without progress in screening methods a new screening test has been identified for detecting prostate cancer. The  only place in the southeast part of the United States that offers the new technique–the MRI-US image fusion technique-is the University of Alabama in Birmingham. The researchers say ” We are utilizing prostate MRI and fusing it with real time ultrasound for image-guided prostate biopsies;  this can detect prostate cancer with high accuracy, and it accurately targets lesions of concern defined by MRI. ” ” This improves overall detection compared to standard biopsies and, more importantly, has the potential to give clinicians and patients a more accurate picture of their true disease burden by allowing improvements in staging.” The new technique allows direct tissue sampling of suspicious areas seen on MRI as opposed to the traditional method of random, systematically sampling that is essentially performed blind in different regions of the prostate.

Researchers say studies show the technique increases the overall cancer detection rate, increases the high risk detection rate, and improves staging for patients who are considering active surveillance where the doctor monitor low risk prostate cancer for changes.  the technique is a clinical based  procedure that can be performed under local anesthesia and the patient’s experience of this new biopsy compared to previous biopsy without MRI guidance is the same but with more accurate outcomes based on the targeted approach. The procedure has been offered for the past year at the U of Alabama.