Posts Tagged ‘animal studies’

Glioblastoma Research Shows Tumor Cell Death in Cell and Animal Studies Using Antihistamines.

Wednesday, July 17th, 2019

A new study published in EMBO Molecular Medicine Journal concluded that “antihistamines and other drugs that increase the permeability of the lysomal membrane can be considered as an enhancing therapy for patiets with glioblastoma alongside established treatments.” In the research they found that “glioblastoma cells depend upon the expression of a gene which produces the MDGI protein (small fatty acid binding protein). Inhibiting of this gene results in the death of the tumor cells.” The absence of MDGI causes instability in the membranes of lysosomes, cleaning organelles found inside tumor cells, and in turn, resulting in the leakage of acidic and proteolytic enzymes contained in the lysosomes into the cytoplasm, initiating cell death. Reasearchers said their research “demonstrates that MDGI  is a key factor regulating and maintaining the structure of the lysosomal membrane. This is the first gene found to regulate the stability of the membrane.”  Their results are especially interesting because they found that cell death caused by leakage in the lysosomes of glioblastoma can be activated by using drugs that cross the blood-brain barrier” and in this study they used the antihistamine clemastine.

In cell cultures the antihistamine in lysosome-initiated cell death in glioblastoma cells were at concentrations that has no significant effect on healthy cells of different types.  In mouse models it was effective in reducing the spread of brain tumors and improving the survival rates of the animals. In the most invasive brain tumor model, the antihistamine resulted in the disappearance of the entire tumor.

 

 

 

An International Alternative Cancer Leader, Frank Wiewel, Interviewed.

Sunday, July 2nd, 2017

For nearly 40 years, Frank Wiewel and his wife Denise have led the struggle for medical freedom in America and throughout the world. Frank was a successful Columbia Records recording artist, engineer and producer. In July 1985, he happened to be in Freeport, Bahamas, accompanying his sick father-in-law, when the Bahamian government, at the instigation of the United States National Cancer Institute (NCI) shut down Dr Lawrence Burton’s (IAT) cancer clinic.

The IAT patients organized and asked Frank to become first president of their association. Frank and Denise led them in a march on Washington and drafted the petition for an evaluation of innovative therapies, signed by 43 Congressmen. Frank was the original requestor of this Office of Technology Assessment (OTA) study entitled, Alternative Cancer Therapies and testified at the Congressional Hearings. Frank led site visits to clinics being researched by OTA and the IAT Clinic was reopened.

In 1986, Frank and his wife Denise founded People Against Cancer and organized The International Coalition for the Evaluation of Alternative Cancer Therapies. It was largely through such efforts, including bitter struggles over three years that the OTA report was re-written and made into a useful document for Congress and the public. In conversations with thousands of people with cancer, health activists, as well as over 50 members of Congress; guest appearances on Design for Living, Natural Living, For the People, and other radio programs; prominently featured interviews in The New York Times, The Washington Post, The Des Moines Register, Scientific American, Science, East West, etc; and publications in the Journal of the American Medical Association and the International Association of Cancer Victors and Friends (IACVF) Journal, Frank has tirelessly fought for the fair testing of innovative, non toxic cancer therapies.

In 1993, Frank was a founding member of the Office of Alternative Medicine (OAM) in the National Institutes of Health (NIH). In 1994, Frank was chosen to be the Chairman of the Pharmacological and Biological Treatments Committee and chosen to serve a four-year term on the National Advisory Board of the Office of Alternative Medicine. Scientific American wrote, “The Establishment of the Office of Alternative Medicine (OAM) constitutes a victory for Frank Wiewel.”

Through People Against Cancer, Frank has created and administrates the Alternative Therapy Research Program (ATRP), a program to evaluate treatment options for people with cancer and physicians. Frank has also created and organized the International Physicians Network (IPN) to provide innovative treatment options for people with cancer. In 1996, Frank launched the Alternative Therapy Evaluation Program (ATEP) to conduct scientific evaluations, both retrospective and prospective, of innovative treatments for cancer worldwide.

Frank has been called “The most powerful independent voice in the field of cancer.” He is the editor of a critically acclaimed newsletter: Options: New Directions in the War on Cancer.  “The most revolutionary document published in the field of cancer – the truth, the whole truth and nothing but the truth.” Options remains the only independent newsletter in the field published without outside influence or advertisements.

Frank remains People Against Cancer’s founding executive and runs this grassroots organization from his base in Otho, Iowa (pop. 650), where he lives with his wife, Denise and their daughters Megan and Allison. More information is available at: http://www.peopleagainstcancer.org/

Enjoy the interview below:

 

Cannabis/Chris Conrad & Constance Finley

Sunday, May 14th, 2017

C Conrad

Chris Conrad (born March 10, 1953) is an American author, activist, curator, publisher and court-recognized expert in cannabis cultivation and use. He has played a key role in the shaping of the modern industrial and medical cannabis reform movements as the author of such seminal books as Hemp: Lifeline to the Future (1993) and Hemp for Health (1997), as well as through his activist work as the co-founder and first President of the Hemp Industries Association (HIA), founder of the Business Alliance in Commerce and Hemp (BACH), and the signature gathering coordinator for the Proposition 215 volunteer effort which made California the first US state to legalize the medical use of cannabis.[1] The December, 1999 issue of High Times ranked Conrad #10 on its list of top 25 “living legends in the battle for legal cannabi

Conrad’s writing career began when he designed and edited a revised edition of the hemp prohibition classic The Emperor Wears No Clothes by Jack Herer in 1990. He followed this with the publication of Hemp: Lifeline to the Future (1993), which was subsequently translated into Italian, and Hemp for Health (1997),[6] which was subsequently translated into Spanish Portuguese, Czech and German. He is also the author of Cannabis Yields and Dosages (2004) and Nostradamus and the Attack on New York.

Conrad has co-authored two books with collaborators Virginia Resner and his wife Mikki Norris: Shattered Lives: Portraits From America’s Drug War   and Human Rights and the US Drug War.

In 2007, Conrad contributed a chapter on cannabis history to Pourquoi & Comment Cultiver Du Chanvre by Michka,[12] where his writing appeared alongside contributions from other notable authors such as Jorge Cervantes, Raphael Mechoulam and Stephen Jay Gould.

In 1989, Conrad and his wife Mikki Norris co-founded the American Hemp Council, with the purpose of educating the American public on the many uses of industrial hemp and the laws against the crop in the United States.

In 1996, in the final weeks of the campaign (after the money came in and he was hired to do so), Conrad became the signature-gathering coordinator for the volunteer effort to pass California’s Proposition 215, the initiative which would go on to make the state the first in the US to legalize the medical use of marijuana.[14] He was also a vocal supporter of California’s Proposition 19 in 2010, which came within four points of making California the first state to legalize all adult uses of cannabis.[

Conrad has also been active in the movement to legalize industrial hemp, serving as the first president of the Hemp Industries Association (HIA) and founding the Business Alliance of Commerce in Hemp (BACH).

Since 2007, Conrad has taught at Oaksterdam University’s Oakland, California campus, where he teaches the history and politics of cannabis.

In 1993 and 2000, Conrad curated and designed the Hash-Marijuana-Hemp Museum in Amsterdam, The Netherlands. In 1995, Conrad and his wife Mikki Norris partnered with Virginia Resner to create and curate the “Human Rights ’95: Atrocities of the Drug War” photo exhibit to put a human face on non-violent prisoners of the Drug War and to show how the Drug War operates through their stories. Launched at the Fort Mason Center in San Francisco on June 24, 1995 for the 50th Anniversary the United Nations, the exhibit was put in context of the UN’s Declaration on Human Rights. The grand opening presented a program called, “Give Drug Peace a Chance,” that included Ram Dass, Paul Krassner, Jello Biafra, Ngaio Bealum, New Riders of the Purple Sage, and Terence Hallinan. They toured with this exhibit for many years, creating smaller excerpted displays that were shown at libraries, universities, conferences, and events under the name “Human Rights and the Drug War.” From 2011 to the present, Conrad has curated the Oaksterdam Cannabis Museum in Oakland, California.In 2014, Conrad and his wife Mikki Norris were jointly awarded the Seattle Hempfest Outstanding Cannabis Activist Award in recognition of their writing and advocacy work.

In 2010, Conrad was the recipient of Oaksterdam University’s Lifetime Achievement Award.

In 2004, Conrad and Norris received the Outstanding Citizen Activism Award at the 2004 national NORML conference.

In 2001, Conrad and Norris received the Drug Policy Alliance’s Robert C. Randall Award for Achievement in the Field of Citizen Action, along with collaborator Virginia Resner, Randy Credico of the William Moses Kunstler Fund for Racial Justice and Nora Callahan of the November Coalition.

The above information was taken from Wikipedia where Chris is listed.

ConstanceFinley

Constance Finley, founder and CEO of Constance Therapeutics, was inspired by her own personal experience with a chronic illness. After nearly dying from the pharmaceuticals prescribed to help alleviate pain and inflammation caused by a rare autoimmune disease, Finley turned to medical cannabis for relief.

She quickly became fascinated with the science behind the medicinal benefits of cannabis. Studies have found that cannabinoids, like THC and CBD, are more effective when working in tandem with the entire phytochemical profile of the female cannabis flower versus working in isolation – what is known as “The Entourage Effect.” Based on her research, Finley became determined to make standardized, whole plant cannabis extracts that incorporate all the naturally occurring cannabinoids, terpenes and flavonoids in cannabis, and are safe for those with compromised immune systems.

Prior to Constance Therapeutics, Finley was founder and CEO of Housing Allies, Inc. She pioneered the use of tax credits to create high-quality, aesthetically delightful low-income housing for the working poor and ill, utilizing corporate investments motivated by financial tax benefits. Finley also worked as a clinical psychologist and taught psychology courses at Naropa University, Greeley Junior College and Lone Mountain College. She holds a Master of Arts in Clinical Psychology from the University of San Francisco, where she graduated first in her class, and a Bachelor of Arts in Eastern Studies and Psychology from Lone Mountain College, where she graduated summa cum laude.