Posts Tagged ‘antihistamines’

Glioblastoma Research Shows Tumor Cell Death in Cell and Animal Studies Using Antihistamines.

Wednesday, July 17th, 2019

A new study published in EMBO Molecular Medicine Journal concluded that “antihistamines and other drugs that increase the permeability of the lysomal membrane can be considered as an enhancing therapy for patiets with glioblastoma alongside established treatments.” In the research they found that “glioblastoma cells depend upon the expression of a gene which produces the MDGI protein (small fatty acid binding protein). Inhibiting of this gene results in the death of the tumor cells.” The absence of MDGI causes instability in the membranes of lysosomes, cleaning organelles found inside tumor cells, and in turn, resulting in the leakage of acidic and proteolytic enzymes contained in the lysosomes into the cytoplasm, initiating cell death. Reasearchers said their research “demonstrates that MDGI  is a key factor regulating and maintaining the structure of the lysosomal membrane. This is the first gene found to regulate the stability of the membrane.”  Their results are especially interesting because they found that cell death caused by leakage in the lysosomes of glioblastoma can be activated by using drugs that cross the blood-brain barrier” and in this study they used the antihistamine clemastine.

In cell cultures the antihistamine in lysosome-initiated cell death in glioblastoma cells were at concentrations that has no significant effect on healthy cells of different types.  In mouse models it was effective in reducing the spread of brain tumors and improving the survival rates of the animals. In the most invasive brain tumor model, the antihistamine resulted in the disappearance of the entire tumor.

 

 

 

Natural Solutions for Seasonal Allergies Discussed by Dr Dobri Kiprov and Dr Ann Lovick on the Holistic Health Show

Sunday, July 25th, 2010

dobri

Ann Lovick Website

Dr Carl O Helvie, host, interviewed Dr Dobri Kiprov and Dr Ann Lovick on the Holistic Health Show yesterday. Both talked about natural solutions for seasonal allergies.

Dr Kiprov a physician and pioneer in the field of immunology is chief of immunology at California Pacific Medical Center in San Francisco. He is world renown for his work. More information is available on an earlier blog and at: www.lifestyleinmotion.com and www.dobrikiprov.com

Dr Lovick is a naturopathic physician who is on the staff of Integrative Health Care in Scottsdale, Arizona and has been a lifelong sufferer of allergies. More information is available on an earlier blog and also at: Http://integrativehealthcare.com/drlovick.htm

The interview follows: