Posts Tagged ‘apigenin’

Can Components in Celery Kill Lung Cancer Cells?

Wednesday, October 8th, 2014


A new study published in PubMed concluded that celery killed up to 86 percent of lung cancer cells in vitro. It has also been found effective in killing ovarian, pancreatic, prostate, breast. and liver cancer cells because of the anticancer compound called apigenin. Researchers found that by eating just two medium stalks of celery two or three times a week they could reduce the risk of lung cancer by 60%. However, researchers are not sure if results are due to the apigenin or if it works in coperation with other compounds found in celery. They also said “Apigenin widely inhibits cell proliferation of vartious lung cancer cell lines in a dose-dependent manner and the combination treatment of apigenin and antitumor drugsis very effective in human lung cancer cells, and Nrf2-ARE pathwaymay contribute to the mechanism.” In previous studies they found  “an inverse relationship between vegetable and fruit intake and lung cancer risk in both strata of current and never smokers.” Found also were women who ate plenty of apigenin in their diets were more likely to reduce the risk of developing breast cancer by 1%. and ovarian cancer by 20%. It is believed that apigenin may work by reducing the possibility of cancerous tumors growtrh by decreasing the vascular endothelial and decreasing the glucose uptake–minimizing the cycle of cancer cell formation in the pancreas. the researchers encourage everyone to eat celery but caution people to eat organic because celery is ofter drenched with pesticides.


Can Certain Flavonoids Kill Human Pancreatic Cancer Cells?

Friday, August 23rd, 2013

logo1267406_mdA new study published in Molecular Nutrition and Food Research concluded that celery, artichokes, and herbs, especially Mexican oregano, all contain apigenin and luteolin, flavonoids that kill human pancreatic cancer cells in the lab by inhibiting an important enzyme. They found that apigenin alone induced cell death in two aggressive pancreatic cancer cell lines but the best results were received when the cancer cells were pretreated for 24 hours with apigenin and then applied chemotherapeutic drug gemcitabine for 36 hours.

Thus, using the flavonoids as a pre-treatment instead of applying it simultaneously with the chemotherapy drug worked best. The author said “Even though the topic is still controversial, our study indicates that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs.” “That happens because flavonoids can act as antioxidants. One of the ways that chemotherapeutic drugs kill cells is based upon their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they are introduced at the same time.”

Researchers found that apigenin inhibits an enzyme called glycogen synthase kinase-3β (GSK-3β) that led to a decrease in the production of anti-apoptotic genes (self-destructing) in the pancreatic cancer cells. The percentage of cells undergoing apoptosis went from 8.4 percent in cells that had not been treated with the flavonoids to 43,8 percent in cells that had been treated with 50-micromolar dose. In this case, no chemotherapy drug had been added.  Treatment with the flavonoids also modified gene expression especially those associated with pro-inflammatory cytokines.

Can Vegetables Effective Treat Breast Cancer?

Friday, June 1st, 2012

A new study published online in Hormones and Cancer concluded that apigenin, extracted from celery, parsley and many other natural sources, is effective against human breast cancer cells that had been influenced by a certain chemical, progestin, used in hormone replacement therapy.

In the study, researchers implanted cells of a deadly, fast growing human breast cancer, known as BT-474, into a  specialized breed of mouse. Some of the mice were treated with medroxyprogesterone acetate (MPA), a type of progestin, often given to post-menopausal women. A second group, the controls, did not receive the MPA.  Later one group of the MPA treated mice were treated with apigenin and another was not. Cancerous tumors grew rapidly in mice not receiving apigenin. However, in the group receiving apigenin, cancer cell growth dropped to the level of the control group and their tumors shrank. It was determined that apigenin slowed the progression of breast cancer cells in three ways: 1)Inducing cell death; 2) Inhibiting cell proliferation; and 3) Reducing the expression  of a gene associated with cancer growth. Researchers said “Apigenin has shown no toxic side-effects even at high doses.”  More research is planned.