Posts Tagged ‘aspirin’

Can NSAIDs Lower Breast Cancer Recurrence in Overweight, Obese Women

Wednesday, August 20th, 2014

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A new study published in Cancer Research concluded that the recurrence of hormone related breast cancer was cut in half in overweight and obese women who regularly used aspirin or other non steroidal anti-inflammatory drugs (NSAID’s). authors said “Our study suggests that limiting inflammatory signaling may be effective, less toxic approach to altering the cancer promiting effects of obesity and improving patient response to hormonal therapy.”  In their study researchers fround that women  whose body mass index was greater than 30 and had estrogen receptor alpha (ERa) -positive breast cancer had a 52 percent lower rate of occurrence and a 28-month delay in time of recurrence if they were taking aspirin or other NSAID’s. Using blood from obese patients, researchers carried out laboratory experiments to recreate atumor environment containing cancer cells, fat cells, and the immune cells that promote inflammation. They found that factors associated with obesity initiate a network of signaling within the tumor environment to promote growth and resistance to therapy. They concluded “These studies show that the greatest benefit from aspirin and other NSAID’s will be in those with a disease driven by inflammation , and not just obesity.”

Datwa was used from 440 women diagnosed with invasive ERa-positive breast cancer and treatedbetween 1987 and 2011. Of the group studies 48.5 percent were obese and 25,8 percent were overweight. About 81 percent took aspirin, and the rest took another NSAID.  About 42 percent and 25 percent took statins and omega-3 fatty acid respectively. After controlling for statin and omega-3 fatty acids that have anti-inflammatory effects, there was still an indication of protection from aspirin and other NSAID’s.

Can Lifestyle Factors Reduce the Risk of Esophageal Cancer?

Friday, April 12th, 2013

logo1267406_mdRecent news from the Seattle Barrett’s Esophagus Program  at the Fred Hutchinson Cancer Research Center in collaboration with Brigham & Women’s College and the University of California in San Francisco have shown that a systematic approach to early  cancer detection can boost five-year survival rates from about 15 percent to more than 80 percent. They  have also shown that modifiable lifestyle factors-from reducing obesity to quitting smoking–may also prevent progression of Barrett’s esophagus to esophageal cancer. Some of the ways to prevent this condition from progressing to esophageal cancer were identified and follow.

Earlier research in 2007 reported that people with the more aggressive form of Barrett’s may benefit gfrom preventive therapy with aspirin or other non steroidal anti-inflammatory drugs. Following Barrett’s patients over time they identified a cluster of 4 known cancer bio markers  in this group that increased their risk of developing esophageal cancer. They found that subjects with 3 or more of these bio markers who also used aspirin or other no0nsteroidal anti inflammatory drugs (NSAID’s)  had a 30 % chance of developing esophageal cancer after 10 years whereas those who did not use the aspirin had a 79% change of developing cancer with a decade. They believe aspirin and other non-steroidal inflammatory drugs may fight cancer by reducing chronic  inflammation. However, because this was a long term observational study and not a clinical trial they cannot recommend aspirin for people with Barrett’s and also advise that anyone wh uses them do so under medical direction because of the side effects such as g.i. bleeding.

Another study looked at Barrett’s and statin drugs for lowering cholesterol and found that various combinations of statin and/or NSAID’s used by patients with Barrett’s and and high grade dysplasia had a reduced risk of esophageal cancer when compared with those who did not use these drugs.

This year they lo0ked at lifestyle and esophageal cancer and found that heavy smokers with Barrett’s were more than twice as likely to develop esophageal cancer than non-smokers with Barrett’s. They also found that obesity especially belly fat, was more strongly associated with the progression of Barrett’s to esophageal cancer.

They also offered suggestions for managing the symptoms of chronic acid reflux that is a risk factor for Barrett’s. These included smoking cessation, keeping weight down, getting regular exercise, eating a diet rich in fruit and vegetables, refrain from eating four hours before retiring, elevate the head of your bed if you have heart burn, and take antacids for occasional heartburn and see you doctor if you have frequent heartburn or if over the counter medications do not help.

Pancreatic Cancer Risk Lowered with Aspirin Use

Wednesday, April 20th, 2011

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A study presented at the American Association of Cancer Research in Florida from April 2 to 6, concluded that there was a significant reduction in pancreatic cancer risk for those individuals using aspirin at least once a month. Although this was a large collaborative study the results are preliminary according to the researcher and widespread use of aspirin without medical consultation is discouraged.
In the study 904 patients with documented pancreatic cancer were compared with 1,224 healthy patients. All were at least 55 years of age and reported their use of aspirin, NSAIDs and acetaminophen by questionaire. Results showed that those who took aspirin at least monthly had a 26% reduced risk of pancreatic cancer compared to those who did not take regular aspirin. The results were also seen for those who took low dose aspirin for heart disease prevention at a 35% reduction. However, no benefits were seen for using non-aspirin NSAIDs or acetaqminophen.

More information is available at:
http://webcache.googleusercontent.com/search?q=cache:3mKguKWia2YJ:www.nlm.nih.gov/medlineplus/new

Painkillers May Decrease Hormone Levels That In Turn May Reduce Breast and Ovarian Cancers

Wednesday, March 31st, 2010

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Research published in the recent issue of Cancer Epidemiology, Biomarkers & Prevention concluded that postmenopausal women regularly using aspirin and other painkillers have lower estrogen levels than those not using these products and that may contribute to a decreased risk of breast or ovarian cancer.

Seven hundred forty postmenopausal women who participated in the Nurse’s Health Study were examined for an association between the use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen and concentrations of estrogens and androgens. Findings showed an inverse relationship between the frequency of painkiller use and estradiol, free estradiol, estrone sulfate and the ration of estradiol to testosterone.

Average estradiol levels were 10.5% lower among women regularly using aspirin or NSAIDs. In addition this group also showed 10.6% lower free estradiol levels, and 11.1% lower estrone sulfate levels. In addition, among regular users of any painkiller (aspirin, NSAIDs, or acetaminophen) the levels of these hormones were 15.2% lower (estradiol), 12.9% lower (free estradiol), and 12.6% lower (estrone sulfate).

Michael Thun, M.D. Vice-President Emeritus of epidemiology and surveillance research at the American Cancer Society said that the association of painkillers use and breast cancer risk is important but still unresolved. He further said that the results do not confirm a relationship between painkillers and lower circulating levels of estradiol but it is promising and further research is needed.

Aspirin May Reduce Deaths after Treatment for Breast Cancer

Friday, February 26th, 2010

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A study in the Journal of Clinical Oncology reported that “aspirin can significantly reduce the risk of cancer spread and death in women who have been treated for early breast cancer.” Researchers at Harvard Medical School studied 4,164 female registered nurses taking part in the Nurses’ Health Study. Starting in 1976 they looked at who took aspirin, who developed breast cancer and all causes of death up until 2006. During this time 341 nurses died of breast cancer. Of this group women who took aspirin two to five days a week had a 60% reduced risk of their cancer spreading and a 71% lower risk of breast cancer death. Other non-steroidal inflammatory drugs (NSAID’s) in the same class as aspirin had the same effect and included ibuprofen and naproxen but not acetaminophen. This relationship was not as clear because of limited data. Although aspirin is relatively benign compared with chemotherapy drugs it can cause bleeding and should not be taken without medical supervision. It also should not be taken while undergoing chemotherapy or radiation therapy because of the possible side effects.

Dr Garrett Smith, N.P., and Karon White-Gibson Interviewed on the Holistic Health Show

Sunday, November 29th, 2009

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Dr Carl O Helvie, Host of the Holistic Health Show, interviewed Dr Garrett Smith and Karon White-Gibson on arthritis last night. Dr Smith, a naturopathic physician in Tucson, Arizona, talked about the effect of nightshades on arthritis. His biography was published earlier on this site.
Mrs Karon White-Gibson is a registered nurse, author and television host who has arthritis. She talked about the natural treatments she has used. Her biography was published on the site earlier.
You can listen to the interview below. I hope you will enjoy it.

An Aspirin a Day and Weightlifting May Keep the Cancer Away

Friday, August 21st, 2009

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A study reported this month concluded that a daily dose of aspirin decreases the risk of death from colon cancer. Although it has been know that aspirin reduces the risk of developing colon cancer this study that needs to be replicated found that the risk of death in those with colon cancer is reduced by daily aspirin. The study reported in the Journal of the American Medical Assn reviewed 1,279 cases of men and women with colon cancer without metastasis and at different stages from 1980 to 2008. One of the two groups took a regular dose of aspirin (325mg) at least twice a week for a total dose of 650 mg or more for a week. Those with colon cancer and on the aspirin dose were 29% less likely to die of colorectal cancer and 21% less likely to die overall. More information is available at:
http://jama.ama-assn.org/cgi/content/abstract/320/6/649

A second study looked at weight lifting and breast cancer. In the past women treated for breast cancer were warned not to lift heavy items such as babies and groceries to avoid chronic arm swelling (lymphedema). Results of a new study from the University of Pennsylvania reverses this advice. In the study, women who lifted weights twice a week for a year after breast cancer had fewer debilitating symptoms and flare-ups and some of the 70 women were able to completely control the fluid buildup. This study was the the largest and most rigorous to show the benefits without risks of slow, progressive, strength training for women with breast-cancer related lymphedema. More information is available in: Schmitz, K, Ahmed, R, Troxel, A. et al (2009)
Weight Lifting in Women with Breast-Cancer-Related Lymphedema, NEJM, Vol 361, No 7, August 13, 664-672.