Posts Tagged ‘biopsies’

New Less-Invasive Method for Detecting and Monitoring Prostate Cancer

Wednesday, October 3rd, 2012

A recent study published in the online Journal of Urology concluded that contrast-enhanced ultrasound was better at detecting high grade prostate cancer than conventional methods making it more appropriate for screening and monitoring with less biopsies. The randomized, double bind study used microbubbles to measure changes in blood flow and found almost three times as many higher grade cancers using half as many needle biopsies compared to systemic biopsy methods. The lead researcher said “Today, a physician may sample 12 to 18 tissue cores from the prostate in order to help diagnose a patient.  But with contrast-enhanced, that number drops to six or even less.”  “So it’s less invasive, and a more effective tool.”

In the clinical trial of 311 men, 118 had positive prostate cancer biopsies revealing that targeted biopsies using contrast-enhanced ultrasound witrh microbubbles detected significantly more  higher voolume/grade prostate cancers (clinically significant) in men (55 percent) compared toi a conventiuonal prostate buiopsy technique (17 percent). All subjects received targeted biopsies using contrast-enhanced ultrasound with flash replenishment maximum intensity projection MicroFlow Imaging and a systemic 12-core biopsy protocol for comparison. The mean age of suvjects was 62 years and a PSA of 6.5ng/ml.

Less Invasive Diagnostic Test For Lung Cancer Being Studied

Friday, May 27th, 2011


Research presented at the American Thoracic Society (ATS) 2011 International Conference concluded that a minimally invasive test using cells from the interior of the nose might be useful in detecting lung cancer at an early stage. The earlier studies used gene expression difference in cells in the bronchial airway to identify lung cancer in the early stages. Using this model the researchers developed a hypothesis that “the upper airway epithelium of smokers with lung cancer displays a cancer-specific gene expression pattern, and that this airway gene expression signature reflects the changes that occur in lung tissue.”
Nasal epithelial cells were collected from 33 smokers who were undergoing medically-indicated bronchoscopies for suspected lung cancer. From this group 11 had benign disease, and 22 had lung cancer. Brushing were taken from the left and right nostril and profiled on microarrays, a process for studying gene expression change, to determine genes that differed in their expression between those with lung cancer and those with benign disease. One hundred seventy genes were discovered that differentially expressed between the two groups of patients. The researchers stated that results show an initial indication that simple nasal brushings could offer an alternative to lung biopsies or other invasive techniques used currently to diagnose lung cancer. A large study to validate the results from this pilot study is planned.