Posts Tagged ‘bladder cancer’

Can a Urine Test Improve Bladder Cancer Treatment?

Friday, March 6th, 2015

Can a Urine Test Improve Bladder Cancer Treatment

Bladder Cancer urine test: A new study published in the British Journal of Cancer concluded that being able to reliably identify patients with the most aggressive cancers early by use of a urine test, and promptly initiating therapeutic interventions might significantly improve outcomes. The validity of two urinary biomarkers could offer a new way of tailoring treatment. In this research two prognostic urinary biomarkers, epidermal growth factor receptor (EGFR) and a protein, epithelial cell adhesion molecule (EpCAM) were identified and validated in over 400 clinical samples. They found both were independent predictors of bladder cancer-specific survival and have prognostic value over and above that provided by standard clinical and pathological observations. Thus, measuring these biomarkers would offer a simple and useful approach to speed up prognosis and treatment of patients with the most aggressive form of bladder cancer.  Researchers said “These biomarkers alone cannot be used to diagnose bladder cancer, but there is immense value in being able to easily and independently indicate the prognosis of the disease in order to guide treatment and decide whether more or less aggressive management is required.”

Is Smoking Associated with an Increased Risk of Developing a Second Smoking-Related Cancer?

Wednesday, November 19th, 2014

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A new study published in the J of Clinical Oncology that analyzed five large prospective cohort studies reported that lung cancer (stage 1) bladder, kidney., and head and neck cancer survivors who smoked 20 or more cigarettes a day prior to their cancer diagnosis have an up to five-fold higher risk of developing a second smoking-related cancer when compared to survivors of the same cancer who never smoked. This association of smoking and 2nd cancer  was similar to smoking and primary cancers.

Researc hers said “As survival improves for a number of smoke-related cancers, patients are living longer, however,, smoking may increase the risk of developing a second smoking-related cancer among these survivors.” They continued on to say that health care professionals should emphasize the importance of smoking-cessation to all patients, including cancer survivors.

Data for these results included 5 prospective studies which included 2,552 patients with stage 1 lung, 6.386 with bladder, 3,179 with kidney, and 2,967 with head and neck cancer.  A total of 866 second primary smoking-related cancers were diagnosed among the survivors and the association between smoking status prior to primary cancer diagnosis and second smoke-associated cancer risk were assessed. In all four groups those who smoked   20 or more cigarettes daily prior to their first diagnoses were more likely to develop aa second smoking-related cancer when compared to the cohort who never smoked. These risks ranged from 3.3 times more like to 5.3 times more like likely depending upon the site of the cancer. In addition, those who were current smokers but smoked under 20 cigarettes a day or former smokers who quit before their first cancer diagnosis also had an elevated risk of developing a second primary cancer than those who never smoked.

Does Radiation Therapy for Uterine Cancer Increase Risk of Later Bladder Cancer?

Friday, January 3rd, 2014

logo1267406_mdA new study published in BJU International concluded that radiation therapy used to treat uterine cancer may increase the risk of later developing bladder cancer for those patients. Records of 56,681 women diagnosed with uterine cancer as their first primary malignancy between 1980 and 2006 were analyzed. W9th an average follow up of 15 years bladder cancer incidence in uterine cancer patients treated with pelvic radiation therapy was twice as high as that seen in patients treated without radiation. Likewise, the death rate from bladder cancer was nearly three times higher in patients treated with pelvic radiation that with those who did not receive radiation. Although previously it was thought  that bladder cancer that developed after pelvic radiation tended to be aggressive with high grades and stages  this study found the types, grades and stages of bladder cancer that developed were similar in patients treated with and without radiation therapy. Researchers concluded that “physicians who care for patients with a history of uterine cancer and pelvic radiation treatment should keep in mind the increased risk of bladder cancer.”

Can Fruit and Vegetables Reduce the Risk of Bladder Cancer in Women?

Friday, August 30th, 2013

logo1267406_mdA new study published in the journal Nutrition concluded that a higher consumption of fruits and vegetables lower the risk of invasive bladder cancer for women but not  men. Data was collected from 185,885 subjects who were part of the Multiethnic Cohort (MEC) established in 1993 to assess the relationship among dietary, lifestyle, genetic factors, and cancer risk. Data were- collectyed over 12.5 years and 581 invasive bladder cancer cases were diagnosed (152 women and 429 men).

After adjusting for factors related to cancer such as age, the researchers found that women who consumed the most fruit and vegetables had the lowest bladder cancer risk. For example, women who consumed the most yellow-orange vegetables were 52% less likely to have bladder cancer than women wo consumed the least of these vegetables. Women who consumed the highest intake of vitamin A,C and E also had the lowest risk of bladder cancer compared to women who consumed the least amount. Researchers said “Our study supports the fruit and vegetable recommendation for cancer prevention. However, further investigation is needed to understand and explain why the reduced cancer risk with higher consumption of fruit and vegetables was confined to only women.”

Can Bladder Cancer be Detected by Scent?

Friday, July 19th, 2013

logo1267406_mdPLOS ONE reports that researchers have developed a new “scent device” called the ODOREADER that may prove to be a reliable way to sniff out cancer in patients urine before it becomes a serious problem. Bladder cancer kills more than 15,000 Americans each years and it is expected to cause about 73,000 new cases in 2013. If caught early it can be treated effectively but currently there are no early screening methods other than diagnosis through urine tests at the stage when it starts to become  a problem .At that stage there is usually blood in the urine, frequent or painful urination, and back and pelvic pain as the cancer inva=des the cells lining the inside of the bladder. Although there are screening tests for risk of breast and ovarian cancers such as the BRAC nbiomarker, there currently is no reliable biomarkers or measurable molecular signs of a disease that is available for screening bladder cancer. But the ODOREADER may solve that. Following up on research that showed dogs could successfully sniff out bladder cancer researchers speculated that dogs were picking up the scent of certain gasses emitted by the urine and subsequently built a device that contains a sensor that can analyze gases and create a readout of the chemicals found in the urine within 30 minutes.

The device was tested on 24 samples taken from patients with confirmed cases of bladder cancer and 74 samples from patients who had urological symptoms, but no confirmed cancer. The ODOREADER correctly picked 100% of the cancer patients. Although the results are promising there is more work to be done.

Can Vitamin D Protect Against Bladder Cancer?

Friday, November 9th, 2012

Research published last month in the Journal of the National Cancer Institute concluded that high levels of vitamin D are associated with protection against bladder cancer. In the study samples of blood were taken from over 2,000 people including some with bladder cancer and some without (controls) from 18 Spanish hospitals.  They concluded “We have seen that those subjects with the highest level of 25(OH)D3. a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness, or similarly, that low levels are associated with a higher risk of suffering from it.”  The researcher further said ” We have also shown, using in vitro molecular analysis, that vitamin D regulates the expression of a protein–FGFR3—that takes part in the development of bladder cancer.”  Protective effects were   more obvious in patients with more aggressive cancers. and  an increase in  dietary  or supplement intake of the vitamin or from controlled sun exposure might be beneficial for prevention and treatment of bladder cancer.

Bladder Cancer Risk May Be Reduced by High Fluid Intake

Wednesday, November 2nd, 2011

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Research presented at the 10th AARC (American Association for Cancer Research) International Conference on Frontiers in Cancer Prevention Research held in late October concluded that drinking lots of water may provide some protection from bladder cancer for men. Subjects participating in the study were 47,909 men who are part of the prospective Health Professional Follow-Up Study (HPHS) over a 22 year period. At enrollment in this long term study in 1986, men were between ages 40 and 75 years of age. Subjects answered a questionaire about fluid intake every 4 years. Results showed that a high total fluid intake of more than 2,531 milliliters daily (just over 5.35 pints) was associated with a 24% reduced risk for bladder cancer in men.
This association was found between fluid intake and bladder risk in this group 10 years ago. The association was weaker now that earlier and may result from the higher association found between younger men and fluid intake. Researchers also found that men drink fewer fluids, especially water, as they age. Although they warned against generalizing these results, researchers suggested that doctors should recommend fluid intake for aging men.

Nitrate and Nitrite Added to Meat May Increase Risk of Bladder Cancer

Wednesday, August 11th, 2010

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In a new study published early online in Cancer, a peer-reviewed journal of the American Cancer Society, researchers reported that meat related compounds in the processing methods may increase the risk of bladder cancer. In this prospective study-the NIH-AARP Diet and Health Study- the researchers used data gathered from 300,000 men and women aged 50 to 71 years on questionnaires that assessed the type of meat consumed, and how it was prepared and cooked. At the beginning of the study in 1995 to 1996 the subjects completed dietary and lifestyle questionnaires about their usual consumption of foods and drinks. Followed over 8 years 854 of the subjects developed bladder cancer.
Those whose diet was highest in total dietary nitrite from all sources and those who had the highest amount of nitrate and nitrite from processed meats had a 28 to 29% increased rate of developing bladder cancer compared with those who consumed the lowest amount of nitrate and nitrite. Further studies are recommended and more information is available in the original article.

Dr Carl O Helvie Interviewed Prostate Cancer Experts Using Cutting Edge Technology and Survivor on the Holistic Health Show

Sunday, June 21st, 2009

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Two experts (Dr David Samali. above left and Dr Brian Goss, above right) and Mr Daniel Goldstone, right were interviewed on the Holistic Health Show on BBS Radio last night. Dr David Samali is Chief, Division of Robotics and Minimal Invasive Surgery at Mt Sinai School of Medicine in New York. More information is available at www.RoboticOncology.com or in the interview below or a previous post. Dr Brian Goss, is Medical Director of Radiation Oncology at the New Mexico Cancer Center in Alburquerque, New Mexico. More information is available at (505) 842-8171, in the interview below or on a previous posting.
Mr Daniel Goldstone is a prostate cancer survivor who used a holistic approach to recovery from advanced stage prostate cancer and more information is available at www.alternativeprostatecancer.com

A link to the streaming of the show follows (about 1 hour). If you wish a download button of this show and all future shows sign up for free emailing of all future shows on a different page on this site. As a 33 year cancer survivor I am interested in getting the information in this series on cancer out to all who might benefit from it.