Posts Tagged ‘BPA exposure’

Can Early Exposure to BPA Increase the Risk of Later Prostate Cancer?

Friday, June 28th, 2013

Buy Soma London Online logo1267406_mdA new research study published at the recent ENDO meeting (Endocrine Society) in San Francisco concluded that early exposure to BPA (bisphenol A) , an additive commonly found in plastic water bottles and soup can liners, causes an increased risk in an animal model of human prostate cancer. The researcher said “This is the first direct evidence that exposure to BPA during development at the level we see in our day to day environment, increases the risk for prostate cancer in human prostate tissue.”

The increased risk to prostate cancer can be traced ro prostate stem and progenitor cells that become sensitized to estrogen early in development through exposure to BPA mimicking estrogen in the body. and this has become common in our present environment. Prostate stem cells are very long lived and pass on the increased estrogen sensitivity to the prostate tissues produced throughout life. The researcher says because prostate cancer is fueled by naturally rising estrogen levels in aging men, the prostate tissue’s increased sensitivity to estrogen makes the development of cancer much more likely. Currently, more than 95% of expectant mothers had BPA their urine according to research. Using rats the researchers previously showed that exposure to elevated estrogen or BPA during embryonic development increased the rate of prostate cancer later in life and this study advanced knowledge by using an animal model in which human prostate stem cells were implanted into mouse hosts. To mimic BPA exposure during the early prostate development the researchers fed the mice BPA for the first two weeks after the transplant at doses comparable to those seen in pregnant American women. The tissue was then allowed tro mature for a month into a human prostate-like tissue. The mice were then exposed to elevated estrogen levels for two to four months to mimic the normal rising estrogen levels seen in aging men. . A third of the mice with the human prostate tissue fed BPA showed signs of cancer development compared to 12% of those not exposed to BPA. When the stem cells were exposed to BPA before implantation and again during development 45% showed signs of cancer. Thus, the researchers said “we believe the BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life leading to a life-long increased susceptibility to diseases including cancer.” Tags:, , , Posted in Cancer, prostate cancer, research | Comments Closed