Posts Tagged ‘calorie restriction’

Longevity/Fasting/Stem Cells and Dr Valter Longo, the Guru of Longevity

Sunday, July 15th, 2018

Professor Valter Longo is internationally recognized as a leader in the field of ageing studies and related diseases. His discoveries include some of the major genetic pathways that regulate aging and life-threatening diseases and the identification of a genetic mutation that protects men from several common diseases.

He is a Professor of Gerontology and Biological Science and Director of the Longevity Institution at the School of Gerontology at the University of Southern California in Los Angeles, one of the leading centers devoted to teaching and research on ageing. He is also director of the Oncology Laboratory and longevity at the Institute of Molecular Oncology IFOM in Milan.

Professor Longo received the Nathan Shock Lecture Award from the National Institute on Ageing (NIA/NIH) in 2010 and in 2013 the Vincent Cristofalo ‘Rising Star’ Award for Research on Ageing, and the 2016 Glenn Award for research in the Biology of Aging.

In 2015, after a number of his papers were among the most widely cited in the biomedical field, Time magazine called him a ‘guru of longevity’.

Doctor Longo received a PhD from North Texas in 1992, and another one from UCLA in 1997 and completed post doctoral training in 2000. He has carried out research in the areas of fasting and longevity, cell biology and genetics, the regulation of aging and multiple  stress resistance systems in yeast and mammals, cancer, diabetes and Alzheimer’s.  He has over 70 peer reviewed articles, 4 books/chapters, multiple research grants, active grant reviewer, and student research advisor. He is author of the best seller The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight

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Enjoy the Interview Below:


Is Calorie Restriction Useful to Muscles?

Friday, May 1st, 2015

Is Calorie Restriction Useful to Muscles

Calorie restriction has the most benefit for aging muscles and may have a protective effects on muscle cells and may also help cells better use antioxidants, avoid damage caused by free radicals and  function better, according to a new study published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.

In their study researchers focused on two pathways that produce energy in muscles, glycolysis (sugar metabolism) and mitrochondrial oxidative phosphorylation (OXPHOS) in young and middle age rats that were fed either calorie restriction or a normal diet. In the 14 week study, rats on the calorie-restricted diet received 10 percent restriction in the first week, 25 percent restriction in the second and 40 percent restriction in the last 12 weeks. Control rats received no calorie restriction.  At the end of the 14 weeks changes in the rats muscles were studied.  “We investigates whether  CR (calorie restriction) reprogrammed muscle metabolism and whether this improvement was associated with the observed increase in muscle mass. In addition, we examined whether the CR-induced changes were age-dependent.”

The middle-aged rats had less muscle mass than the young rats. While 14 weeks of calorie restrictioin did not significantly affect the muscle mass of middle-aged rats, it reduced muscle mass in the young rats. It also slowed the glycolytic rate in the muscles and increased the cells’ dependency for OXPHOS versus glycolysis in older rats, which were linked to improvement of normalized muscle mass. Researchers also found that after 14 weeks of calorie restriction there was reprogrammed cellular metabolism, where the relative contribution of OXPHOS and glycolysis in muscles of middle aged rats with calorie restriction was similar to that in muscles of young rats.