Posts Tagged ‘causation’

How Does Cancer Develop?

Friday, September 2nd, 2016


A new study reported in Cell  concluded that a variety of conditions are needed by cells to start forming cancer and this process helps to explain why some organs are more susceptible than others to developing disease. The research showed that cancers are more likely to start in stem cells or special cells that copy themselves so the body can grow new cells, repair damaged tissues, and replace old cells. But while stem cells more readily develop into cancer  cells they need to have accumulated DNA mistakes and be replicating to repair damage or wear and tear for cancer to start. The DNA mistakes can happen randomly as stem cells replicate and tend to buildup with age making cancer more common among the aged. Environmental factors such as tobacco smoke and UV radiation can also cause DNA mistakes.

Using a fluorescent dye to track the behavior of a particular group of cells in mice the researchers hoped to find out how cancer starts in different organs. DNA mistakes linked to different types of cancer were then introduced into the group of cells. They found that DNA mistakes by themselves were not enough to cause cancer. In organs where DNA mistakes were introduced into dormant stem cells,there was no signs of cancer. However, in other organs that were exposed to lots of wear and tear such as the bowel, introducing DNA mistakes into the replicating stem cells caused cancer to start. They continued “We can now say that cancer most likely starts in stem cells but is not just down to “bad luck.” The development of cancer involves a ‘Perfect storm’ of stem cells containing DNA mistakes that are replicating in response to damage or wear and tear.”  “Although stem cells can sometimes go wrong by chance, our research shows that things in our environment that lead to more DNA mistakes or that damage organs, causing these stem cells to divide, increases the chances of the “perfect storm” brewing. That’s why behaviors like smoking or UV exposure raises the risk of developing cancer.” “Our work also shows why some tyes of cancer are more common than others with tumors more likely to develop in organs with lots of replicating stem cells, for example the bowels.”

Dr Mark Brown, Dr Phillip Cheras and Dr Eugene Lipov Interviewed on the Holistic Health Show

Sunday, April 18th, 2010

Dr  Mark Brown

P Cheras


Dr Carl O. Helvie, Host, Holistic Health Show interviewed Dr Mark Brown (top left), Dr Phillip Cheras (top right), and Dr Eugene Lipov (bottom left) yesterday. Dr Brown M.D., PhD is Professor and Chairman Emeritus of the Department of Orthopaedics and Rehabilitation at the University of Miami Miller School of Medicine and has over 40 years experience caring for patients with neck and back pain. His award winning book is titled “Conquer Back and Neck Pain: Walk it Off.“More information is available on a previous entry on this site and at

Dr Cheras, PhD, is the Deputy Director of the Australian Center for Complementary Medical Education and Research and has been principle or co-investigator of clinical trials in Complementary Medicine in excess of 5 million dollar. His doctoral research on osteoarthritis received international attention. More information can be found on an earlier blog here. He can be reached through his publicist at:

Dr Lipov, M.D., a board certified anesthesiologist and pain manager, is Director of Research at Northwest Community Hospital and Medical Director of the Advanced Pain Center. More information was presented on an earlier blog or he can be reached through his publicist at:

The interview from yesterdays show follows.