Posts Tagged ‘CVD’

Can Vitamin D Reduce Your Risk for Cancer and Many Other Diseases?

Wednesday, March 27th, 2013

logo1267406_mdA new study published online in PLOS ONE  concluded that improving vitamin D status by increasing the level in the blood could have a number of non-skeletal health benefits including cancer, cardiovascular disease, infectious diseases and autoimmune diseases reduction by impacting genes involved in a number of biological pathways associated with these conditions., The study shows that improvement in vitamin D status plays a large role in improving immunity and lowering the risk for many diseases.

The study involved a randomized, double blind, single-site pilot trial of eight healthy men and women with an average age of 27 who were deficient of vitamin D at the start of the trial.  Three subjects received 400 IU’s of vitamin D  daily and five received 2,000 IU’s  daily for 2 months. Samples of white blood cells (immune cells) were collected at the beginning and end of the two month period. Samples were subjected to a broad gene expression analysis and more than 22,500 genes were investigated to determine whether or not their activity  increased or decreased as a result of the vitamin D intake.

At the end of the trial, the group that received 2,m000 IUs achieved a vitamin D status of 34ng/ ml, that is considered sufficient, whereas the group receiving 400 IU daily received 25ng/mg that is considered insufficient. Results of the gene expression analysis indicated statistically significant alterations in the activity of 291 genes and that the biological functions associated with these genes are related to 160 biological pathways linked to cancer, autoimmune diseases, infectious diseases and CVDs. The researchers concluded that the study “reveals the molecular fingerprints that help explain the non-skeletal health benefits of vitamin D.” They further said “While a larger  study is necessary to confirm our observations, the data demonstrates that imp[roving vitamin D status can have a dramatic effect on gene expression in our immune cells and may help explain the role of vitamin D in reducing the risk of CVDs, cancer and other diseases.”