Posts Tagged ‘folic acid’

Do Dietary Supplements Increas Cancer Risk?

Wednesday, May 23rd, 2012

A report in the Journal of the National Cancer Institute concluded that three supplements–beta-carotene, selenium, and folic acid–taken at up to three times their recommended daily allowances, are probably harmless but at much higher levels have been shown to increase the risk of developing a variety of cancers. Unfortunately, although Professor Byers from Colorado School of Public Health presented general terms about the subject and the report was picked up by several news sources, there was no data to back up the conclusion in this commentary piece. Thus, until I see some research that documents the conclusions presented I would tuck it in the back of my mind without accepting untilĀ  I see validation of these conclusions by research.

Folic Acid and Colon Cancer

Friday, June 3rd, 2011

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A new study reported in Gut an international gastroenterology journal, concluded that the rate of colon cancer was reduced by 64% in the offspring of pregnant and breast-feeding rats fed folic acid supplements. Pregnant and lactating rats were placed on a control or supplemental diet (2.5 times the folic acid of the controls) prior to mating, and during pregnancy and lactation. At weaning, males from each maternal diet group were randomly assigned to a control or supplemental diet group (55 in each of the 4 groups) for 31 weeks Colorectal cancer was induced by azoxymethane at 5 weeks of age.
Results showed that maternal but not post weaning supplementation of folic acid significantly reduced the risk of colorectal adenocarcinoma by 64% in the offspring. The offspring from mothers in the control group who were subsequently fed supplemental folic acid had a higher tumor rate than the others. Thus, maternal supplementatioj of folic acid reduced the risk of tumors whereas post weaning supplementation did not.