Posts Tagged ‘fructose’

Is Type of Sugar Also A Risk Factor of Diseases?

Friday, March 10th, 2017


A new study published in The American Journal of Physiology –Heart and Circulatory Physiology concluded that the type of sugar youeat–and not just caloric count–may dtermine your risk of chronic disease. This animal study compared the effects of two types of sugar on metabolic and vascular function.

In the research female rats were given a liquid solution of glucose (form of sugar resulting from carbohydrate breakdown in the body) or fructose(sugar found in fruit and fruit juice) in addition to their normal diet of solid food. Subjects were given the sweetened liquids for eight weeks that is roughly equilavent to humans eating large amounts of sugar for six years. The sugar fed rats were compared with a control group that received plain drinking water with solid food.

Researchers found that although both sugar groups consumed more calories than the control group the total caloric intake of the glucose-fed rats was higher than the fructose group. In addition, “despite the difference, only the fructose group exhibited a significant increase in final body weight.” Besides a higher weight gain, the fructose group showed more markers of vascular disease and liver damage than the glusose group including high triglycerides, increased liver weight, decreased fat burning in the liver (that can contribute to fatty liver) and impaired relaxation of the aorta that can affect blood pressure.

Research suggest that an increase in the amount of calories consumed due to sweeteners is not the only factor involved in long-term health risks. The type of sugar may also have a role in increasing risk factors of heart diusease, diabetes, and other chronic diseases.

Fructose Associated with Growth of Pancreatic Cancer Cells

Friday, August 13th, 2010


In a study that appeared in the August 1 issue of Cancer Research, a peer-reviewed journal, researchers reported that pancreatic cancer cells use sugar fructose to activate a cellular pathway that drives cell division and helps the cancer cells grow more quickly. They stated “In this study, we show that cancer cells can use fructose just as readily as glucose to fuel their growth.”

The researchers used pancreatic cells from patients and cultured and grew them in petri dishes. Then they added glucose to one set of cells and fructose to another. They were able to determine what the sugars were being used for by following the carbon-labeled sugars in the cells using mass spectrometry. They found that even though the glucose and fructose sugars are similar in structure they were metabolized in very different ways. The pancreatic cancer cells used the fructose in the transketolase-driven non-oxidative pentose phoshate pathway to generate nucleic acids that are the building blocks of RNA and DNA needed by the cancer cells to divide and proliferate.

The researchers quoted an article that stated between 1970 and 1990 the consumption of fructose in the form of high fructose corn syrup (HFCS) increased over 1,000 percent in the United States. It is added to foods and beverages and is the sole sweetener used in American soft drinks. They believe there should be a federal effort to reduce the use of fructose in the United States.