Posts Tagged ‘genistein’

Can a Mushroom-Supplemented soybean Extract Extend the Lifespan of Men with Advanced Prostate Cancer?

Friday, March 1st, 2013

logo1267406_mdA new study published in Endocrine-Related Cancer concluded that a natural nontoxic product called genistein-combined polysaccharide (GCP) that is commercially available in most health food stores could help lengthen the life expectancy of men with certain prostate cancers. Men with prostate cancer that has spread to other parts of the body, who have their own testosterone lowered with drug therapy are most likely to benefit. Lowering of testosterone or androgen-deprivation therapy has been the standard of care for patients with metastatic prostate cancer but life expectancies vary for those using this treatment. This study shows promise for extending the lifespan of  those with low response to androgen-deprivation therapy.

GCP is a proprietary  extract cultured from soybeans and shiitake mushrooms and researchers found that a combination of the compounds genistein and daidzein,  both present in GCP helps block a key mechanism used by prostate cancer cells to survive in the face of testosterone deprivation. They showed that GCP keeps filamin A in the nuclear and as long as this protein remains attached to the androgen receptor, the cancerous cells need androgens to survive and grow.   They die off when starved of androgens, thus prolonging the effects of androgen deprivation, which ultimately prolongs the patients life.                                                                                                                                                                 The team’s hypothesis is that metastatic prostate cancer patients with the weakest response to androgen-deprivation therapy could be given GCP concurrently with androgen deprivation therapy to retain Filamin A in the nucleus, thereby allowing cancer cells to die off. Further research is planned with humans.

Melanoma-A Serious Skin Cancer

Wednesday, August 19th, 2009

picture-0611One of the guest interviewed this past week was a 33 year cancer survivor who had been given 3 months to live when diagnosed with melanoma. Melanoma is a serious form of skin cancer and usually can be avoided by reducing exposure to ultraviolet radiation from sunlight. When diagnosed in an early stage before metastasis it can often be successfully treated,

Traditionally surgery is used to remove cancerous tissue and in early stages may be all that is needed. Radiation and chemotherapy are not typically used except in advanced stages where there is metastasis.

There are some natural products that have shown promise when used for melanoma. Reducing sun exposure is crucial. A diet high in fruit and vegetables and whole grains is recommended. Studies have shown that vitamin D may suppress melanoma cell proliferation by up to 50% (good sources are dark green leafty vegetables and cold water fish) ; quercetin inhibits the invasiveness of melanoma cells in vivo; vitamin C and essential fatty acids inhibit the growth of melanoma cells in culture; mistletoe suppresses melanoma cell growth in vivo; genistein in soy products (legumes and soy beans) inhibits the growth of melanoma cells as effectively as chermotherapy drugs adriamycin and etoposide. The National Cancer Institute researchers also reported some success using a vaccine.

Research this month reported that starting to use of the tanning bed before age 30 increases the risk of melanoma by 75%. This same report stated that all types of ionizing radiation are carcinogens to humans and include: radon gas in homes cause lung cancer, plutonium and decaying products, radium and decaying products affecting the bones of medical patients, phosphorus 32 and its decaying products causing acute leukemia in medical patients, and radioiodines affecting the thyroids in children and adolescent survivors of nuclear reactor accidents.

New research is being reported daily so if you are in need of care for this type cancer ask you physician about the current natural products being used.