Posts Tagged ‘GIST’

Are People with Gastrointestinal Tumors at a Higher Risk for Other Cancers?

Wednesday, May 6th, 2015

Are People with Gastrointestinal Tumors at a Higher Risk for Other Cancers

In a new study published in Cancer that was the first population-based study looking at the association between gastrointestinal tumors (stomal) (GIST) and other tumors researchers concluded that one in 5.8 patients with GIST will develop additional malignancies before or after their diagnosis. Specifically, they are more likely to develop other sarcomas, non-Hodgkin’s lymphoma, carcinoid tumors, melanoma, colorectal, esophageal, pancreatic, hepatobiliary, non-small cell lung, prostate and renal cell cancers. They further found “Only 5 percent of patients with gastrointestinal stomal tumors have a hereditary disorder that predisposes them to develop multiple benign and malignant tumors.”

In the US population, researchers found people with gastrointestinal tumors had a 44 percent increased prevalence of cancer occurring before a GIST diagnosis and 66 percent increase of it occurring after a diagnosis. The most common tumors found were those of the genitourinary tract, breast, respiratory and blood. In addition, non-hispanic patients had a higher of other cancers before  a GIST diagnosis.  Patients with tumors smaller than 10 centimeters had a higher risk of a second cancer than patients whose growth were larger, and those whose tumor was smaller than 2 cm had the greatest likelihood of developing additional malignancies that occurred both before and after.

Although the mechanism for this finding is unknown, researchers say patients with this condition may warrant consideration for additional screening based on the other cancer that they are more susceptible to contact.