Posts Tagged ‘gold nanoparticles’

One dollar blood test using gold nanoparticles more effective than PSA test in prostate cancer detection.

Wednesday, April 8th, 2015

Prostate Cancer Detection with gold nanoparticles

A new study published in ACS Applied Materials & Interfaces concluded that a test using gold nanoparticles to detect early stage prostate cancer costs less that $1, has results in minutes and is more accurate than standard PSA screening. The gold particles attract cancer bio markers. The researchers test detects the immune response that the body produces in response to the development of a tumor. The gold nanoparticles are about 10,000 times smaller than a freckle.  When blood from a finger prick is mixed with the gold nanoparticles, certain cancer biomarkers cling to the surface of the tiny particles. increases their size and causes them to clump together. In the test they are able to measure the size of the particles by analyzing the light thrown off and the size reveals whether or not the patient has prostate cancer and how advanced it may be. Researchers said “Whats different and unique about our technique is it’s a very simple process, and the material required for the test is less than $1. And because it’s low cost, we’re hopinf most people can have this test in their doctor’s office. If we can catch this cancer in its early stages, the impact is going to be big.”

Evaluation of the test determined at 90 to 95 percent that it is not false positive, and with 50% confidence that it is not false negative which is higher than the PSA confidence in false positive at 20%. More research is planned with the eventual goal of hqving a simple, cheap test for various cancer types.

Can Expired Breath Be Used in Lung Cancer Detection?

Friday, December 23rd, 2011

In a new study published in the journal Nanomedicine researchers showed that a new device distinguishes between volatile organic compounds in the exhaled breath of cancer patients from those of a control group without cancer. Subjects exhaled into a bag that separated superficial exhaled breath from that originated deeper in the lungs and then analyzed the deeper breath using an array of gold nanoparticle sensors.
The metabolism of lung cancer patients is different from the metabolism of those without cancer and consequently, the molecules making up the expired air are also different. Using gold nanoparticles to trap and define molecules in exhaled air the new device can tell if the lung is cancerous, and whether it is small cell or non-small cell, adenocarcinoma or squamous cell carcinoma.
The researchers say the device could be used to diagnose lung cancer and also to look at differences over time to determine if a treatment is effective. The device would also reduce cost of diagnoses and increase the efficacy of diagnosis because, for example, one previous study of 53,000 subjects found that using low-dose chest CT scans to detect lung cancer gave a near 95 percent false positive. Thus, the new device has hope for better diagnosing of lung cancer.