Posts Tagged ‘head and neck cancer’

Can Compounds in the Magnolia Help Cure Head and Neck Cancer?

Wednesday, July 1st, 2015

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A new study on cancer and magnolia, published in the online journal of Oncotarget says the magnolia is a potent cancer killer. The study focused on squ7amous head and neck cancer cancers that are common among tobacco and alcohol users who account for 3 in 4 head and neck cancers and have a 50% survival rate.

A major active ingredient  in magnolias called honokiol, C18H18O2, has been used for centuries in traditional Chinese and Japanese medicine for centuries to treat anxiety and other conditions, and more recently found yo be a versatile adversary of cancer. It seems to destroy biochemical pathways to shrink tumors, or to keep them from growing in the first place. Specifically the current researchers have shown that it blocks a protein called epidermal growth factor receptor, EGFR, and prior research showed an abundance of this protein in head and neck cancer cells. Researchers say this this chemical binds more strongly with EGFR than the drug, gefitinit or Iressa, that is commonly used to treat head and neck cancer.

Researchers tested the honokiol on cell lines from human cancers of the head and neck and found it shut down the aberrant cells. Using it for cells implanted into mice produced similar results. They concluded “Conclusively, honokiol  appears to be an attractive bioactive small molecule photochemical for the management of head and neck cancer which can be used either alone or in combination with other available therapeutic drugs.”

 

Is Smoking Associated with an Increased Risk of Developing a Second Smoking-Related Cancer?

Wednesday, November 19th, 2014

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A new study published in the J of Clinical Oncology that analyzed five large prospective cohort studies reported that lung cancer (stage 1) bladder, kidney., and head and neck cancer survivors who smoked 20 or more cigarettes a day prior to their cancer diagnosis have an up to five-fold higher risk of developing a second smoking-related cancer when compared to survivors of the same cancer who never smoked. This association of smoking and 2nd cancer  was similar to smoking and primary cancers.

Researc hers said “As survival improves for a number of smoke-related cancers, patients are living longer, however,, smoking may increase the risk of developing a second smoking-related cancer among these survivors.” They continued on to say that health care professionals should emphasize the importance of smoking-cessation to all patients, including cancer survivors.

Data for these results included 5 prospective studies which included 2,552 patients with stage 1 lung, 6.386 with bladder, 3,179 with kidney, and 2,967 with head and neck cancer.  A total of 866 second primary smoking-related cancers were diagnosed among the survivors and the association between smoking status prior to primary cancer diagnosis and second smoke-associated cancer risk were assessed. In all four groups those who smoked   20 or more cigarettes daily prior to their first diagnoses were more likely to develop aa second smoking-related cancer when compared to the cohort who never smoked. These risks ranged from 3.3 times more like to 5.3 times more like likely depending upon the site of the cancer. In addition, those who were current smokers but smoked under 20 cigarettes a day or former smokers who quit before their first cancer diagnosis also had an elevated risk of developing a second primary cancer than those who never smoked.

Can Grape Seed Extract Kill Cancer Cells?

Wednesday, February 1st, 2012

A new study published in the journal Carcinogenesis concluded that in both cell line and mouse model studies, grape seed extract killed head and neck squamous carcinoma cells without harming healthy cells. Although heard of less often than breast, prostate and lung cancer, this cancer will kill nearly 12,000 people this year in the United States and over half-a-million people worldwide. The researcher says “cancer cells are fast growing. Not only that =, but they are necessarily fast growing. When conditions exist in which they can’t grow they die.” Grape seed extract produces the condition that are unfavorable to their growth. The research showed that grape seed extract damages the DNA of cancer cells and also stops the pathways that allow repair. And at the same time there was no toxicity to the mice. The researcher said that cancer cells have a lot of defective pathways and are vulnerable if you target them. However, this is not true of healthy cells. The researchers plan further research using clinical trials.

Shorter Head and Neck Cancer Patient's Survival Associated with Stress and Depression

Friday, May 6th, 2011

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In a study presented at the 32nd Annual Meeting and Scientific Sessions of the Society of Behavioral Medicine last month, researchers found an association between survival in early stage cancer patients and psychosocial function. Following upon research that shows that stress can affect the immune system and weaken the cancer patient’s defenses and also affect the tumors ability to grow and spread the researchers found that poor psychological functioning was associated with greater vascular endothelial growth factor (VEGF) expression. This signaling protein stimulates tumor growth and is associated with shorter disease-free survival in head and neck cancer patients.

In their study, 37 newly diagnosed, pre-surgical head and neck cancer patients were evaluated to see if psychological functioning (perceived stress, social support and depression) was associated with VEGF. Subjects were mostly male (70.3%). average of 57 years of age, and with a primary tumor site in the oral cavity (65.9%), larynx (19.9%). and oropharynx (13.5%), and early-stage disease (over 40%).
Subjects were given a psychological questionaire prior to treatment that measured psychological functioning. In addition, VEGF expression in tumor tissue was obtained during surgery and evaluated using a process that helps detect the presence of specific proteins. Results showed that higher levels of perceived stress and depression symptoms were associated with greater VEGF expression in the tumor tissue of these patients and the association between psychological functioning and VEGF were stronger among early-stage subjects. Researchers concluded that “In patients with advanced cancers, psychosocial interventions may have less of an impact since these cancers are inherently more aggressive.”
More research is planned.