Posts Tagged ‘high fat diet’

Colorectal Cancer Impacted by High Fat Diets

Wednesday, July 12th, 2017

Cancer stem cell growth in the colon is enhanced by a high fat western diet according to new research in Stem Cell Research. It has been known that 80% of colorectal cancers are associated with poor diet but until now the mechanism was unknown. In their pre-clinical model the cancer stem cell growth in the colon, believed to be partially responsible for the spread and recurrence of cancer, was enhanced by a high-fat Western diet  when researchers blocked the JAK2-STAT3 cellular signaling pathway, a pathway known to promote tumor growth, the spike in cancer stem cell growth caused by the high fat diet declined.

Researchers said “We have known the influence of diet on colorectal cancer. However, these new findings are the first to show the connection between high-fat intake and colon cancer via a specific molecular pathway.” “We can now build upon this knowledge to develop new treatments aimed at blocking this pathway and reducing the negative impact of a high-fat diet on colon cancer risk.”

Is a Hi-Fat High-Fructose Diet Worse for the Body than a High Fat Diet Alone?

Friday, July 4th, 2014


A new study published in Experimental Physiology concluded that a high-fructose, high fat diet can cause harmful effects to the livers of adult rats. Thus, the short term consumption of a Western diet that is rich in saturated fats and fructose, is more damaging to healthy livers that eating a high fat diet alone.  In the study using an  adult rat model resembling adult sedentary humans, ,rats were fed over a two week period  either a low-fat diet, a high fat diet or a diet rich in fat and fructose. The later diet is similar in composition to the diet consumed by the lkarge majority of the Western population. After the two week period, researchers evaluated liver function and found that the presence of fructose in the high-fat diet exacerbated the impairment of this important organ by increasing the build-up of fat in the liver, and decreasing liver insulin sensitivity. Researchers concluded “Much more research should be undertaken in the future, especially regarding the impact of the high-fat high-fructose diet on other metabolically important organs, in order to establish the real impact of this unhealthy dietary habit on health and well-being. “

Can A High-Fat Diet During Pubery Speed Up Development of Breast Cancer?

Friday, December 6th, 2013

logo1267406_mdA new study published in the recent online issue of Breast Cancer Research concluded that eating a high-fat diet beginning at puberty speeds up the development of breast cancer and may actually increase the risk of cancer often found in young women. In this preclinical model, researchers found that before tiumors appear,  there are changes in the breast that include increased cell growth and alternations in immune cells. These changes persist into adulthood and can lead to rapid development of precancerous lesions that may ultimate become breast cancer.

The researchers said :It’s important to note that since our experimental model did not involve any weight gain from the high fat-diet, these findings are relevant to a much broader segment of the population than just those who are overweight.” This shows the culprit is the fat rather than the weight gain.” They further dsaid the fat. ehich was saturated animal fat, could potentially  have permanent effects even if a low-fat-diet is used later in life. They concluded that from this preliminary study it shows avoiding this type of dietary fat may lower one’s risk of breast cancer down the road.

Lose Weight to Reduce Cancer Risk?

Friday, February 12th, 2010


Research published in the January 22 issue of Cell confirmed that obesity in mice increased the risk of cancer especially liver cancer. In their study the researchers gave 2 week old mice DEN ( a chemical carcinogen) and divided them into two groups. One group was fed a normal diet that was relatively low in fat and the other group a diet high in fat. The high fat group developed more liver cancer than the normal diet group. To further confirm the link between obesity and liver cancer they gave 2 week old mice DEN that were fed a normal diet but were prone to obesity. This group also developed more liver cancer so the researchers concluded that it was not necessarily the high fat diet but something about the obesity state. They also gave DEN to 3 month old mice on a high fat diet and they also developed more liver cancer. Usually mice on a standard diet given DEN at this age without the extra push of phenobarbitol do not develop liver cancer. But the obese mice developed liver cancer without the extra push of phenobarbitol. The researchers traced the source of the obese cancer producing effect to a rise in inflammatory factors and obese mice lacking these did not show the same rise in liver cancer nor the same distribution of fat in the body. This study suggests that anti-inflammatory drugs used for rheumatoid arthritis and Crohn’s disease may also reduce the risk of cancer for those at high risk of liver cancer because of obesity. .