Posts Tagged ‘high fat’

Miriam Kalamian demystifies Keto Diet for Cancer.

Sunday, June 16th, 2019

Miriam Kalamian is a nutrition consultant, educator, author, and speaker with a passion for ketogenic therapies. She earned her Master’s in Education from Smith College and her Master’s in Human Nutrition from Eastern Michigan University. She’s board certified in nutrition by the Board for Certification of Nutrition Specialists (CNS). Miriam was inspired by the groundbreaking work of Thomas Seyfried, who introduced her to the ketogenic diet for cancer a few years into her young son’s treatment for a devastating brain tumor. Now, in her book Keto for Cancer, Miriam demystifies the diet for those who want to apply this nutritional strategy as part of a metabolic approach to cancer. More information at:

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Is there an Association between a High-Fat, High Caloric Diet and Pancreatic Cancer?

Friday, October 11th, 2013

logo1267406_mdA new study published in the journal Cancer Prevention Research concluded that mice made obese by being given , high-fat, high-calorie diets (HFCD) developed abnormally high numbers of lesions known as pancreatic intraepithelial neoplasies (PaniNs) that are known to be precursors to pancreatic cancer. Thus, being the first study to show a link bewtween obesity and the tisk of pancreatic cancer (one of the most deadly forms of cancer) in an animal model.

Researchers studied diet-induced obesity and the development of pancrea cancer in a set of mice and then compared them to another set of mice that were genetically identical but not given the high-fat, high calorie diet. They also assessed the impact of the effects of the high-fat, high calorie diet on mouse pancrea tissue, such as an increased inflammation and other signs of pancreatic problems. These  indicators were measured to creaste an overall score (pancreatitis-score) to indicate negative effects on the pancreas. They also studied pancreatic tissue to determine how many PaniN precursor leisions had developed.

Mice eating the normal diet gained approximately 7.2 grams over 14 momths whereas those who ate the high fat/high calorie diet gained an average of 15.9 grams and mice fed the normal diet had mainly normal pancreas with very few scattered PaniN lesions but the mice fed the high fat.high calorie diet had significantly more PaniN leisions and fewer overall healthy pancreas. The study showed mice on the high fat/high calorie diet gained significantly more weight, had abnrmalities of their metabolism and increased insulin levels, and had marked pasncreatic tissue inflammation and development of PaniN leisions. This  strongly suggest that a diet high in fat and calores leads to weight gain, metabolic disturbances, can cause pancreatic inflammation, and promotes pancreatic leisions that are precursors to cancer according to the researchers.


A Breast Cancer Risk Factor May be a Diet High in Fat and Cholesterol.

Wednesday, January 12th, 2011


In a recent study publishes in the American Journal of Pathology researchers concluded that high levels of fat and cholesterol in the typical American diet is a risk factor in the growth and development of breast cancer. Using a mouse model with subjects and a controls predisposed to develop mammary tumors those fed a Western diet high in fat developed larger tumors that were faster growing and metastasized more easily than the mice eating a control diet. Although dietary fat and cholesterol have been shown to be a risk factor in tumor development and progression the results of diet-based studies in humans have been contradictory. Consequently; the researchers used animal models of human cancer to evaluate a link between cholesterol, diet and cancer.

All mice predisposed to breast tumors were placed on a diet containing 21.2 percent fat and 0.2 percent cholesterol that is reflective of a typical Western diet (subjects) or a diet of 4.5 percent fat and minimal cholesterol (control group). Tumors began to grow quickly in the research subjects and were double in number and 50 percent larger than those in the control group. There was also a trend toward an increased number of lung metastasis in the subjects. Biomarkers of tumor progression also confirmed more advanced cancer stage in the subjects compared to the controls.

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