Posts Tagged ‘immune cells’

Experimental Study Shows Increased Survival of Prostate Cancer Patients Using Frozen Immune Cells

Friday, June 10th, 2011

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Research presented at the annual meeting of the American Society of Clinical Oncology in Chicago on June 4 concluded that metastatic prostate cancer patients who received a vaccine made from their own frozen immune cells lived up to 10 months longer than those who did not receive this intervention. In this exploratory study immune cells (APC8015F) are taken from prostate cancer patients before the disease progresses and frozen. Results showed that following progression, those treated with APC8015F had a median survival rate of 20 months compared to 9.8 months for those not treated with APC8015F. Further research is planned.

Inflammation and Cancer Growth and Metastasis

Wednesday, January 19th, 2011

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In a new study being published in the net edition of Cancer Cell researchers demonstrated that HRG (histidine-rich-glycoprotein), a protein that naturally occurs in the body will inhibit the growth and spread of cancer cells by activating specific immune cells. However, this process is dependent upon inflammatory cells which are caused by most cancers and may either stimulate the growth of tumors or inhibit them. This cancer caused inflammation consisting of tumor associated macrophages (TAM’s) that are either M2 macrophages that support cancer cell growth and moderate the body’s immune defense, or M1 macrophages that inhibit tumor growth by activating immune cells that are toxic to the tumors.

The researchers say “”HRG can transform inflammatory cells in the tumor from M2 macrophages, which promote tumor growth, to M1 macrophages, which inhibit tumor growth” and “M1 macrophages also inhibit the spread of tumor cells….”.

Studying 3 different types of tumors in mice they found the tumors producing HRG grew more slowly and did not spread. In the process the HRG caused M2 macrophages to transform into M1 macrophages. Further research is planned.

Additional information can be found at:
http://www.eurekalert.org/pub_releases/2011-01/uu-sci010511.php

New Approach May Halt or Reverse Rheumatoid Arthritis

Wednesday, February 10th, 2010

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New research to be published in the February issue of Arthritis & Rheumatism discussed a novel way to halt or reverse rheumatoid arthritis by using am imitation of a suicide molecule that floats undetected into immune cells that are responsible for this type of arthritis. Using this approach the researchers were able to stop the disease in 75% of the study mice without any observed toxic effects as is the case with current drugs. The mechanism is that healthy immune cells usually die after attacking an invading virus or bacteria. However, in rheumatoid arthritis the immune cells do not die but live on and go rogue proliferating in the blood, building up in the joints and invading cartilage and bone.

Researchers discovered that immune cells in rheumatoid arthritis are low in a critical molecule (Bim) that cause the immune cells to self- destruct. To correct this fault they developed an imitation of this molecule (called BH2) that was injected into study mice with rheumatoid arthritis that caused the immune cells to destruct, joint swelling was reduced and bone destruction decreased. Thus, they concluded that the molecule could prevent the disease and trigger a remission in those who have it. Further research is planned to develop a more precise method of delivering the drug.