Posts Tagged ‘improve cancer risk’

Can A Healthy Lifestyle Reduce Risk for High Risk Breast Cancer Patients.

Wednesday, June 1st, 2016

Holistic-Health-Show-with-Dr-Carl-O-Helvie

A new study published in May, 2016 in JAMA Oncology  concluded that women with a high risk of developing breast cancer based upon family history and genetic risk can reduce the chances of developing the disease by following a healthy lifestyle. Researchers developed a model predicting the risk of breast cancer by analyzing records of more than 17,000 women with breast cancer and nearly 20,000 women without the disease and another 6,000 women from another study group. Individual-level data on risk such as age, weight, smoking status, and  factors on almost 100 common gene variations, each of which are known to have a modest association with breast cancer but in combination they can lead to substantial elevated risk. The common gene variations in the study were quite different from the well known rare mutations in genes such as BRCA1 and BRCA2 where having a single variant can mean a very high risk of developing cancer.

They found that roughly 30 percent of breast cancer cases could be prevented by modifying known risk factors such as drinking less alcohol, losing weight and not taking hormone replacement therapy. They also found that a large fraction of the total preventable cases would occur among women at higher levels because of genetic risk factors, family history and a few other factors that cannot be modified. They found that white women who are at high risk but who had a low body index mass index, who did not drink or smoke, and who did not use hormone replacement therapy, had about the same risk as an average white woman in the United States and that the average chance that a 30 year old white woman will develop breast cancer before age 80 is about 11 percent. Researchers said “People think that their genetic risk for developing cancer is set in stone,. While you can’t change your genes, this study tells us even people who are at high genetic risk can change their health outlook by making better lifestyle choices such as eating right, exercises, and quitting smoking.”

This study is a first step in understanding how advances in the field of genetics can be used to develop preventive strategies to help women improve their odds of avoiding breast cancer.

 

 

 

 

 

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