Posts Tagged ‘increased risk’

Can Smoking Interfere with Breast Cancer Treatment?

Friday, June 24th, 2016


Logos 005New research published in the British Journal of Cancer  concluded that common treatment for breast cancer works less well in patients who smoke, compared to non-smokers. The study followed 1,016 breast cancer patients in southern Sweden diagnosed between 2002 and 2012. At the time of surgery they were asked whether they were smokers or non-smokers and about one in five said they were a regular smoker or social smoker. The impact of smoking was evaluated based upon type of breast cancer treatment received after surgery.

Results showed that women over age 50 treated with aromatase inhibitors, were affected by smoking. The aromatase treatment prevents the body from generating estrogen in fatty tissue and thereby reduces the risk of recurrence in women with estrogen-receptive positive breast cancer. This treatment worked significantly better in non-smokers. Researchers said “Smokers who were treated with aromatase inhibitors had a three times higher risk of recurrence of breast cancer compared with the non-smokers who got the same treatment.” They also found that “the smokers also had an increased risk of dying, either from the breast cancer or from other illnesses, during the time we followed them.”

However, the researchers found little or no difference between smokers and non-smokers treated with the drug tamoxifen, radiotherapy, or chemotherapy. Despite telling patients of the importance of stopping smoking only ten perce of the 206 smokers stopped in the first year after surgery. Researchers said the number of smokers who stopper was too small to determine if that made a difference in their future risk. More research is needed.

A gene variant increases colorectal cancer risk from eating processed meat.

Friday, April 25th, 2014

logo1267406_mdResearchers in a new study in PLOS Genetics reported that a common gene variant that affects one in 3 people seems to increase the risk of colorectal cancer from the consumption of processed meat. Data from over 9,200 patients with colorectal cancer and over 9,100 controls were pooled. Over 2 million variants were analyzed to find those associated with the consumption of meat, fiber, fruits and vegetables and found a significant interaction between the variant rs4143094 and processed meat consumption. This variant was found on the same chromosome 10 region of another gene that was previously linked to several forms of cancer. Colorectal cancer is a multi-factor disease process that has both genetic caused and lifestyle factors including diet. About 30 known genetic susceptibility alleles for colorectal cancer have been identified but the effect of specific foods on the activities of the genes has not been found. The researchers said “The possibility that genetic variants may modify an individual’s risk for disease based on diet has not been thoroughly investigated but represents an important new insight into disease development.”  They further said”Diet is a modifiable risk factor for colorectal cancer. Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile.  This information helps us better understand the biology and maybe in the future lead to targeted prevention strategies.”

Does radiation therapy for cervical cancer increase your risk of later colorectal cancer?

Wednesday, April 23rd, 2014

logo1267406_mdIn a recent study published online in the journal Medical Oncology researchers found that young women treated with radiation for cervical cancer had a higher incidence of secondary colorectal cancer later in life than women who were not treated with radiation therapy. As a result they recommended earlier colorectal cancer screening for this group than earlier recommended starting at about 8 years after treatment instead of waiting until age 50.

Researchers analyzed data on over 64,500 cervical cancer cases collected between 1973 and 2009. Among cervical cancer survivors studied, colon, rectum, and anus tumors were found to be two to four times more frequent in the group treated with radiation than in the group not treated with radiation. The rate of colorectal cancer in the group receiving radiation for cervical cancer varied by time and began about 8 years after treatment and increased over time until after 35 years they were 3 to 4 times more like to develop colorectal cancer than women who had not had radiation.

Does Radiation Therapy for Uterine Cancer Increase Risk of Later Bladder Cancer?

Friday, January 3rd, 2014

logo1267406_mdA new study published in BJU International concluded that radiation therapy used to treat uterine cancer may increase the risk of later developing bladder cancer for those patients. Records of 56,681 women diagnosed with uterine cancer as their first primary malignancy between 1980 and 2006 were analyzed. W9th an average follow up of 15 years bladder cancer incidence in uterine cancer patients treated with pelvic radiation therapy was twice as high as that seen in patients treated without radiation. Likewise, the death rate from bladder cancer was nearly three times higher in patients treated with pelvic radiation that with those who did not receive radiation. Although previously it was thought  that bladder cancer that developed after pelvic radiation tended to be aggressive with high grades and stages  this study found the types, grades and stages of bladder cancer that developed were similar in patients treated with and without radiation therapy. Researchers concluded that “physicians who care for patients with a history of uterine cancer and pelvic radiation treatment should keep in mind the increased risk of bladder cancer.”

Can a Woman’s Height Affect Her Cancer Risk?

Friday, August 2nd, 2013

logo1267406_mdA new study published in Cancer Epidemiology, Biomarkers,& Prevention concluded that the taller a postmenopausal woman is, the greater her risk for developing cancer. In this study of over 20,900 postmenopausal women the association of height was linked to breast, colon, endometrium, kidney, ovary, rectum, thyroid, multiple myeloma, and melanoma and the associations did not change when adjusting for factors known to influence these cancers. . The researchers said “We were suprised at the number of cancer sites than were positively associated with height. In this data set, more cancers are associated with height than were associated with body mass iindex (BMI).” They further said “Ultimately, cancer is a result of processes having to do with growth, so it makes sense that hormones or other growth factors that influence height may also influence cancer risk.”

Postmenopausal women in the study were between ages 50 and 79  and data was collected between 1993 and 1998. When entering the larger study of over 144,700 women they answered questions about physical activity and their height and weight were measured. Over the next 12 years the 20,900 sample was selected because all were diuagnosed with one or more invasive cancers, In order to study the effdect of height researchers collected data on a variety of factors that may account for cancer icluding age, weight, education, smoking habits, alcohol consumption, and hormone therapy.

Findings showed that for every 3.94 inches increase in height there was a 13% increase in risk of developing any cancer. Among specific cancer4s there was a 13 percent to 17 percent increase in getting melanoma and cancer of the breast, ovary, endometrium, and colon. There was a 23 to 29 percent increase in the risk of developing cancers of the kidney, rectum, thyroid, and blood. Of the 19 cancers studied, none showed a negative association with height.