Posts Tagged ‘low fat diet’

Does a Low Fat Diet Effect Cancer Death?

Wednesday, April 20th, 2016

A new study presented at the American Association for Cancer Research annual meeting concluded that women who stay on a low fat diet for about eight years  reduce their risk of death from invasive breast cancer and improve their survival rate when compared with women who had not stayed on a low fat diet. Researchers followed 48,835 postmenopausal women between the ages of 50 and 79 with no previous breast cancer. In this randomized clinical trial the women had also had normal mammograms and normal dietary fat intake.  Of this group, 19,541 women were placed on a low fat diet with nutritionist-led group sessions attempting to reduce fat intake  to 20% of energy and increase consumption of fruit, vegetables, and grain. The other 29,294 women followed their usual dietary pattern.

Following about eight years on the low fat diet, 1,767 women were diagnosed with breast cancer. Overall survival from diagnoses of breast cancer was higher in the study group: 82% vs 78%. They believed the reduction was partly due to better survival following the breast cancer diagnosis. Researchers said “This was the first time we had examined the death after breast cancer among this group, and we found that a sustained low fat diet increased the survival rates among postmenopausal women after a breast cancer diagnosis.” They continued “The study also suggests that women would need to remain on the low fat diets to maintain the benefits of the dietary intervention.”

Researchers also found that most breast cancer characteristics such as size, nodal status, and distribution of poor prognosis, triple negative cancers and HER2 positive cancers were similar in the two groups of women. However,m there were fewer progesterone receptor negative cancers in the study group (28.4% vs 33%) and they also  found a lower cardiovascular disease mortality in the study group.

Is a Hi-Fat High-Fructose Diet Worse for the Body than a High Fat Diet Alone?

Friday, July 4th, 2014


A new study published in Experimental Physiology concluded that a high-fructose, high fat diet can cause harmful effects to the livers of adult rats. Thus, the short term consumption of a Western diet that is rich in saturated fats and fructose, is more damaging to healthy livers that eating a high fat diet alone.  In the study using an  adult rat model resembling adult sedentary humans, ,rats were fed over a two week period  either a low-fat diet, a high fat diet or a diet rich in fat and fructose. The later diet is similar in composition to the diet consumed by the lkarge majority of the Western population. After the two week period, researchers evaluated liver function and found that the presence of fructose in the high-fat diet exacerbated the impairment of this important organ by increasing the build-up of fat in the liver, and decreasing liver insulin sensitivity. Researchers concluded “Much more research should be undertaken in the future, especially regarding the impact of the high-fat high-fructose diet on other metabolically important organs, in order to establish the real impact of this unhealthy dietary habit on health and well-being. “

Human Prostate Cancer Cells Slowed by Low Fat Diet with Fish Oil

Friday, November 4th, 2011


A new study reported in Cancer Prevention Research concluded that men who ate a low-fat diet with fish oil supplements from 4 to 6 weeks before having their prostate removed had slower cancer-cell growth in their prostate tissue than men who ate the typical high-fat Western diet. The cell membrane of both healthy and cancer cells in men on the low-fat diet with fish oil supplements also showed changes in that there were higher levels of omega-3-fatty acids from fish oil and lower levels omega-6-fatty acids from corn oil. Researchers also found that blood from patients using the low-fat supplemented by fish oil diet slowed the growth of prostate cancer cells in a test tube whereas blood from those on the typical diet did not. The researcher said “The findings that the low-fat, fish oil diet reduced the number of rapidly growing cells in the prostate cancer tissue is important because the rate at which the cells are dividing can be predictive of future cancer progression. The lower the rate of proliferation, the lesser the chances that the cancer will spread outside the prostate, where it is much harder to treat.”

The study included 48 men followed over 6 weeks. Men in the low-fat fish oil supplemented diet group were provided food to assure that they followed a low-fat diet supplemented with fish oil The diet provided 15 percent of the calories from fat and was supplemented with 5 grams of fish oil daily. The typical diet provides 40 percent of the calories from fat and usually has high levels of omega-6 fatty acids from corn oil and low levels of fish oil that provides omega-3 fatty acids and that have been found to reduce the incidence of heart disease and to fight inflammation that has been associated with certain types of cancer.

The researchers warn against generalizing from this study because of the small numbers and short period of study. Another study in planned that will include 100 men with prostate cancer who have elected to wait and see without any treatment but will receive biopsies and check-ups. The study will randomly divide men into two groups-the low fat fish oil supplemental diet and the typical western diet and follow them for 1 year to evaluate the effect of diet on prostate cancer cell proliferation.

Lose Weight to Reduce Cancer Risk?

Friday, February 12th, 2010


Research published in the January 22 issue of Cell confirmed that obesity in mice increased the risk of cancer especially liver cancer. In their study the researchers gave 2 week old mice DEN ( a chemical carcinogen) and divided them into two groups. One group was fed a normal diet that was relatively low in fat and the other group a diet high in fat. The high fat group developed more liver cancer than the normal diet group. To further confirm the link between obesity and liver cancer they gave 2 week old mice DEN that were fed a normal diet but were prone to obesity. This group also developed more liver cancer so the researchers concluded that it was not necessarily the high fat diet but something about the obesity state. They also gave DEN to 3 month old mice on a high fat diet and they also developed more liver cancer. Usually mice on a standard diet given DEN at this age without the extra push of phenobarbitol do not develop liver cancer. But the obese mice developed liver cancer without the extra push of phenobarbitol. The researchers traced the source of the obese cancer producing effect to a rise in inflammatory factors and obese mice lacking these did not show the same rise in liver cancer nor the same distribution of fat in the body. This study suggests that anti-inflammatory drugs used for rheumatoid arthritis and Crohn’s disease may also reduce the risk of cancer for those at high risk of liver cancer because of obesity. .