Posts Tagged ‘Lynch Syndrome’

Does Lynch Syndrome Increase Your Risk of Breast and Pancreatic Cancers?

Friday, February 24th, 2012

A new prospective study published in the Journal of Clinical Oncology concluded that people with Lynch Syndrome face significantly increased risks of breast and pancreatic cancers and the relatives of those individuals who do not have the genetic mutation associated with the condition do not have a higher risk of developing cancer than the general public. You may ask “What is Lynch Syndrome?” It is an inherited disorder caused by mutation in specific DNA repair genes. The researchers claimed “Our study is the first prospective analysis to find a strong association between breast cancer and Lynch syndrome.”
In the study researchers followed 446 carriers of one of four mismatch repair mutations related to Lynch Syndrome and 1,029 of their relatives without the mutation. Study subjects were evaluated every five years. After a median follow-up of five years carriers had a 20-fold greater risk of colorectal cancer, a 30-fold greater risk of uterine cancer, a 10-fold higher risk of pancreatic, stomach, and bladder cancers, a 19-fold higher risk of ovarian cancer, and a four-fold higher risk of breast cancer than the general population. Results also showed that carriers tended to be diagnosed at an earlier age than the general population and family members without the mutation had risks comparable to the general population.