Posts Tagged ‘melanoma’

Dr Gaston Cornu-Labat discusses BEC-a non-invasive very successful treatment for Skin Cancers.

Sunday, July 28th, 2019

Holistic and Integrative Physician and Surgeon, Gastón Cornu-Labat, MD graduated from Facultad de Medicina, Universidad de Buenos Aires, Argentina in 1991. He obtained his specialty title in general surgery from Northeastern Ohio Universities College of Medicine in Youngstown, Ohio in 2001 to then specialize in liver and pancreatic surgery at Virginia Mason Medical Center in Seattle, Washington and became a member of the Pancreas Club, Inc.
Licensed over the past decades in the states of Ohio, Nebraska, Washington, and Texas, after years in academic surgery leading research, numerous publications and international presentations in diverse fields pertaining to his specialty, Dr. Gaston shifted in his career into the study and understanding of the human experience as a whole in all that relates to health and disease, and practiced as a rural surgeon in the US mid-west. He incorporated this understanding into his medical and surgical practice.
As a Holistic and Integrative medical practitioner, he later apprenticed to Jonathan V. Wright, MD and his team at the Tahoma Clinic in Seattle, WA building extensive expertise in natural, nutritional and antiaging medicine, to then serve as a practitioner at said clinic for 5 years. He also participated in numerous seminars for non-pharmacological pain management based on the technique discovered and developed by Dr. Stephen Kaufman, DC, Pain Neutralization Technique (PNT). Dr. Gastón authored with Dr. Kaufman’s contributions the book “PNT, An Unprecedented Revolution in Pain Management.” With this extensive knowledge base and experience he focused his practice in Integrative Oncology.
One of the featured experts at the documentary series “The Truth About Cancer: A Global Quest” in 2015, Dr. Gastón was also a featured speaker at the TTAC Live Symposium in 2016. He has participated in other documentaries, radio shows and media productions educating the public.
In February 2017 he joined the Hope 4 Cancer family as Chief Medical Advisor, bringing to the table a unique combination of knowledge and experience ranging from traditional medicines to conventional allopathic, and alternative and complementary healing modalities to the Tijuana and Cancun clinics in Mexico. As an integral part of the executive team, he contributed to develop and monitor success of treatment protocols and the educational programs for H4C staff doctors and nurses. He also supervised and managed complex patient cases.
At present, Dr Gaston is focused on research and development of cutting edge natural oncologic protocols for effective management of cancers.

Enjoy the Interview Below:

 

Bailey O’Brien, a 10 year stage 4 melanoma survivor, was current guest

Sunday, February 24th, 2019

Bailey O’Brien is a stage 4 melanoma survivor, cancer coach and community lover. In 2007 at the age of 17 she was first diagnosed cancer before she became terminal in 2011. Finding herself at the end of her conventional-wisdom-rope, Bailey took a chance on alternative methods including treatment at a Mexican hospital and a radical diet and lifestyle change. Despite the odds and by the grace of God, she was healed! Bailey’s healing prompted her quest for meaning, truth and purpose, and since finding it her life has been forever changed for the good. She now helps others with cancer and it brings her great joy to share her belief that in every situation there is always hope, health-related and otherwise. Bailey is living proof that with God, all things are possible! Her website is www.baileyobrien.com and you can find her on Facebook and Instagram at facebook.com/baileyobrien330 and Instagram.com/bailey330.

Enjoy the Interview below:

 

Origins of Cancer Uncovered.

Wednesday, February 3rd, 2016

logo1267406_mdA new study reported in Science concluded that researchers had visualized the origin of cancer, from the first affected cell and watched its spread in a live animal. This could change the way they understand cancer and lead to new early treatment before the cancer has invaded.

Researchers queried why some cells already have mutations seen in cancer, but do not fully behave like the cancer. They continued “We found that the beginning of cancer occurs after activation of an oncogene or loss of a tumor suppressor, and involves a change that takes a single cell back to a stem cell state.”  That change involving a set of genes could be targeted to stop cancer from ever starting.

Over time researchers imaged live zebrafish to tract development of melanoma and all had the human cancer mutation BRAFV600E–found in most benign moles–and had also lost the cancer suppression gene p53. Researchers engineered the fish so that individual cells would floresce green if a gene called crestin was turned on that indicated activation of a genetic program characteristic of stem cells. This program normally turned off after embronic development, but occasionally for some unknown reason crestin and other genes turned back on in certain cells. The researcher said “Every so often we would see a green spot on a fish.” When we followed them, they became tumors 100 percent of the time.”

They found that these early cancer cells are the crestin and the other activated genes are the same ones turned on during zebrafish embryonic development and these genes also get turned on in human melanoma. They believe these finding will lead to a new genetic test for suspicious moles to see if the cells are behaving like neural crest cells that would indicate the stem cell program has been turned on.

They postulate a new model of cancer formation that goes back to the concept of field-cancerization. In this model the normal cell vecomes primed for cancer when onvogenes are activated and tumor suppressor genes are silenced or lost, but the cancer develops only when a cell in the tissue reverts to a more primitive, embreyonic state and starts dividing and this model may apply to most if not all cancers.

Do Antioxidants Cause Malignant Melanoma to Metastasize

Wednesday, October 14th, 2015

Logos 005A new study published in Science Translation Medicine concluded that antioxidants can double the rate of melanoma metastasis in mice and reinforces previous research that antioxidants hasten the progression of lung cancer.  Researchers further said that those with cancer or the high risk of cancer should avoid   nutritional supplements that contain antioxidants. Because it was known that free radicals can cause cancer, the research community assumed that antioxidants that destroy them, provided protection against cancer. As a result many nutritional supplements included antioxidants as a cancer prevention.

Now research shows this not to be true. The current study on melanoma, the worst type of skin cancer, found that antioxidants doubled the rate of metastasis in malignant melanoma and as opposed to the lung cancer study the primary melanoma tumor was not affected. Researchers said “We have demonstrated that antioxidants promote the progression of cancer in at least two different ways.” They protect healthy cells from free radicals that can turn into malignancies but may also protect a tumor once it has developed. Thus, taking nutritional supplements containing antioxidants may unintentionally hasten the progression of a small tumor or premalignant tumor, neither of which is possible to detect. Thus, they say those recently diagnosed with cancer should avoid antioxidant nutritional supplements.

The role of antioxidants is particularily relevant with patients who have melanoma because melanoma cancer cells are know to be sensitive to free radicals and alsoi because the cells can be exposed to antioxidants by non-dietary means . “Skin and suntan lotions sometimes contain beta carotine or vitamin E, both of which could potentially affect malignant melanoma cells in the same way as antioxidants in nutritional supplements.”  The role of lotions on cancer and the effect of antioxidants on cancer are ongoing in research by this orgainzation.

NB:It is interesting that research published April 9, 2014 on this site concluded that vitamin A (beta carotine) prevented normal cells from reverting to cancer cells.

New Potential Treatment Target for Melanoma Discovered.

Friday, May 8th, 2015

New Potential Treatment for Melanoma

A new study published in the journal Clinical Cancer Research reported that researchers found high levels of an enzyme, interleukin-3  induced T-cell kinase (ITK) in melanoma cells that when blocked in pre-clinical studies in mice, reduced the cancer’s growth. This enzyme has not previously been explored as a driver of solid tumors and the researchers are hopeful blocking of the enzyme can be an effective treatment because one drug blocking the enzyme in blood and other cancer’s has been approved. Researchers said “We have discovered that ITK is highly expressed in melanoma even though it was thought to be restricted to immunity cells, and when you inhibit it, you decrease growth.” Five year survival rates for melanoma range from 98 percent to 16 depending on whether the cancer is localized or has spread and some treatments become ineffective so new treatments are needed.

Is Melanoma Linked to Socioeconomic Factors and Fashion Trends?

Friday, October 10th, 2014

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Retrospective research published in a recent issue of the American Journal of Public Health concluded that extenuating factors such as socioeconomic and fashion trends  have contributed to the increase of melanoma over the past century. Believing that early diagnosis and improved reporting practices  do not fully explain the steady increase in melanoma they explored factors that may also have contributed to the increase in the United States. These included the trans-formative effect of socioeconomic trends dating from the 1900’s such as clothing styles, social norms, medical paradigms, perceptions of tanned skin, economic trends, and travel patterns. For compoarison between periods they estimated percentage of exposed areas of the body. for example, early in the 20th century clothing almost totally covered the body from head to toe and porcelain skin was favored over tanned skin that was associated with the lower class who often worked outside. Changes in medical practice also added to shifts in attitudes and practices. For example, “In the early 20th century, sunshine became widely accepted as treatment for rickets and tuberculosis and was considered to be good for overall good health.”  The public translated this into a desire for tanning  and at the same time people began enjoying more leisure time outside and favored swimwear and sports that covered less of the body. Graphs tracking the incidence by year and percentage of estimated skin exposure show a parallel between these changes in lifestyle and belief and the rise in melanoma.

Can a Blood Test Detect All Types of Cancer?

Wednesday, August 6th, 2014

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New research published online in FASEB Journal, The U.S.Journal of American Societies for Experimental Biology, concluded that a revolutionary blood test that could detect any type off cancer was developed by British scientists. The test6 has been shown to diagnose cancer and pre-cancerous conditions from blood of patients with melanoma, colon cancer and lung cancer with a high degree of accuracy. Researchers assessed white blood cells and measured the damage caused to their DNA when subjected to different intensities of ultraviolet light that is known to damage DNA. They found a clear distinction between the damage to the white blood cells from patients with cancer, with precancerous conditions, and from healthy patients. They also found that  people with cancer have DNA that is more easily damaged by untraviolet light than other people.

Results were based upon blood samples of 206 people of which 94 were healthy and 114 were patients  in specialist clinics prior to diagnosis and treatment. Ultra violet damage was observed in the form of pieces of DNA being pulled in an electric field toward the positive end of the field, causing a comet like tail. The longer the tail the more the DNA damage and this correlated with patients who were ultimately diagnosed with cancer(58) and precancerous conditions (58) and those who were healthy (94). Further clinical research is evaluating the tests accuracy.

Reason Why People with Red Hair Have a Higher Risk of Developing Melanoma?

Wednesday, August 28th, 2013

logo1267406_mdA new research study published in Molecular Cell concluded that  a persons skin pigment, which determines hair color and skin tone, is influenced by the melanocortin-l (MClR) gene receptor. and those with red hair have a mutation in MClR accounting for the red hair. This same MRlC mutation also promotes an important cancer-causing pathway and helps to explains the molecular mechanism that underlies redheads well-known risk of developing melanoma

The researchers found from cell culture and mouse model research that under normal circumstances MClR was binding to PTEN, a well known tumor suppressor gene. PTEN acts to safeguard against cancer,but in those without PTEN, the end result is elevated signaling in the cancer causing P13/AKt pathway. Researchers then demonstrated that MClR-RHC mutations found in red-haired people lacked this protective mechanism., “As a result, upon UVB exposure (that can damage DNA and lead to melanoma), we saw an increased destruction of PTEN in the mutated pigment cells.” They also found that in the same MCiR/RHC pigment cells, elevated P13K/Akt activity was boosting cell proliferation and synchronizing with another well-known cancer mutation in the BRAF gene (found in close to 70% of all melanoma) to accelerate cancer development. Other researchers have also recently found that expression of the BRAF gene mutation in the melanocytes of mice carrying a mutant MClR gene led to a high incidence of invasive melanomas/ “Together, our findings provide a possible molecular mechanism as to why red-haired individuals harboring MCLR mutations are much more susceptible to UV-induced skin damage than individuals with darker skin, resulting in a 10-to-100 fold higher frequency of melanoma.”

Does a History of Non-Melanoma Skin Cancer Lead to An Increased Risk of Other Primary Cancers?

Friday, May 3rd, 2013

logo1267406_mdA prospective study from Brigham and Women’s Hospital reported in PLOS Medicine reported on an association between risk of second primary cancer and history of non-melanoma skin cancer in white men and women. They found that people with a history of non-melanoma skin cancer had a modest increase risk of getting cancer in the future, specifically breast and lung cancer in women, and melanoma in both men and women,

Data was analyzed from two cohort studies in the United States and followed over 46,000 men from June, 1986 to June 2008, and over 107,000 women from June, 1984 to June 2008. Over the period there were over 36,000 new cases of non-melanoma skin cancer, and over 29,000 new cases of other primary cancers. A history of non-melanoma skin cancer was significantly associated with a 15% higher risk of other primary cancers in men, and a 26% higher risk of other primary cancers in women.  When melanoma was excluded from the analysis, the rates change=d slightly, with a history if non-melanoma skin cancer associated with 11% higher rates of primary cancer in men, and a 20% higher rate of other primary cancers in women. Using statistical models to correct for multiple comparisons,  looking at individual cancer sites, they found that a history of non-melanoma skin cancer was significantly linked with an increase risk of breast cancer and lung cancer for women, and an increase risk of melanoma ion both men and women. However, because the study was observational the researchers advised caution about the results.

Can the Common Aspirin Lower the Risk of Melanoma?

Friday, March 22nd, 2013

logo1267406_mdA new study published early online in Cancer concluded that women who take aspirin have a reduced risk of developing melanoma, and the longer they take it, the lower the risk. It seems possible that the anti-inflammatory effects of aspirin may help protect against melanoma.

As part of the women’s Health Initiative researchers observed women between ages 50 and 79 for an average of 12 years and determined which developed cancer. At the beginning of observations women were asked medications being taken, foods they ate, and activities they performed.

They found that of the 59,806 Caucasian women included those who took the most aspirins were less likely to develop melanoma skin cancer during the twelve years in relation to those who did not take aspirins. Overall women who used aspirin has a 21% lower risk of melanoma and each incremental increase in duration of aspirin use (less than one year of use, one to four years of use, and five or more years of use) was associated with an 11% lower risk of melanoma. Consequently, women who used aspirin for five or more years had a 30% lower risk for melanoma than women who did not use aspirin. Differences in pigmentation, tanning practices, sunscreen use, and other factors that may affect skin cancer were controlled for. The researcher concluded that “Aspirin works by reducing inflammation and this may be why using aspirin may lower your risk of developing melanoma. “