Posts Tagged ‘mice study’

Intermittent fasting can help fight obesity.

Wednesday, October 25th, 2017

 

Intermittent fast for up to sixteen weeks without making other changes helps fight obesity and other metabolic disorders .  according to a new study published in in the journal Cell Research  Researchers found that intermittent fasting of mice kick started their metabolism and burning fat by generating heat. Groups of mice were exposed to sixteen weeks of intermittent fasting consisting of being fed for two days followed by one day without anything to eat. Their calorie intake was not adjusted otherwise. After four months the mice in the fasting group had lost more weight than those in the control group who continued to eat the same amount of calories. Weight loss in the fasting group was not the only change. There was a decrease in the build up of white fat by increasing the brown-like fat (involved in burning energy and producing body heat) and their insulin and glucose systems remained more stable. In addition,m these changes were seen after 6 weeks.  This was found to be a result of changes in pathways in the immune system and the bodies reaction to inflammation in which a type of white blood cells that play a role in fighting inflammation is triggered. This leads to stimulation of fat cells to burn stored fat or lipids by generating heat. The authors concluded that “intermittent fasting without a reduction of caloric intake can be a preventive and therapeutic approach against obesity and metabolic diseases.”.

Are Salmonella Bacteria a Possible New Treatment for Cancer?

Wednesday, November 2nd, 2016

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A new study published in PLOS ONE concluded that Salmonella has a unique characteristic allowing it to penetrate through a cell barrier and replicate inside its host. Scientist have now developed a non-toxic strain of Salmonella to penetrate and target cancer cells that may lead to treatments actively targeting and controlling the spread of cancer. The researchers said “Salmonella strains have a natural preference for infiltrating and replicating within the cancer cells of a tumor, making the bacterial an ideal candidate for bacteriotherapy. …..the use of live bacteria as therapy to treat medical conditions, like cancer.”

Researchers developed  CRC2631, a Salmonella strain that was genetically modified to render the bacteria non-toxic and enhance its natural ability to target and kill cancer cells without harming normal, healthy cells. This Salmonella strain was administered directly into the circulatory system of mice with prostate cancer. Results show that the mice tolerated the treatment well and the prostate tumors decreased by about 20% when compared with a control group,  The success of the study was dependent upon the strain of Salmonella, CRC2631, that was collected and stored in a test tube at room temperature for more than 50 years. It differs from that used by other researchers trying to obtain the same results because it is unique and essential to the study.

Will Exercise Improve Muscle Repair in Older Adults?

Wednesday, June 22nd, 2016

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New research published in The FASEB Journal concluded that regular exercise is important for muscles to repair themselves more quickly after injury. Although muscle repair slows as we age this study shows that contrary to previous beliefs that muscles did not completely repair with age that after only eight weeks of exercise, old mice experienced faster muscle repair and regained more muscle mass than those of the same age that had not exercised. Researchers said “Exercise per-conditioning may improve the muscle repair response in older adults to stimulate such an acute period of atrophy/inactivity and or damage.”

Researchers used three groups of mice: old mice that were exercise trained; old mice that were not exercises trained; and young mice that were not exercise trained. in the first group, old mice were trained three days/week for eight weeks and the effect of exercise in aging muscles was measured by comparing the three groups.  Changes in muscle repair with aging w2as measured by injecting snake venon that is commonly used to induce muscle injury in rodents, into the old and young non-exercise mice.  All three groups were compared prior to muscle injury, ten days after injury, and 28 days after injury, Researchers said “This is a clear demonstration that the physiological and metabolic benefits of exercise radiate to skeletal muscle satellite cells, the adult stem cells responsible for repair after injury, even in senescent animals.”

Can Beehive Extract Influence Prostate Cancer Outcome?

Wednesday, May 16th, 2012

Research published in Cancer prevention Research concluded that an over the counter natural remedy from honeybee hives arrest the growth of prostate cancer cells and tumors in mice. The compound, caffeic acid phenethyl ester (CAPE) is a compound isolated from honeybee hive peopolis, the resin used by bees to patch up holes in the hives. Researchers said” If you fee4d CAPE to mice daily, their tumors will stop growing. After several weeks, if you stop the treatment,. the tumors will begin to grow again at their original pace. ..So it doesn’t kill the cancer, but it basically will indefinitely stop prostate cancer proliferation.”

In their research, they tested the compound, CAPE, onm a series of cancer cell lines and found that at even low concentrations after oral administration, it successfully slowed the proliferation of cultured cells isolated from human prostate cancers. It also closed the growth of human prostate cancer cells grafter into mice and after six weeks of treatment, it decreased tumor volume growth rate by half, and when it was stopped, tumor growth rate continued at its previous rate.  These results are interpreted as indicating a stopping of cell division instead of killing the cancerous cells.