Posts Tagged ‘mutations’

New Therapeutic Target for Lung Cancer.

Wednesday, August 3rd, 2016

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A new study published in Cell Reports found a new way to target lung cancer through the KRAS gene that is one of the most commonly mutated genes in human cancer and one that has been difficult to target. The KRAS gene (Kirsten Rat Sarcoma Viral Oncogene Homology) produces proteins called K-RAS that influence when cells divide, and mutation in K-RAS may result in normal cells dividing uncontrollably and turning cancerous. Genetic mutations of KRAS occurs in about 30 percent of lung cancer and are associated with aggressive, therapy resistant disease with a poor prognosis. “There is a dearth of treatment options for tumors initiated by this gene.” Researchers found that activity resulting from the ACSL3 gene is essential for the KRAS lung cancer cells to survive, and suppressing ACSL3 causes these lung cancer cells to die.

In their research they found that the enzymatic activity of ACSL3 is needed for the mutant KRAS gene to promote the formation of lung cancer and in addition fatty acids, that are substances of ACSL3 enzyme, have a critical role. Several complementary approaches including cell lines, mice, and tumor samples from humans were used to understand the role of the biological significance of ACSL3 in lung cancer in this study.