Posts Tagged ‘NFKB’

Breast Inflammation Related to Cancer Growth

Friday, December 24th, 2010


A study reported in the December 15 issue of Cancer Research concluded that an inflammatory process in the breast promotes the growth of stem cells responsible for the development of tumors. They further stated that “inactivating the NFKB inflammatory pathway in the breast epithelium blocks the onset and progression of the breast cancer in living animals.” Although there are side effects to suppressing the whole body’s inflammatory processes, the study showed a rationale for selectively targeting the breast only in anti-inflammatory therapy.

After 12 years of research the researchers created a mouse in which the inflammatory system in the adults breast could be regulated. These mice were programmed to develop cancer but if they selectively blocked inflammation in the breast, the tumors would not develop. They also found that this inactivation reduced the number of cancer stem cells in the breast.