Posts Tagged ‘NSAIDs’

Can NSAIDs Lower Breast Cancer Recurrence in Overweight, Obese Women

Wednesday, August 20th, 2014

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A new study published in Cancer Research concluded that the recurrence of hormone related breast cancer was cut in half in overweight and obese women who regularly used aspirin or other non steroidal anti-inflammatory drugs (NSAID’s). authors said “Our study suggests that limiting inflammatory signaling may be effective, less toxic approach to altering the cancer promiting effects of obesity and improving patient response to hormonal therapy.”  In their study researchers fround that women  whose body mass index was greater than 30 and had estrogen receptor alpha (ERa) -positive breast cancer had a 52 percent lower rate of occurrence and a 28-month delay in time of recurrence if they were taking aspirin or other NSAID’s. Using blood from obese patients, researchers carried out laboratory experiments to recreate atumor environment containing cancer cells, fat cells, and the immune cells that promote inflammation. They found that factors associated with obesity initiate a network of signaling within the tumor environment to promote growth and resistance to therapy. They concluded “These studies show that the greatest benefit from aspirin and other NSAID’s will be in those with a disease driven by inflammation , and not just obesity.”

Datwa was used from 440 women diagnosed with invasive ERa-positive breast cancer and treatedbetween 1987 and 2011. Of the group studies 48.5 percent were obese and 25,8 percent were overweight. About 81 percent took aspirin, and the rest took another NSAID.  About 42 percent and 25 percent took statins and omega-3 fatty acid respectively. After controlling for statin and omega-3 fatty acids that have anti-inflammatory effects, there was still an indication of protection from aspirin and other NSAID’s.

Can Lifestyle Factors Reduce the Risk of Esophageal Cancer?

Friday, April 12th, 2013

logo1267406_mdRecent news from the Seattle Barrett’s Esophagus Program  at the Fred Hutchinson Cancer Research Center in collaboration with Brigham & Women’s College and the University of California in San Francisco have shown that a systematic approach to early  cancer detection can boost five-year survival rates from about 15 percent to more than 80 percent. They  have also shown that modifiable lifestyle factors-from reducing obesity to quitting smoking–may also prevent progression of Barrett’s esophagus to esophageal cancer. Some of the ways to prevent this condition from progressing to esophageal cancer were identified and follow.

Earlier research in 2007 reported that people with the more aggressive form of Barrett’s may benefit gfrom preventive therapy with aspirin or other non steroidal anti-inflammatory drugs. Following Barrett’s patients over time they identified a cluster of 4 known cancer bio markers  in this group that increased their risk of developing esophageal cancer. They found that subjects with 3 or more of these bio markers who also used aspirin or other no0nsteroidal anti inflammatory drugs (NSAID’s)  had a 30 % chance of developing esophageal cancer after 10 years whereas those who did not use the aspirin had a 79% change of developing cancer with a decade. They believe aspirin and other non-steroidal inflammatory drugs may fight cancer by reducing chronic  inflammation. However, because this was a long term observational study and not a clinical trial they cannot recommend aspirin for people with Barrett’s and also advise that anyone wh uses them do so under medical direction because of the side effects such as g.i. bleeding.

Another study looked at Barrett’s and statin drugs for lowering cholesterol and found that various combinations of statin and/or NSAID’s used by patients with Barrett’s and and high grade dysplasia had a reduced risk of esophageal cancer when compared with those who did not use these drugs.

This year they lo0ked at lifestyle and esophageal cancer and found that heavy smokers with Barrett’s were more than twice as likely to develop esophageal cancer than non-smokers with Barrett’s. They also found that obesity especially belly fat, was more strongly associated with the progression of Barrett’s to esophageal cancer.

They also offered suggestions for managing the symptoms of chronic acid reflux that is a risk factor for Barrett’s. These included smoking cessation, keeping weight down, getting regular exercise, eating a diet rich in fruit and vegetables, refrain from eating four hours before retiring, elevate the head of your bed if you have heart burn, and take antacids for occasional heartburn and see you doctor if you have frequent heartburn or if over the counter medications do not help.

Painkillers May Decrease Hormone Levels That In Turn May Reduce Breast and Ovarian Cancers

Wednesday, March 31st, 2010

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Research published in the recent issue of Cancer Epidemiology, Biomarkers & Prevention concluded that postmenopausal women regularly using aspirin and other painkillers have lower estrogen levels than those not using these products and that may contribute to a decreased risk of breast or ovarian cancer.

Seven hundred forty postmenopausal women who participated in the Nurse’s Health Study were examined for an association between the use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen and concentrations of estrogens and androgens. Findings showed an inverse relationship between the frequency of painkiller use and estradiol, free estradiol, estrone sulfate and the ration of estradiol to testosterone.

Average estradiol levels were 10.5% lower among women regularly using aspirin or NSAIDs. In addition this group also showed 10.6% lower free estradiol levels, and 11.1% lower estrone sulfate levels. In addition, among regular users of any painkiller (aspirin, NSAIDs, or acetaminophen) the levels of these hormones were 15.2% lower (estradiol), 12.9% lower (free estradiol), and 12.6% lower (estrone sulfate).

Michael Thun, M.D. Vice-President Emeritus of epidemiology and surveillance research at the American Cancer Society said that the association of painkillers use and breast cancer risk is important but still unresolved. He further said that the results do not confirm a relationship between painkillers and lower circulating levels of estradiol but it is promising and further research is needed.