Posts Tagged ‘overall sirvival’

Is there a Gene Signature to Predict Malignancy and Risk of Non-Small Cell Lung Cancer?

Friday, January 13th, 2012

New Research published in a recent issue of the Journal of the National Cancer Institute concluded that the malignancy-risk gene signature was associated with overall survival (OS) and was also a prognostic and predictive indicator for early stage non-small cell lung cancer (NSCLC). . The gene signature has also been useful in predicting breast cancer risk and consists of numerous proliferative genes.
In their research, they hypothesized that the malignancy-risk gene signature would have high prognostic and predictive value for early stage NSCLC. They studied the hypothesis by using 3 different NSCLC microarray datasets ranging in number from 117 to 442. An overall malignancy risk score was generated by principal component analysis to determine the prognostic and predictive value of the signature using 2 sided statistical tests.
The malignancy-risk gene signature was statistically associated with overall survival (OS) at the .001 level for the NSCLC patients. Validation with the two additional datasets demonstrated that the malignancy-risk score had prognostic and predictive values. Of the patients not receiving chemotherapy (ACT) those with a low malignancy-risk score had increased overall survival compared with those having a high malignancy-risk score at the .007 level of probability and at the .01 level for the two independent data sets.
The researchers concluded that “the malignancy-risk gene signature was associated with OS and was a prognostic and predictive indicator.”