Posts Tagged ‘pancreatic cancer’

Dr Laszlo Boros Speaks on Deuterium Depleted Water and Cancer

Sunday, February 3rd, 2019

Buy Soma Watson Brand Online Dr. Laszlo Boros is currently a Professor of Pediatrics at UCLA and the Co-Director of the Stable Isotope Research Laboratory at the Los Angeles Biomedical Research Institute (LABIOMED) at the Harbor-UCLA Medical Center with a primary focus on studying cancer cell metabolism with the use of a specifically designed 13C-glucose tracer and mass spectroscopy. Born and educated in Hungary, Dr. Boros’ medical background includes three years of gastroenterology and pancreatology, focusing on chronic pancreatitis and pancreatic cancer. He spent two years as a visiting scholar in Essen, Germany, studying various animal models of chronic pancreatitis. In 1990, he moved to Columbus, Ohio, where he joined the history-making laboratory of Drs. Zollinger and Ellison, who described hormonal regulatory mechanisms involved in pancreatic cancer growth with a primary emphasis on diagnostics and treatment. In 1995 he became the lead investigator to clinically apply stable isotope technologies to study diabetes and cancer growth in vitro and in animal models at UCLA. He is an expert in using metabolic profiling and mitochondrial nanomechanics to further understanding of particularly aggressive cancers. Dr. Boros also participates in research projects targeting population metabolic disorders, such as diabetes and obesity, and is involved in discovering the underlying mechanisms of rare metabolic disorders arising from genetic mutations affecting vitamin transport.  Dr. Boros is an internationally proclaimed expert of metabolic water biochemistry as well as deuterium mediated kinetic isotopic effects in health and disease. Dr. Boros is the recipient of the C. Williams Hall Outstanding Publication Award from the Academy of Surgical Research of the USA (1997), the Richard E. Weitzman Memorial Research Award from the University of California (2001), the Excellence in Clinical Research Award from the General Clinical Research Center at the Harbor-UCLA Medical Center (2004), Public Health Impact Investigator Award of the United States Food and Drug Administration (2011) and received a Best Publication Award from the Metabolomics Society and Springer Nature publisher (2014). Dr. Boros serves as Chief Scientist at the Center for Deuterium Depletion, the world’s first organization to use deuterium and tracer technologies in a research clinic setting to describe and follow the health status of patients with metabolic disorders such as cancer, diabetes, and autoimmune disorders. Full CV of Dr. Boros can be viewed at

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Dr Linda Isaacs Continues the Cancer Treatments She Used with Dr Nicholas Gonzalez.

Sunday, August 26th, 2018

Dr Linda Isaacs Linda L. Isaacs, M.D., received her Bachelor of Science degree from the University of Kentucky, graduating with High Distinction with a major in biochemistry. She was elected to Phi Beta Kappa. She subsequently received her medical degree from Vanderbilt University School of Medicine in 1985. She completed a residency in Internal Medicine at the Department of Veteran’s Affairs Medical Center at New York University Medical School. She is certified by the American Board of Internal Medicine, most recently completing recertification in 2011. Dr. Isaacs worked with her colleague Nicholas J. Gonzalez, M.D., for more than twenty years, using a nutritional approach for treating patients diagnosed with cancer and other serious degenerative illnesses. After his untimely death in July 2015, she has continued with the work they shared. The treatment involves diet, which varies from patient to patient and can range from almost exclusively vegetarian to one that is heavy in animal protein and fat; individualized nutritional supplement protocols, which include large doses of pancreatic enzymes; and procedures such as coffee enemas that help the body rid itself of metabolic wastes.

Buy Xanax Next Day Delivery In 1999, Dr. Isaacs and Dr. Gonzalez completed a research study in patients diagnosed with pancreatic cancer: the results were published in the peer-reviewed journal Nutrition and Cancer, showing survival well beyond what is described in the medical literature. They also published a series of case reports in the peer-reviewed journal Alternative Therapies in Health and Medicine, and co-authored the book The Trophoblast and the Origins of Cancer. Dr. Isaacs wrote the article “Deciding to Pursue an Alternative Cancer Therapy” to help prospective patients sort through their options; it is available on her website at

Visit her website at to learn more about her treatment and review the application process to become a patient.

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Cannabis Extract Expert, Mara Gordon, Speaks on the Holistic Health Show

Sunday, July 16th, 2017

Mara Gordon, founder, Chief Process Engineer, specializes in the development of cannabis extract treatment protocols for seriously ill patients in California. She is the co-founder of Aunt Zelda’s, Calla Spring Wellness, and Zelda Therapeutics.

Prior to Aunt Zelda’s, Mara worked as a process engineer, helping Fortune 500 companies create intelligent software by utilizing the Rational Unified Process. This experience has enabled her to take a detailed and scientific approach to medical cannabis.

Recognizing a need for patient-focused software, Gordon created CDRMed, an EMR specially developed for the healthcare community. With CDRMed, physicians and medical health professionals are able to make treatment recommendations based on the latest and highest-quality data. This takes the guesswork out of selecting the correct medicines at the dispensary.

Gordon sits on the boards of Zelda Therapeutics, Daya Foundation, International Cannabis Standards Board (ICSB), and Hmbldt. She has presented at multiple CME-accredited medical conferences, including Patients Out of Time 2014, and at POT 2016, delivered a 3.5 hour course along with Drs Cristina Sanchez, Manuel Guzman, and Joe D. Goldstrich. Gordon has spoken at medical cannabis conferences in Australia, Costa Rica, Chile, Colombia, the Czech Republic, Israel, as well as numerous events throughout the USA and worldwide. These include CannMed held at Harvard Medical School in April 2016, and Medical Marijuana for Professionals 2014 and 2016. Her work is featured in the upcoming documentaries, “Weed the People”, “Mary Janes: Women of Weed”, and in Joe Dolce’s book, “Brave New Weed”.More information at:  

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Research Says Reduce-Not Increase Antioxidants to Kill Pancreatic Cancer Cells.

Wednesday, August 10th, 2016

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Conventional wisdom in popular culture is to raise antioxidants in the body to facilitate recovery from cancer researchers have found that in pancreatic cancer the last thing one wants to do is raise antioxidants levels. Instead lowering antioxidants in pancreatic cancer cells can kill them them according to the researchers of the study published in  the journal Cell.  Pancreatic cancer is a lethal disease in which 5 per cent of the cases survive 5 years. /

In normal cells oxidizing and antioxidizing agents are created in every cell and kept in a precise balance. However, in proliferating cancer cells  more oxidizing cells are being made in malignant cells but more antioxidants are being made also that counter the impact of rising oxidation and without commensurately more antioxidants the  malignant cells will die due to excessive oxidation and that is what is desired. Researchers tested  whether by increasing the level of oxidation in cancer cells,the pre-cancerous cells and malignant cells would die. When cells detect excessive oxidation, they commit suicide, following a built in program called apoptosis and one way to increase oxidation in cancer cells is to decrease levels of antioxidants in those same cells.

Researchers were interested in how best to do this without harming normal cells. The focused on a protein called NRF2 which is considered a master regulator of redox homeostasis or by which they can turn the switch to tweak and disturb the exquisite balance between oxidation and reduction in cancer cells. When NRF2 is active, cells synthesize a chemical called glutathione that is an important antioxidant. Thus, by reducing NRF2 activity or knock it out of action would seem desirable but this is not possible for two reasons. First, it is a transcription factor—a protein that regulates the activities of other genes.  Transcription factors is famously difficult to target but researchers say that would not be desirable because in addition to promoting  production of glutathione, NFR2 has a role in regulating several hundred different gene that impact on many other processes.

After conducting experiments and testing pancreatic cells in animal models they arrived at a different strategy. They used a panel of pancreatic organoids,  spherical agglomerations of pancreatic cells, sampled from people with pancreatic cancer and from healthy pancreas and were able to observe what happens when NRF2 is completely eliminated. They ran the test on normal, premalignant and malignant pancreatic organoids. They saw that the premalignant organoids carried cellular mutations in the Kras gene that is aberrant in almost all human pancreatic cancers. The malignant organoidshad that mutation and also a mutation that inactivates the powerful tumor supressor gene P53 and these with Kras are seen in most human malignancies.

Researchers, thus, saw that when NRF2 is missing the mechanism in cells that translate messages from genes to proteins (protein synthesis) is very sensitive to fluctuations in the balance between oxidants and anti-oxidants. However, protein synthesis was not impacted in normal pancreatic cells. Researchers said “We were very excited when we saw this. This meant that if we could find a way of reducing antioxidants, protein synthesis would only be impacted in precancerous and malignant cells, a potentially powerful therapeutic strategy.”

Using a mouse model they found that using two drugs–one that inhibited the beginning of the translation process that leads to protein synthesis and the other inhibited the synthesis of glutathione which is an antioxidant- was more effective in killing cancer cells that either alone and normal pancreatic cells were not affected. Further research to look at combinations and to increase efficacy are planned.

Tara & Steve Mann (Cancer Crackdown) and Bernice Yoder (Pancreatic Cancer Survivor) Interview.

Sunday, March 13th, 2016

taramannMy first guests, Tara and Steve Mann, are Co-Founders, CEO and President of Cancer Crackdown. (This is a continuation of an interview started last show). Cancer Crackdown is a 501(c)(3) Non-Profit organization, their passion is to help fighters take their battle with cancer to the next level. They are unique in that they fight alongside those battling this disease. They develop plans and help fighters and survivors to be successful in following them to reach their overall health goals. They offer a wide range of resources and encouragement for those fighting, those surviving and those that wish to prevent this disease. We all have a choice in this battle against cancer, to survive or to prevent!!
Their mission is to be the trusted source of knowledge regarding natural therapies to defeat cancer and remain cancer free. We partner with fighters and survivors by supporting and navigating them through their battle. Together, they develop a unique plan that is specific to each individual and instills in them a fearless approach to winning the battle.
Cancer Crackdown started as a small group on Facebook in January 2012 with a few people who wanted to share some information on tips and best practices during chemo. Cancer Crackdown has grown and we are now serving cancer fighters all over the world!!
Cancer fighters that can no longer take chemo or choose not to are in dire need of accurate information and guidance. Due to the vast amount of information available and many untrustworthy sources on the internet, it makes it difficult for us to make decisions about what is viable information and thus dissuades many from knowing what is worth trying. We have and will continue to research topics of interest and ensure credibility of sources. We help put patients in contact with proper practitioners in their area and locate services for them that may benefit their treatment. We are in the process of building on the services we are able to provide to cancer patients that we are so fortunate to partner with during their difficult time. More information available at:

berenice yoderMy second guest is Bernice Yoder, a 9 year pancreatic cancer survivor. Berenice says: I will be a nine year pancreatic cancer survivor this coming November. When I found out I had cancer, I had no idea what pancreatic cancer was. It had never touched my immediate or extended family. It was something you heard of or read about, not something that happened to you.

This illness changed my life. It gave me more will to live, to be able to finish raising my then 13-year-old daughter who had just lost her dad 15 months before. It taught me to fight, and to never give up. There is always hope even through the pain and grief and anger that is part of this terrible illness. I am proud to say I am a survivor of one of the deadliest cancers

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New Treatment for Pancreatic Cancer Combines Virotherapy and Immunotherapy

Wednesday, December 31st, 2014


Recent research reported by Science Digest concluded that a new treatment for pancreatic cancer that combines two different approaches-virotherapy and immunotherapy-is showing great promise. Researchers studied whether treatment for pancreatic cancer would be improved by combining the Vaccinia oncolytic virus, a virus selectively modified to infect and kill cancer cells, with a gene that modifies the bodies immune system,  Although lab studies showed that both killed cancer cells and provide immunity against cancer regrowth , the viruses have not performed well in clinical trials because the immune system attacks the virus before it can be effective.

After six weeks 87.5 percent of all mice treated with the combined treatment were clear of all tumors compared with 42.8 percent of those treated with Vaccinia virus alone. In addition, the survival rate of the mice almost doubled from 69.7 days to 138.5 days.

Four weeks after being clear of primary tumors, pancreatic cancer cells were reintroduced into the mice but no further doses of virus were give. Although cancer cells again grew in both groups of mice, after 32 days all except one mouse were again  clear of cancer. REsearch is ongoing.

Can a Chinese Herb Help Kill Pancreatic Cancer Cells?

Friday, August 29th, 2014


A new study announced in an American Physiological Society Press Release concluded that a Chinese herbal extract, triptolide, used on pancreatic cancer cells decreased GRP78 protein in the cells. thereby reducing cancer cell survival and facilitating cancer death. It is believed that GRP78 protects cells from dying ,  is more abundant in cancer cells, and helps them survive and thrive. Triptolide, an extract of  Chinese herb Tirpterygium wilforif, suppresses GRP27 leading to pancreatic cancer cell death. Authors said “Our study shows that although increase expression of GRP78 confers survival advantages in the tumor cells, prolonged exposure to tripolide induces chronic ER stress, which eventually leads to cell death.  In this context, inhibition of GRP27 by activation of the ER stress pathway by triptolide offers a novel mechanism for inhiviting the growth and survival of pancreatic cancer cells.”

Can Lifestyle Changes Prevent Pancreatic Cancer?

Friday, July 11th, 2014

logo1267406_md report that nearly 40% of pancreatic cancers could be avoided in the UK through maintaining a healthy weight and not smoking because some pancreatic cancer are related to these factors. Survival for the disease is low and there are few treatment options according to the authors. “At the same time it’s important to remember that people can take steps to reduce their risk of developing pancreatic and other cancers, by not smoking and by keeping a healthy weight especially if you are prone to too much around your middle. ” The organization plans to more than double the funding for this disease to affect the outcome. More information is available at:                                              

Can a Chinese Herbal Extract Kill Pancreatic Cancer Cells?

Wednesday, July 9th, 2014


A new study reported in Daily Digest News and published in the American Journal of Physiology-Gastrointestinal and Liver Physiology concluded that pancreatic cancer cells may be killed by a chinese herbal extract.  A protein known as GPR78 is abundant in cancer cells, compared to normal cells, and is responsible for prevention cells from being destroyed. It is believed this protein helps the pancreatic cancer cells survive despite treatment.  Using a Chinese extract from the herb Tirpterygium wilforti, known as triptolide,  researchers found it potentially suppresses GRP78, and inevitably cause the death of pancreatic cancer cells.  Researchers discovered that the “unfolding protein response (UPR)” that helps boost the cell’s protein-folding ability that allows it to function properly-worked well in triptolide=treated cells, leading to cell death in malfunctioning cells. Researchers further said “Our study shows that although increased expression of GRP78 confers a survival advantage to the tumor cells, prolonged exposurte to triptolide induces chronic ER stress, that eventually leads to cell death. In this context, inhibition of GRP78 by activation of the ER stress pathway  by triptolide offers a novel mechanism for inhibiting the growth and survival of pancreatic cancer cells.”

Is there a Non-Invasive Procedure to Diagnose Pancreatic Cancer?

Wednesday, May 28th, 2014

logo1267406_mdNew research presented recently at the American Society for Microbiology”s  annual meeting concluded that patients with pancreatic cancer have a different and distinct profile of specific bacteria int their saliva compared to healthy controls and  patients with other cancers or pancreatic disease. The researchers believe that the ratio of particular types of bacteria in the saliva may indicate pancreatic cancer. In their study, the researchers compared the diversity of saliva bacteria of 131 patients (63 females, 68 males) being treated in California. Of those, 14 had been diagnosed with pancreatic cancer, 13 with pancreatic disease, 22 with other forms of cancer, and 10 who were disease free. Results showed that those with pancreatic cancer had higher levels of two oral bacteria-Leptotrichia and Campylobacter when compared to the healthy or those with diseases including pancreatic disease. Those with pancreatic cancer also had lower levels of Streptococcus. Treponema, and Veillonelia. Researchers concluded “Our results suggest the presence of a consistently distinct microbial profile for pancreatic cancer.”