Posts Tagged ‘postmenopausal women’

Does a Low Fat Diet Effect Cancer Death?

Wednesday, April 20th, 2016

A new study presented at the American Association for Cancer Research annual meeting concluded that women who stay on a low fat diet for about eight years  reduce their risk of death from invasive breast cancer and improve their survival rate when compared with women who had not stayed on a low fat diet. Researchers followed 48,835 postmenopausal women between the ages of 50 and 79 with no previous breast cancer. In this randomized clinical trial the women had also had normal mammograms and normal dietary fat intake.  Of this group, 19,541 women were placed on a low fat diet with nutritionist-led group sessions attempting to reduce fat intake  to 20% of energy and increase consumption of fruit, vegetables, and grain. The other 29,294 women followed their usual dietary pattern.

Following about eight years on the low fat diet, 1,767 women were diagnosed with breast cancer. Overall survival from diagnoses of breast cancer was higher in the study group: 82% vs 78%. They believed the reduction was partly due to better survival following the breast cancer diagnosis. Researchers said “This was the first time we had examined the death after breast cancer among this group, and we found that a sustained low fat diet increased the survival rates among postmenopausal women after a breast cancer diagnosis.” They continued “The study also suggests that women would need to remain on the low fat diets to maintain the benefits of the dietary intervention.”

Researchers also found that most breast cancer characteristics such as size, nodal status, and distribution of poor prognosis, triple negative cancers and HER2 positive cancers were similar in the two groups of women. However,m there were fewer progesterone receptor negative cancers in the study group (28.4% vs 33%) and they also  found a lower cardiovascular disease mortality in the study group.

Does Obesity Increase the Risk of Breast Cancer among Post Menopausal Women?

Wednesday, June 17th, 2015

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A recent analysis in an article in  online  JAMA Oncology suggested that postmenopausal women who were overweight and obese had an increased risk of invasive breast cancer compared to women of normal weight. Results were based upon data from 67,142 postmenopausal women between 1993 and 1998 with a median age of 13 years of follow-up. There were 3,388 invasive breast cancers.

Results showed 1) women who were overweight or obese as measured by the body mass index had an increased risk of invasive breast cancer compared to women of normal weight measured by the body mass index; 2) the risk was greatest for women with a body mass index (BMI) greater than 35 who had a increased risk of 58 percent when compared with women of normal weight (BMI under 25); 3) a BMI of 35 or higher was associated with an increased risk of estrogen and progesteron receptor-positive breast cancer but not estrogen receptor-negative cancers; 4) obesity was associated with markers of poor prognosis: women with a BMI greater than 35 were more likely to have large tumors, evidence of lymph none involvement and poorly  differentiated tumors; 5) women with a baseline BMI under 25 gaining more than 5 percent body weight during the follow-up period had an increased risk of breast cancer; 6) among overweight or obese women who changed weight (gain or lose) there was no increased risk of breast cancer during follow up; and 7)post-menopausal hormone therapy had no effect on the BMI-breast cancer relationship.  Researchers further said “Obesity is associated with a dose-response increased postmenopausal breast cancer risk, particularly for estrogen receptor-and progesterone receptor-positive disease, but risk does not vary by hormone therapy use ot race/ethnicity.” More research is needed according to the researchers.

Does Postmenopausal Breast Cancer Risk Decrease with Physical Activity?

Friday, August 22nd, 2014

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A new study published in Cancer Epidemiology, Biomarkers & Prevention concluded that post menopausal women who undertook regular physical activity over the past 4 years that was equivalent to 4 hours of walking per week (cycling or other sports for 2 hours/week)  had a 10 percent lower risk for invasive breast cancer compared with women who exercised less during those four years.

Data was analyzed from over 59,300 post menopausal women in France. The me4an duration of follow up was 8.5 years during which time 2,155 women were diagnosed with a first primary invasive brteast cancer. The total amount of self-reported physaical activity per week was calculated and the reduction in invasive breast cancer among those having a higher amount of physical activity was independent of the body mass index, weight gain, waist circumference,  and the level of activity from 5 to 9 years earlier.