Posts Tagged ‘recurrence’

Can Smoking Interfere with Breast Cancer Treatment?

Friday, June 24th, 2016

 

Logos 005New research published in the British Journal of Cancer  concluded that common treatment for breast cancer works less well in patients who smoke, compared to non-smokers. The study followed 1,016 breast cancer patients in southern Sweden diagnosed between 2002 and 2012. At the time of surgery they were asked whether they were smokers or non-smokers and about one in five said they were a regular smoker or social smoker. The impact of smoking was evaluated based upon type of breast cancer treatment received after surgery.

Results showed that women over age 50 treated with aromatase inhibitors, were affected by smoking. The aromatase treatment prevents the body from generating estrogen in fatty tissue and thereby reduces the risk of recurrence in women with estrogen-receptive positive breast cancer. This treatment worked significantly better in non-smokers. Researchers said “Smokers who were treated with aromatase inhibitors had a three times higher risk of recurrence of breast cancer compared with the non-smokers who got the same treatment.” They also found that “the smokers also had an increased risk of dying, either from the breast cancer or from other illnesses, during the time we followed them.”

However, the researchers found little or no difference between smokers and non-smokers treated with the drug tamoxifen, radiotherapy, or chemotherapy. Despite telling patients of the importance of stopping smoking only ten perce of the 206 smokers stopped in the first year after surgery. Researchers said the number of smokers who stopper was too small to determine if that made a difference in their future risk. More research is needed.

Can High Risk Breast Cancer Recurrence Patients be Identified?

Friday, September 25th, 2015

logo1267406_md

A new study published in the journal Clinical Epigenetics concluded that a new simple blood test might be able to determine the risk of recurrence, or the cancer invading other organs such as the lungs, bone or brain for women successfully treated for breast cancer. Researchers identified 21 DNA hypermethylation hotspots–gene locations along the 3 billion chemical bases of DNA–with increased levels of methylation that could indicate the existence of metastatic cancer.  They said “These findings could lead to a highly sensitive blood-based test panel–a type of liquid biopsy–which could help improve the care of women with breast cancer.” They said further “This 21-gene signature is a potential biomarker that could indicate patients who are at high risk of cancer recurrence, either in the breast or elsewhere in the body, and who might benefit from additional therapy to eliminate the potential of recurrence.” In this study the 21 genes that were differentially methylated were consistently higher in patients with metastatic breast cancer when compared with levels in healthy individuals and cancer free survivors.

 

Can Coffee Help Prevent Recurrence of Breast Cancer?

Wednesday, May 1st, 2013

logo1267406_mdMail Online reports on research at Lund University in Sweden that concluded that drinking  coffee could decrease the risk of breast cancer recurring in women taking  the widely used drug Tamoxifen. Patients who took the pill along with two or more cups of coffee daily, reported less than half the rate of cancer recurrence, compared to those taking Tamoxifen with one or less cups of coffee daily. -Six hundred breast cancer patients in southern Sweden were followed for an average of 5 years. Approximately 300 took  Tamoxifen that reduces the risk of new tumors by blocking  estrogen receptors. However, it is unknown how the coffee interacts with treatment to reduce recurrence. One theory is that the coffee activates the Tamoxifen to make it more effective. More research is needed to confirm this observational study.

Can Carbohydrates Increase the Risk of Cancer Recurrence Among Colon Cancer Survivors?

Friday, November 16th, 2012

A new study published in the Journal of the National Cancer Institute concluded that colon cancer survivors whose diet is high in complex sugars and carbohydrate-rich foods are far more likely to have a recurrence of the disease than those patients who eat a more balanced diet.

One thousand eleven stage III colon cancer patients who had undergone surgery and follow up chemotherapy for their disease  reported their dietary intake during and six months after the trial.  Researchers tracked the total carbohydrates and glycemic index (a measure of how quickly the blood sugar levels rise after eating particular food), and glycemic load (a measure of the amount of carbohydrate actually consumed) on subjects and looked for a relationship between these measures and recurrence of cancer.

Subjects with the highest dietary levels of glycemic load and carbohydrate intake were found to have an 80 percent increased risk for colon cancer recurrence when compared to those who had the lowest levels. In addition, among subjects who were overweight or obese (a body mass index above 25 kg/m2, the increase was even higher. Researchers say “In light of our and other’s research, we theorize that factors including a high glycemic load may stimulate the body’s production of of insulin. That, in turn, may increase the proliferation of cells and prevent the naturalk cell-death process in cancer cells that have metastasized from their original site.” The researcher concluded “Our study certainly supports the idea that diet can impact the progression of colon cancer, and that patients and their doctors should consider this when making post-treatment plans. But further research is nee4ded to confirm our findings.”

Interviews on Fibromyalgia and Angels Now Available

Sunday, September 16th, 2012

Dr Susan Kolb (left) and Dr Carolyn Porter (right) were interviewed on the Holistic health Show on Saturday. Dr Kolb  is founder of Plastiko Surgery Center, the Millennium HealthCare  and Avatar Cancer Center, hosts Temple of health on BBS Radio and is author of The Naked Truth About Breast Implants. More information is available earlier on this site and on http://www.plastikos.com

Dr Carolyn Porter channels angels and is author of The Realness of a Woman, Healing with Color, The Faith of Empowerment, and Adrenal Fatigue.  More information was presented earlier on this site and can be found at: http://www.where miracleshappen.com

Enjoy the Interview below:

Recurrence of Most common Type of Breast Cancer More Likely Among Obese or Overweight Women.

Wednesday, September 5th, 2012

Recent research published in Cancer, a peer reviewed journal of the American Cancer Society, concluded that overweight as well as obese  women have a higher risk of recurrence of the most common type of breast cancer despite optimal cancer treatment.  Based upon results the  researchers believe the extra body fat causes hormonal changes and inflammation that may cause some cases of breast cancer to spread and recur despite treatment.

The study compared the health outcome of obese and overweight women with others of normal weight in a large sample of women with stage  I to III breast cancer who had participated in the National Cancer Institute sponsored treatment trials. All participants had normal heart, kidney, liver, and bone marrow function and this excluded patients with other significant health issues. Researchers found that an increased body mass index significantly increased a woman’s risk of cancer recurrence and death despite optimal treatment.  They found a step wise relationship between increased body mass index and poor outcomes in women with hormone receptor -positive breast cancer which is the most common type of breast cancer accounting for about 2/3 of all breast cancer cases in the United States and world. The researchers said “We have found that obesity at diagnosis of breast cancer is associated with about a 30 percent higher risk of recurrence and a nearly 60 percent higher risk of death.”

More Sensitive Blood Test Identifies Recurring Breast Cancer Earlier.

Wednesday, April 4th, 2012

Research presented at the 243rd National Meeting & Exposition of the American Chemical Society (ACS) on March 29 concluded that a new more sensitive blood test is twice as effective at detecting breast cancer a year earlier than current blood tests. The researchers said the recurrence of breast cancers for women within 10 years of treatment is about 1 in 5 and early detection of these can save lives. However, current tests are not very sensitive  and the best test known as the CA 27 29, misses many cases of recurring cancerr and detects them late.

The researcher said “We have identified a group of nine biomarkers that signal recurrence of breast cancer.”  “Our markers detect twice as many recurrences as the CA marker does at the same specificity. They also detect cancer recurrence earlier, about 11-12 months sooner than existing tests. They accomplish this with blood samples, rather than biopsies. with less discomfort to patients.”

To locate these markers the researchers analyzed many hundreds of “metabolites” in the blood of breast cancer survivors. The markers can be detected with a mass spectrometer in clinical labs and compared with CA values to generate a score that indicates whether or not the cancer has probably returned. If believed to have returned the patient would likely undergo imaging tests to locate the tumor. It is hoped that the new test will be available within a year.

Can Starch Intake Affect Breast Cancer Recurrence Risk?

Friday, January 6th, 2012

Research presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium concluded that there is a link between starch intake and a greater risk of breast cancer recurrence. It is not just overall carbohydrate but starch intake and “women who increased their starch intake over one year were at a much likelier risk for recurring.”
Researchers analyzed a subset of 2,651 women who participated in the Women’s Healthy Eating and Living (WHEL) Dietary Intervention Trial that enrolled 3,088 breast cancer survivors in a plant-based intervention trial. Subjects were followed for 7 years.
Researchers looked at how changes in carbohydrate intake influenced breast cancer recurrence in the subset of subjects. Carbohydrate intake data was obtained from multiple 24-hour dietary recalls at baseline and at one year later. In an annual telephone interview subjects reported what they had eaten during the past 24 hours. Carbohydrate intake at baseline was 233 grams daily. Women whose cancer recurred had a mean increase in carbohydrate intake of 2.3 grams a day during the first year whereas women whose cancer did not recur had a mean increase of 2.7 grams per day during the same period. Changes in starch intake were evaluated and the mean change for women who had recurrences was -4.1 grams a day and for those whose cancer did not return it was -8.7 grams a day. Overall, changes in starch accounted for 48% of the changes in carbohydrate intake. In addition, when changes in the starch intake were grouped into quartiles of change, the risk of recurrence was 9.1% among women who decreased their starch intake the most for the year compared to a risk of 14,2% for women who increased their starch intake the most over the year. After stratifying the sample by tumor grade, the researchers found that the increases observed were limited to women with lower-grade breast cancer.