Posts Tagged ‘research’

Irregular Sleep Patterns associated with several Metabolic Disorders

Wednesday, June 19th, 2019

A new study in Diabetic Care reported that not following a regular bedtime and wake up schedule and getting different amounts of sleep each night can put people at higher risks for obesity, high cholesterol, hypertension, high blood sugar, and other metabolic disorders. In fact, they found that for every hour of variation in bed time and time asleep, a person can have up to a 27% greater chance of experiencing a metabolic abnormality. Past studies have shown a link between insufficient sleep and metabilic disorders but had not evaluated the factor of irregular sleep and disorders. This research showed that even after considering the amount of sleep a person gets and other lifestyle factors, everyt one hour night to night difference in bed time or the duration of a nights sleep multiplies the adverse metabolic effect.

In this study researchers followed 2003 men and women, ages 45 to 84, participating in the NHLBl-funded Multi-Ethnic Srtudy of Atherosclerosis. Subjects were followed for a median of 6 years to evaluate the relatiopnship between sleep regularity and metabolivc effects. Subjects wore actigraph wrist ewatches to closely tract sleep schedules and to provide objectivity for seven consecutive days.  They also kept a sleep  diary and responded to standard questionaires about sleep habits and other lifestyle and health factors. The actigraphic tracking took place between 2010 and 2013 and subjects were followed to 2016-2017. Results showed the variations in sleep duration and bedtimes preceded the development of metaboliv disorders and provides some evidence supporting a causal link between iurregular sleep and metabolic disfunction.  Other findings include that participants whose sleep varied more than one hour were more likely to be African-American, work non-day shift schedules, smoked, and had shorter sleep duration.  This group also had higher rates of depression symptoms, total caloric intake, and index of sleep apnea.  Researchers said that increasing sleep duration or bedtime variation was strongly associated with multiple metabolic and simultaneous problems such as lower HDL cholesterol. and higher waist circumference, blood pressure,  total triglycerides, and fasting glucose. In summary, maintaining as regular sleep schedule has beneficial metabolic effects.

New Early Blood Test for Lung Cancer detection.

Wednesday, June 5th, 2019

Holistic-Health-Show-with-Dr-Carl-O-Helvie

The Arizona Daily Star reported a study on a new blood test to identify to detect and quantify early cancer cells carried out at the University of Arizona. Researchers combined the latest in epigenetics that reports genes that turn on and off with informatics that includes advanced data-processing and analytics. Researchers said they could successfully detect early stage lung cancer that iws commercialized in a new company, DesertDx LLC.

The test is based on a process called methylation by which cancer disrupts the DNA makeup. It recognizes biological markers for methylation to detect and quantify the presence of cancer cells.  These markers allow doctors to evaluate the effectiveness of surgery by comparing the markers before and after surgery.  It also allows clinicians to assess for recurrence of cancer.  One authority said it is best used in conjunction with computerized tomography, of CT scans.  He continues on to say “You might see a nodule in a CT scan image, but up until now we haven’t had an easy way to know if what we see is cancerous or benign. The only way is a tissue biopsy.”  “This blood test allows us to characterize what we’re able to see in a scan and say whether it’s cancer or not, all using a routine blood draw.”

Researchers report Antibiotics in World Rivers Exceed Safe Limits up to 300 times.

Wednesday, May 29th, 2019

 

Holistic-Health-Show-with-Dr-Carl-O-Helvie

In a study presented at the annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC) in Helsinki on May 27 and 28 researchers reported on levels of antibiotics in the worlds rivers which was a first for this type of study. They compared the assessed levels in rivers with established safe levels  by the AMR Industry Alliance , which depending upon the antibiotic may range from 20 to 32,000ng/l.

Researchers reported that concentrations of antibiotics found in some of the world’s rivers exceed safe’ levels by up to 300 times. They assessed for 14 commonly used antibiotics in rivers in 72 countries in six continents and found antibiotics at 65% of the sites monitored. The most prevalent antibiotic was trimethoprim, used to treat urinary track infections, which was found at 307 of the 711 sites.   In the River Thames and one of its tributaries in London, the researchers found a total antibiotic concentration of 233 nanograms per litre (ng/l), whereas in Bangladesh the concentration was 170 times higher. Ciproflaxacin, used to treat bacterial infections, most frequently exceeded safe levels, surpassing the safety levels in 51 places. Metronidazole, also used to treat bacterial infections including skin and mouth infections, exceeded safe levels by the biggest margin, with concentrations at one site in Bangladesh 300 times greater than the ‘safe’ level.

The ‘safe’ limits were most frequently exceeded in Asia and Africa, but sites in Europe, North America and South America also had elevated levels showing that antibiotic contamination is a “global problem.” Sites where antibiotics exceeded ‘safe’ levels by the greatest degree were in Bangladesh, Kenya, Ghana, Pakistan and Nigeria.  A site in Austria was ranked the highest of the European sites monitored. Researchers found that high-risk sites were often near wastewater treatment systems, waste or sewage dumps and in some areas of political turmoil

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Longevity/Fasting/Stem Cells and Dr Valter Longo, the Guru of Longevity

Sunday, July 15th, 2018

Professor Valter Longo is internationally recognized as a leader in the field of ageing studies and related diseases. His discoveries include some of the major genetic pathways that regulate aging and life-threatening diseases and the identification of a genetic mutation that protects men from several common diseases.

He is a Professor of Gerontology and Biological Science and Director of the Longevity Institution at the School of Gerontology at the University of Southern California in Los Angeles, one of the leading centers devoted to teaching and research on ageing. He is also director of the Oncology Laboratory and longevity at the Institute of Molecular Oncology IFOM in Milan.

Professor Longo received the Nathan Shock Lecture Award from the National Institute on Ageing (NIA/NIH) in 2010 and in 2013 the Vincent Cristofalo ‘Rising Star’ Award for Research on Ageing, and the 2016 Glenn Award for research in the Biology of Aging.

In 2015, after a number of his papers were among the most widely cited in the biomedical field, Time magazine called him a ‘guru of longevity’.

Doctor Longo received a PhD from North Texas in 1992, and another one from UCLA in 1997 and completed post doctoral training in 2000. He has carried out research in the areas of fasting and longevity, cell biology and genetics, the regulation of aging and multiple  stress resistance systems in yeast and mammals, cancer, diabetes and Alzheimer’s.  He has over 70 peer reviewed articles, 4 books/chapters, multiple research grants, active grant reviewer, and student research advisor. He is author of the best seller The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight

More information is available at:                                                                              http://gero.usc.edu/cv2013/CV-LongoV2013.pdf

www.CreateCures.org

Enjoy the Interview Below:

 

Childhood Cancer Survivors at Increased Risk of Adult Heart Problems

Wednesday, March 28th, 2018

A new study published in the European Heart Journal concluded that survivors of childhood cancer are at increased risk of suffering prematurely from cardiovascular disease in adulthood.

In the study survivors of childhood cancer were followed into adulthood and compared with a non cancer sample from the general population,. The study population as adults were at higher risk of high blood pressure and dyslipidaemia (unusually high levels of cholesterol and other fats in the blood)  These conditions appeared 6 and 8 years earlier than in the general population controls. In addition, the childhood survivors had a nearly two fold increase risk of cardiovascular diseases such as congestive heart failure, and venous thromboembolism. Cardiovascular  disease was found in 4.5% of survivors and occurred in the majority before the age of 40 and nearly eight years earlier than the general population control.

Between October 2013 and February, 2016, a total of 951 adult long term survivors of childhood cancer underwent a clinical exam that included assessing factors that might put them at higher risk of cardiovascular disease, such as high blood pressure, and dyslipidaemia. Their medical history such as whether or not they smoked and whether there were family members with a history of cardiovascular disease was examined. The survivors ages range from 23 to 48 at follow up and the general population control numbered 15,000. Researchers concluded “Our results show that these survivors of childhood cancer have a substantially elevated burden of prematurely occurring traditional cardiovascular risk factors and cardiovascular disease.” Many of the survivors were unaware of their cardiovascular risk prior to the study.

The most common cardiovascular risk factors identified were high blood pressure and dyslipidaemia that involved 23% and 28% respectively whereas diabetes was only found in 2%. These conditions also occurred earlier than in the general population control.  At least one cardiovascular disease was found in 4.5% of the survivors and tthe most common was that affected 2%. venous thromboembolism.  In addition, 1.2% had congestive heart failure, 0.5% had stroke or peripheral artery disease,, and 0.4% had atrial fibrillation.

Researchers said treatment of childhood cancer include chemotherapy and radiation can affect the heart causing temporary or permanent damage to heart cells and blood vessels. Further research is planned.

 

Dr William Bengston cures Cancer in Mice with Energy Healing.

Sunday, March 25th, 2018

Dr William F. Bengston is a professor of statistics and research methods, and the President of the Society for Scientific Exploration, an international group of scientists and researchers who study anomalies.  Dr. Bengston has been researching anomalous healing for over thirty five years, and has numerous publications in scientific journals.  He has also lectured widely in the U.S., Canada, and Europe.

His memoir, The Energy Cure, is published by Sounds True.  Bill’s research has produced the first successful full cures of transplanted mammary cancer and methylcholanthrene induced sarcomas in mice by energy healing techniques that he helped to develop.  He has also investigated assorted correlates to healing such as EEG and fMRI entrainment, and geomagnetic micropulsation anomalies in healing space.  His current research focuses on the attempt to record and store healing in both biological and physical systems, and to be able to reproduce the healing effect without the healer.

Enjoy the Interview below:

 

 

Some skin bacteria may protect against cancer.

Wednesday, March 7th, 2018

A new study published in Science Advances concluded that there is a potential role for some bacteria on the skin—protecting against cancer. S epidermidis. a common bacteria on healthy skin, exerts a selective ability to inhibit the growth of some cancers, They said “This unique strain of skin bacteria produces a chemical that kills several types of cancer cells but does not appear to be toxic to normal cells.” The researchers found that S epidermidis strain produces the chemical compound SN-hydroxyaminoporine (6-HAP) s  epidermidis on their skin. The mice that did not make 6-HAP had many skin tumors after being exposed to cancer-causing ultraviolet rays but mice with S epidermidis strain producing 6-HAP did not. 6-HAP is a molecule that impairs the creation of DNA , known as DNA synthesis, and prevents the spread of transformed cancer cells as well as the potential to suppress the development of ultraviolet induces skin cancers.

Mice receiving intravenous injections of 6-HAP every 48 hours over a two week period experienced no apparent side effects, but when transplanted with melanoma cells, their tumor size was suppressed by more than 50 percent compared to the control group., They said “There is increasing evidence that the skin microbiome is an important element of human health. In fact, we previously reported that some bacteria on our skin produce antimicrobial peptides that defend against pathogenic bacteria such as Staph aureus.”However, they said further study is needed to determine how 6-HAP is produced, if it can be used for prevention of cancer, or if loss of 8-FAP increases cancer risk.

Chemo-Brain is part of Cancer Progression and Chemotherapy

Friday, December 1st, 2017

Chemo brain or chemo fog are the memory and thinking problems experienced by cancer survivors are not just the result of chemotherapy but may start as the tumor forms and develops  before chemo was used according to a new study published in the journal Neuroscience.  Researchers found that female mice with a form of breast cancer demonstrat4ed impaired performance on learning and memory tests before chemotherapy drugs were used., They said “Our work isolated that the cancer is responsible for some of the memory and thinking complaints experienced by cancer survivors, and that drug therapy adds to the problem.” “Both factors independently effect brain function in different ways, which can lead to the development of other psychological disturbances, such as anxiety and depression.” Researchers said as many as 65on. taking longer to complete tasks, and difficulty multitasking.

Progression of tumor and later chemotherapy lead researchers to the identification of three different brain changes. 1)The combination of tumor growth and chemotherapy led to shrinkage of . While the tumor is developing, the body’s immune system releases cytokines  to inhibit the cancer development. Researchers found this reaction caused in the brains nervous system impairing its function. 2) Chemotherapy limited the production of new brain cells in the regions responsible for memory function which lead to a loss of memory. 3)  The combination of tumor growth and chemotherapy lead to shrinkage in brain regions that are important for learning and memory.

the study involved female mice, half with cancer and the other half without. Learning and memory tests were administered initially to determine the the impact of the tumor on the brain. After this mice were either given chemo or a saline solution (control). .Tests were again administered plus some additional ones. After testing was completed researchers brain images, tissue, and blood samples were used to analyze changes in brain structure and cytokinase activity mentioned earlier Before treatment mice with tumors performed less well on memory and learning tests than mice without tumors. After chemotherapy the performance of cancerous mice worsened, and the non-cancerous mice also showed sign’s of deterioration     Further research is planned..

 

Drinking Coffee may Increase Life Span.

Wednesday, November 29th, 2017

 

A review of over 200 studies published in the British Medical Journal suggest that frinking three or four cups of coffee daily is linked to a lower risk of early death  and getting heart disease  than not drinking coffee. The researcher said drinking coffee “is more likely to to benefit health than harm it” for a range of health outcomes such as cancer, diabetes, kiver dusease and dementia. Exceptioms are women who are pregnant and those who suffer fractures.

No firm conclusions can be drawn because the majority of studies were observational but back up other recent studies. Thus, they say “with the exception of pregnancy and women at risk of fractures “coffee drinking appears safew within usual patterns of consuymption” and could be tested further inrandomized studies.

In the study the largest reduction in death was related to drinking 3 cups a day compared with non-coffee drinkers. Drinking moire than 3 cups daily were not associatioted with harm but were not as beneficial. Beneficial effects related to a lower risk of several cancers including prostate, endometrial, skin, and liver, as well as tyoe 2 diabete, gall stones, and gout. The greatest benefit weas seen for liver disease such as cirrhosis. Additional benefits were seen for Parkinson disease, depression, and Altzheimers disease. Researchers recommended against starting drinking coffee for health benefits until the evidence of an association is stronger.

Metastatic Prostate Cancer predicted with new Biomarker in Lab. .

Wednesday, November 22nd, 2017

Many.prostate cancers that are usually diagnosed in older men are slow growing and not considered fatal.  But some become aggressive and spread beyond the prostate, making them difficult to treat and life-threatening. With current knowledge doctors are unable to determine which will be slow growing and which will spread to other sites. In this study published recently in Clinical Cancer Research  report discovering a genetic signature .within prostate cancer that can predict which tumors are likely to metastasize.

Using several data sets of prostate cancer patients and outcomes researchers found that a high number expressed two genes:  TOP2A and EZH2 were associated with early recurrence of prostate cancer and metastatic spread leading to an increased risk of death. Strong metastatic tendencies were only expressed if both genes were found in the tumor. Researchers said: “Altogether we found that high levels of TOP2A and EZH2 expression consistently associated in the progression to a metastatic and lethal disease. ”

Using mouse prostate cancer cells in the lab, researchers found that cells containing overexposed  TOP2A and EZH2  genes were highly sensitive to attack with a combination of 2 drugs. However, clinical trials are necessary to make a definitive statement. It is hoped that attacking these genes with drugs may prevent aggressive cells from p metastasizing. .