Posts Tagged ‘statins’

Can NSAIDs Lower Breast Cancer Recurrence in Overweight, Obese Women

Wednesday, August 20th, 2014


A new study published in Cancer Research concluded that the recurrence of hormone related breast cancer was cut in half in overweight and obese women who regularly used aspirin or other non steroidal anti-inflammatory drugs (NSAID’s). authors said “Our study suggests that limiting inflammatory signaling may be effective, less toxic approach to altering the cancer promiting effects of obesity and improving patient response to hormonal therapy.”  In their study researchers fround that women  whose body mass index was greater than 30 and had estrogen receptor alpha (ERa) -positive breast cancer had a 52 percent lower rate of occurrence and a 28-month delay in time of recurrence if they were taking aspirin or other NSAID’s. Using blood from obese patients, researchers carried out laboratory experiments to recreate atumor environment containing cancer cells, fat cells, and the immune cells that promote inflammation. They found that factors associated with obesity initiate a network of signaling within the tumor environment to promote growth and resistance to therapy. They concluded “These studies show that the greatest benefit from aspirin and other NSAID’s will be in those with a disease driven by inflammation , and not just obesity.”

Datwa was used from 440 women diagnosed with invasive ERa-positive breast cancer and treatedbetween 1987 and 2011. Of the group studies 48.5 percent were obese and 25,8 percent were overweight. About 81 percent took aspirin, and the rest took another NSAID.  About 42 percent and 25 percent took statins and omega-3 fatty acid respectively. After controlling for statin and omega-3 fatty acids that have anti-inflammatory effects, there was still an indication of protection from aspirin and other NSAID’s.

Can High Cholesterol Fuel the Growth and Spreqd of Breast Cancer?

Wednesday, December 4th, 2013

logo1267406_mdA new study published in the journal, Science, concluded that a by-product of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancer. Researchers also found that anti-cholesterol drugs like statins seem to reduce the effects of the estrogen-like molecule.

These early findings used a mouse model (that are highly predictive of what occurs in humans)  andtumor cells the study explained the link between high cholesterol and reast cancer, especially in post menopausal women. The research also shows that dietaqry changes and /or therapies to reduce cholestero0l may offer a simple, accessible way to reduce breast cancer risk. The researchers said -“What we have found is a molecule—not cholesterol itself, but an abundant metabolite of cholesterol–called 27HC that mimics the hormone estrogen and can independently drive the growth of breast cancer/” The hormone estrogen feeds an estimated 75% of all breast cancers and 27HC behaves similarly toestrogen in animals.

Researchers said “The worse the tumors, the more they have of the enzyme” (that makes the 27HC molecule. More studies are planned.