Posts Tagged ‘T cells’

Interview with Dr Robert Eslinger on a Comprehensive Plan for Cancer

Sunday, March 17th, 2013

drbobincoatsizedMy guest yesterday was Dr Robert Eslinger who is the Medical Director of the Reno Integrative Medical Center. More information was presented earlier on this site and can be found at

Enjoy the interview below:



Is Protein Balance Involved in Preventing Cancer?

Friday, March 15th, 2013

logo1267406_mdA new study published in a current issue of Developmental Cell concluded that two proteins previously believed to carry out the same function are actually antagonists of each other, and keeping them in balance is necessary to prevent cancer. Results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the two proteins. The proteins, Rp122 and Rp122-like1 contribute to the process of making additional cellular proteins and are created by two similar genes. This lead to researchers to believe they had similar functions. However, the current researchers said “Not only are they performing different functions, they are antagonizing each other.”

In their research Rp122 was knocked out in zebrafish and without this zebrafish do not develop a type of T cells that help fight infection. The same results were observed when they knocked out Rp122-like1 and indicating that both proteins are independently needed to enable stem cells to give rise to T cells. When researchers tried to restore T cells in zebrafish that lacked Rp122 by adding back Rp122-like-1 it did not work. The reverse was also true.  Thus, researchers concluded that although both are required to produce stem cells,l they do not perform the same function. Next researchers looked at the level of different proteins invlived in stem cell production when either Rp122 or Rp122-like-1 were absent and found that without Rp122-like1 cells had lower levels of a protein known as Smad1 that is a critical driver of stem cell development. And when Rp122 disappeared, levels of Smal1 increased dramatically. Roth proteins can bind directly to the cellular RNA from which Smal1 is produced, suggesting that they maintain balance in stem cell production via their antagonistic effects on Smal1. The researchers said ” I like to think of Rp122 as a brake, and Rp122-like1 as a gas pedal and in order to drive stem cell production both need to be employed properly.  As an example they said too much Rp122 and stem cell production shuts off, decreasing the number of blood cells and leading to problems such as anemia, whereas, too much Rp122-like1 can create an over-production of stem cells leading to leukemia.

Do You Think Exercise is Important to Prevent Recurrence of Cancer?

Wednesday, October 17th, 2012

Recent research presented at the Integrated Biology of Exercise VI meeting as   a poster presentation titled Effect of Exercise on T Cells in Cancer Survivors concluded that when cancer survivors  exercise for several weeks after they finish chemotherapy their immune systems remodel themselves to become more effective in fending off future incidences of cancer and thus significantly reduce the chances of secondary cancer.

Previous research showed that after chemotherapy the majority of T cells became senescent, with a decreased ability to fight infections and cancers.  Thus, rebuilding the responsive native T cells is critical for regaining immune function and cancer-fighting ability.

In their study -researchers took blood samples from each of the cancer volunteers to examine how many senescent and native T cells each had. The subjects were then  enrolled in a 12 week exercise program that was individualized for the study participants, incorporating elements of cardiovascular exercise, strength and endurance training, and exercises for flexibility, posture and balance with extra emphasis to areas where participants were weak.

After the 12 week program, researchers took a second blood sample and ran the same T cell analysis.  Results showed that the ratio of senescent to native T cells changed favorably in the majority of participants and most regained greater numbers of native T cells. Researchers said “What we’re suggesting is that with exercise, you might be getting rid of T cells that aren’t helpful and making room for T cells that might be helpful.”